Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

Abstract

Objective: The present study investigates the effects of macamides on endurance capacity and antifatigue property in prolonged swimming mice. Materials and methods: The Balb/c mice were divided into seven groups: a control group, low-dose groups of N-benzyllinoleamide, N-benzyloleamide, and N-benzylpalmitamide, high-dose groups of these macamides. The macamides groups received the commercial products (12 and 40 mg/kg, ig), while the control group received vehicle for 21 d. On the 14th day, the mice were given the weightloaded swimming test. On the 21st day, the mice were sacrificed immediately after 90 min swimming, and some biochemical parameters were measured. Results and discussion: Compared with the control group, exhaustive swimming time was significantly prolonged in high-dose group of N-benzyloleamide (p50.05); the levels of lactic acid (LD), blood ammonia (BA), and lactate dehydrogenase (LDH) were significantly decreased (p50.05), whereas the levels of liver glycogen (LG) and non-esterified fatty acid (NEFA) were significantly increased (p50.05) in high-dose group of N-benzyloleamide. The malondialdehyde (MDA) contents in the brain, muscle, and liver were significantly decreased (p50.05), whereas superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities in the brain, muscle, and liver were significantly increased in high-dose group of N-benzyloleamide (p50.05). Conclusion:The results indicate that N-benzyloleamide has pharmaceutical property against exercise-induced fatigue, and this effect can be explained by the modulated energy metabolism and improved antioxidant status.

Two macamide extracts relieve physical fatigue by attenuating muscle damage in mice

“…Yang et al . reported that N ‐benzyloleamide (40 mg kg −1 ), one of the macamide monomers, had pharmaceutical properties that acted against exercise‐induced fatigue . All the above studies proved to have a beneficial effect of macamides on anti‐fatigue.…”

Effect of argi+ and multi maca food supplements on sportsmen’s physical and functional capacity

“…However, ARGI+ in combination with Multi Maca supplementation more influences aerobic capacity (p = 0,047 and p = 0,048). According toYang Q et al (2016) [32] compared with the control group of mice, exhaustive swimming time was significantly prolonged in group which used a high-dose of Maca. Very important information about the effect of Maca influence indicates J.…”

Pharmacokinetics and tissue distribution of N-3- methoxybenzyl-palmitamide in rat: A macamide derived from <i>Lepidium meyenii</i>

“…In recent years, macamide has been proposed to be the biologically active substance, because of its multiple functions, such as fatty acid amide hydrolase inhibitor [5], improving sexual performance [6], endurance capacity and antifatigue [7]. So far, 22 kinds of macamide is separated and identified from Maca tuber, and N-3-methoxybenzyl-palmitamide (MPM) is a representative substance [8,9].…”