Constituents of Lepidium meyenii ‘maca’

Muhammad, Ilias; Zhao, Jianping; Dunbar, D. Chuck; Khan, Ikhlas A.

doi:10.1016/s0031-9422(01)00395-8

Cited by 139 publications

(114 citation statements)

References 11 publications

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“…TAC had the most influence on antioxidant activity because its linear correlations with FRAP, HRSA, and LPIA were statistically significant with standardized coefficients of 0.227, 0.952, and 0.747, respectively, while TPC was only linearly correlated with FRAP and LPIA with standardized coefficients of 0.861 and 0.375, respectively. Moreover, the alkaloids in maca contained several specific compounds, such as macamides, macaenes, and macaridine that have been regarded as the primary active ingredients of maca since they were first discovered [12,34,35]. The antioxidant activity of maca has also been hypothesized to be the basis of other bioactivities [9,14,17,18].…”

Section: Correlation Between Secondary Metabolites and Antioxidant Acmentioning

confidence: 99%

Correlations between Antioxidant Activity and Alkaloids and Phenols of Maca (Lepidium meyenii)

Gan

Feng

et al. 2017

Journal of Food Quality

118

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The antioxidant capacity of maca has been considered to be the basis for other bioactivities, and revealing the active antioxidant compounds would help to elucidate a variety of bioactive compounds. In this study, the correlation between the antioxidant activity of maca and secondary metabolites, including ferric reducing antioxidant potential (FRAP), hydroxyl radical scavenging ability (HRSA), lipid peroxidation inhibition ability (LPIA), total phenolic contents (TPCs), total alkaloid contents (TACs), and total sterol contents (TSCs), was investigated by measuring. Chloroform was selected to be an efficient extraction solvent for antioxidant compounds in maca by polarity fractions test. The results showed that TPC exhibited significant linear correlations ( < 0.05) to FRAP and LPIA, while TAC had significant linear correlations ( < 0.05) to FRAP, HRSA, and LPIA. These results suggested that alkaloids and phenols were the most important substances for the antioxidation of maca, of which the antioxidant effect of alkaloids seemed to be higher than that of phenols.

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Section: Correlation Between Secondary Metabolites and Antioxidant Acmentioning

confidence: 99%

Correlations between Antioxidant Activity and Alkaloids and Phenols of Maca (Lepidium meyenii)

Gan

Feng

et al. 2017

Journal of Food Quality

118

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“…In these so called macamides, the C 14 -C 18 or C 24 fatty acid residues predominate and can be fully saturated (e.g. 250-251) (McCollom et al, 2005;Muhammad et al, 2002;Wang et al, 2007). Moreover, the Zygophyllaceae family contains more complex lignanamides (e.g.…”

Section: Q10mentioning

confidence: 99%

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Boonen

Bronselaer

Nielandt

et al. 2012

Journal of Ethnopharmacology

137

109

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a b s t r a c tEthnopharmacological relevance: N-Alkylamides (NAAs) are a promising group of bioactive compounds, which are anticipated to act as important lead compounds for plant protection and biocidal products, functional food, cosmeceuticals and drugs in the next decennia. These molecules, currently found in more than 25 plant families and with a wide structural diversity, exert a variety of biologicalpharmacological effects and are of high ethnopharmacological importance. However, information is scattered in literature, with different, often unstandardized, pharmacological methodologies being used. Therefore, a comprehensive NAA database (acronym: Alkamid) was constructed to collect the available structural and functional NAA data, linked to their occurrence in plants (family, tribe, species, genus). Materials and methods: For loading information in the database, literature data was gathered over the period 1950-2010, by using several search engines. In order to represent the collected information about NAAs, the plants in which they occur and the functionalities for which they have been examined, a relational database is constructed and implemented on a MySQL back-end. Results: The database is supported by describing the NAA plant-, functional-and chemical-space. The chemical space includes a NAA classification, according to their fatty acid and amine structures. Conclusions: The Alkamid database (publicly available on the website http://alkamid.ugent.be/) is not only a central information point, but can also function as a useful tool to prioritize the NAA Q8 choice in the evaluation of their functionality, to perform data mining leading to quantitative structure-property relationships (QSPRs), functionality comparisons, clustering, plant biochemistry and taxonomic evaluations.

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“…Maca has recently been studied profusely because of the diverse pharmacological properties, such as fertility enhancer, sexual performance effects, and endurance capacity enhancer (Cicero et al 2001;BustosObregón et al 2005;Ruiz-Luna et al 2005). The maca root contains high nutritional value component (Dini et al, 1994) and several unique secondary metabolites, such as macamides, macaene, alkaloids, glucosinolates, and sterols (Ganzera et al 2002;Muhammad et al 2002;Piacente et al 2002;Cui et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

Yang

Jin

et al. 2015

Pharmaceutical Biology

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Objective: The present study investigates the effects of macamides on endurance capacity and antifatigue property in prolonged swimming mice. Materials and methods: The Balb/c mice were divided into seven groups: a control group, low-dose groups of N-benzyllinoleamide, N-benzyloleamide, and N-benzylpalmitamide, high-dose groups of these macamides. The macamides groups received the commercial products (12 and 40 mg/kg, ig), while the control group received vehicle for 21 d. On the 14th day, the mice were given the weightloaded swimming test. On the 21st day, the mice were sacrificed immediately after 90 min swimming, and some biochemical parameters were measured. Results and discussion: Compared with the control group, exhaustive swimming time was significantly prolonged in high-dose group of N-benzyloleamide (p50.05); the levels of lactic acid (LD), blood ammonia (BA), and lactate dehydrogenase (LDH) were significantly decreased (p50.05), whereas the levels of liver glycogen (LG) and non-esterified fatty acid (NEFA) were significantly increased (p50.05) in high-dose group of N-benzyloleamide. The malondialdehyde (MDA) contents in the brain, muscle, and liver were significantly decreased (p50.05), whereas superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities in the brain, muscle, and liver were significantly increased in high-dose group of N-benzyloleamide (p50.05). Conclusion:The results indicate that N-benzyloleamide has pharmaceutical property against exercise-induced fatigue, and this effect can be explained by the modulated energy metabolism and improved antioxidant status.

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Constituents of Lepidium meyenii ‘maca’

Cited by 139 publications

References 11 publications

Correlations between Antioxidant Activity and Alkaloids and Phenols of Maca (Lepidium meyenii)

Correlations between Antioxidant Activity and Alkaloids and Phenols of Maca (Lepidium meyenii)

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

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