Chromone glycosides and hepatoprotective constituents of Hypericum erectum

An, Ren Bo; Jeong, Gil Saeng; Beom, Jin-Seon; Sohn, Dong Hwan; Kim, Youn Chul

doi:10.1007/s12272-009-2008-1

Cited by 15 publications

(7 citation statements)

References 16 publications

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“…Furthermore, An et al [57] also showed that 1,3,5,6-tetrahydroxyxanthone and I3, II8-biapigenin, isolated from the methanolic extract of the whole plant of H. erectum , had moderate hepatoprotective activity against tacrine-induced cytotoxicity in HepG2 cells.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of a natural antidepressant, Hypericum perforatum L. (St. John’s wort), on vegetal and animal test systems

Perón

Mariucci

Almeida

et al. 2013

BMC Complement Altern Med

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BackgroundSt. John’s wort (Hypericum perforatum L.) is an herbaceous plant that is native to Europe, West Asia and North Africa and that is recognized and used worldwide for the treatment of mild and moderate depression. It also has been shown to be therapeutic for the treatment of burns, bruises and swelling and can be used for its wound healing, antiviral, antimicrobial, antioxidant, analgesic, hepato-protective and anxiolytic properties. The aim of this study was to evaluate the potential cytotoxic, mutagenic and antimutagenic action of H. Perforatum.MethodsMeristematic cells were used as the test system for Allium cepa L., and bone marrow cells from Rattus norvegicus, ex vivo, were used to calculate the mitotic index and the percentage of chromosomal aberration. Statistical analysis was performed using the chi-square test.ResultsThis medicinal plant had no cytotoxic potential in the vegetal test system evaluated. In the animal test system, none of the acute treatments, including intraperitoneal gavage and subchronic gavage, were cytotoxic or mutagenic. Moreover, this plant presented antimutagenic activity against the clastogenic action of cyclophosphamide, as confirmed in pre-treatment (76% reduction in damage), simultaneous treatment (95%) and post-treatment (97%).ConclusionsThus, the results of this study suggest that the administration of H. perforatum, especially by gavage similar to oral consumption used by humans, is safe and with beneficial antimutagenic potential.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of a natural antidepressant, Hypericum perforatum L. (St. John’s wort), on vegetal and animal test systems

Perón

Mariucci

Almeida

et al. 2013

BMC Complement Altern Med

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“…Hyperricum erectum, Sarcandra glabra etc. with hepatoprotective glycosides are also reported in the literature (An et al, 2009;Li et al, 2006).…”

Section: Discussionmentioning

confidence: 78%

Amelioration of isoniazid and rifampicin-induced liver toxicity by Amaranthus graecizans subsp. silvestris in rat

Ishtiaq

Afridi

Masood

2017

Bangladesh J Pharmacol

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Amaranthus graecizans subsp. silvestris, a folk medicine for the treatment of inflammation, was used to evaluate its hepatoprotective potential against rifampicin and isoniazid-induced liver damage. Wistar albino rats were divided into four groups: Group I served as control (distilled water treated), Group II served as hepatotoxic group (isoniazid 50 mg/kg and rifampicin 100 mg/kg, treated), Group III served as positive control (silymarin 100 mg/kg, treated) while Group IV served as A. graecizans subsp. silvestris extract (400 mg/kg) treated group. The results suggest that the liver markers (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin) were significantly increased in the animals of Group II. The methanolic extract showed a significant decrease in the raised liver enzymes of Group IV and encountered the liver damage caused by isoniazid and rifampicin. Histopathological examination of liver also revealed the improved architecture in the extract-treated group. Thus, the methanolic extract has potential liver protective action due to its phytochemicals.Video Clip of Methodology:8 min 33 sec: <a href="https://www.youtube.com/v/dUa_1c_S8VY">Full Screen</a> <a href="https://www.youtube.com/watch?v=dUa_1c_S8VY">Alternate</a>

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“…Scindapsus officinalis stems [31] Ammi visnaga fruits [32] Knoxia corymbosa [33] Pancratium biflorum roots [34] Panacratium biflorum flowering bulbs [35] Pancratium maritimum L. fresh bulbs [36] Peucedanum austriacum [37] Tecomella undulata bark [38] Adina rubescens leaves [39] Dryopteris fragrans [40] Staphylea bumalda leaves [20] Immunomodulatory activity inhibited the proliferation of murine B lymphocytes in vitro at 10 Hypericum henryi aerial parts [41] Hypericum erectum [42] No reported biological activity Hyperimone A Urachromone B Hypericum henryi aerial parts [41] No reported biological activity…”

Section: -O-(6 -Galloyl)-β-dglucopyranosyl-5hydroxychromonementioning

confidence: 99%

Naturally Occurring Chromone Glycosides: Sources, Bioactivities, and Spectroscopic Features

et al. 2021

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Chromone glycosides comprise an important group of secondary metabolites. They are widely distributed in plants and, to a lesser extent, in fungi and bacteria. Significant biological activities, including antiviral, anti-inflammatory, antitumor, antimicrobial, etc., have been discovered for chromone glycosides, suggesting their potential as drug leads. This review compiles 192 naturally occurring chromone glycosides along with their sources, classification, biological activities, and spectroscopic features. Detailed biosynthetic pathways and chemotaxonomic studies are also described. Extensive spectroscopic features for this class of compounds have been thoroughly discussed, and detailed 13C-NMR data of compounds 1–192, have been added, except for those that have no reported 13C-NMR data.

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Chromone glycosides and hepatoprotective constituents of Hypericum erectum

Cited by 15 publications

References 16 publications

Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of a natural antidepressant, Hypericum perforatum L. (St. John’s wort), on vegetal and animal test systems

Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of a natural antidepressant, Hypericum perforatum L. (St. John’s wort), on vegetal and animal test systems

Amelioration of isoniazid and rifampicin-induced liver toxicity by Amaranthus graecizans subsp. silvestris in rat

Naturally Occurring Chromone Glycosides: Sources, Bioactivities, and Spectroscopic Features

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