Constituents of Pachygone ovata and Pharmacological Action of its Major Leaf Alkaloid

Anti-inflammatory and antinociceptive effect of Pachygone ovata leaves

“…The nociceptive effect of P. ovata also has been justified in the formalin induced pain model. The mechanism of antiinflammatory and antinociceptive activities from P. ovata may be explained by the presence of alkaloids such as coclaurine, reticuline, norjuzophine, trilobine (Dasgupta et al 1979;Bhat et al 1980) and different components of the plant acting simultaneously and amplifying the individual effect in a complimentary manner. In our study the alkaloid fraction alone was not as significant in terms of anti-inflammatory as compared with the methanol extract; this could be due to the complex mixture of phytochemicals from the plant acting through a combination of additive and/or synergic interactions also indicating that the pharmacological effect of P. ovata is dependent on other phytochemicals apart from the alkaloids alone in it.…”

“…has been an unexplored and trivialized plant from the Menispermaceae family despite containing a number of interesting alkaloids such as coclaurine, reticuline, trilobine, pachyovatamine (benzylisoquinoline alkaloids) magnoflurine (aporphine alkaloid), norjuziphine (benzyltetrahyroisoquinoline alkaloid), liriodenine, pachygonine (erythrina alkaloid), etc. (Dasgupta et al 1979;Bhat et al 1980;El-Kawi et al 1984;Uvais et al 1985). Traditionally only its use as a fish poison and vermicide has been highlighted (Hooker 1961;Kirtikar & Basu 1975).…”

Naturally occurring plant isoquinoline N-oxide alkaloids: Their pharmacological and SAR activities

“…Reticuline N-oxide (88) was isolated from aerial parts of flowering Corydalis pseudoadunca, and total alkaloid content was 1.39% dry wt (Israilov et al 1985), and reticuline N-oxide (88) also was isolated from Pachygone ovata (Dasgupta et al 1979); it showed central stimulant, hyperthermic, and spinal convulsant actions in mice, the activity profile closely resembling that of thebaine. Reticuline was identified from Argemone albiflora, A.…”

“…The biosynthesis of this important intermediate starting from the primary metabolite, L-tyrosine, has been completely solved at the enzyme level. Reticuline N-oxide was isolated from aerial parts of flowering Corydalis pseudoadunca (Israilov et al 1985), Pachygone ovata (Dasgupta et al 1979), Monocyclanthus vignei ,…”

Infraspecific Variation and Alkaloids of Papaver Species

“…(a) N-oxides of morphine, codeine and thebaine have been isolated from P. somniferum and P. bracteatum [211 and it has been argued previously that many alkaloids are likely to exist as N-oxides [22]. Reticuline N-oxide has not been reported from Papaver species although its presence has been demonstrated in Pachygone ovata [23]. Since reticuline has been shown to be implicated in the biosynthesis of numerous Papaver alkaloids, it is probable that this is one of the N-oxides which will be found as a natural product within the genus.…”