Constituents of the Roots of Cissus rheifolia

Saifah, Ekarin; Vaisiriroj, V.; Kelley, Charles J.; Higuchi, Yoshinori

doi:10.1021/np50050a057

Cited by 7 publications

(7 citation statements)

References 2 publications

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“…In the case of the triterpenes, seven sterols were identified; β-sitosterol, stigmasta-5,22-dien-3-ol, stigmast-4-en-3-one, campesterol, brassicasterol and epicholesterol. The first two were obtained as mixture in compound 4 as previously discussed, in the case of campesterol it was isolated from hexane 30 and ethanolic extract of C. quadrangularis stems 39 and is also found in methanolic extract of the roots of C. rheifolia 26 . Stigmast-4-en-3-one was previously isolated from the ethanolic extract of C. quadrangularis stems 42 .…”

Section: Resultsmentioning

confidence: 87%

Lipid constituents fromCissus trifoliatastems

Méndez-López,

González Llerena,

Espinosa-Rodríguez

et al. 2023

Preprint

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ObjectiveThe stems from plants of the genusCissusare used in traditional medicine worldwide. In MexicoCissus trifoliatais employed for the management of several diseases, however little is known about the active compounds. The present investigation focuses on the extraction, isolation, and characterization of the lipid contents from the stems ofC. trifoliataby chromatographic, spectroscopic, and spectrometric techniques.MethodsThe hexane extract was fractionated sequentially with hexane and ethanol and visualized by TLC. The compounds were isolated by column chromatography and structurally elucidated using NMR. In addition, the complete extract and solids obtained by fractionations were analyzed by GC-MS.ResultsAccording to NMR signals, solids present in the hexane extract correspond to hentriacontane, octatetracontane, octacosanoic acid, tricosyl tetracosanoate and sitosterol. Furthermore, the analysis by GC-MS found 33 compounds, and the most abundant were hentriacontane, squalene, palmitic acid, oleic acid, β-sitosterol, and nonacosane.ConclusionThis report describes the major constituents in the hexane extract fromCissus trifoliatastems. Our analysis suggests an abundant composition of higher alkanes, fatty acids, and sterols, which are the major lipid components of cuticular waxes and plant cell membranes.

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Section: Resultsmentioning

confidence: 87%

Lipid constituents fromCissus trifoliatastems

Méndez-López,

González Llerena,

Espinosa-Rodríguez

et al. 2023

Preprint

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“…But the related compounds like protocatechuic acid hexoside and quinic acid were previously reported in C. trifoliata stem extract and C. rotundifolia aerial parts extract, respectively. [8,26] The identified flavonoids were hesperidin (8), quercitrin (9), quercetin (11), dihydrokaempferol (12), epigallocatechin (14), bergenin (15), epiafzelechin (17), vitexin (18), orientin (19), isohemiphloin (20), isovitexin (21), catechin (25), ononin (30), apigenin (31), isoschaftoside (32), kaempferol hexoside (33), naringenin (35) and myricetin (38). Quercitrin, quercetin, vitexin, orientin, isovitexin, catechin, isoschaftoside and myricetin were previously reported in C. quadrangularis L. stem extract using LC-QToF analysis.…”

Section: Hplc-esi-ms/ms Analysismentioning

confidence: 99%

“…[7][8][9][10][11] The main active constituents of Cissus species are sterols, triterpenoids, alkaloids, phenolics, flavonoids, stilbene derivatives, coumarin glycosides and iridoids. [8,[12][13][14][15][16][17][18][19][20] Many pharmacological activities were attributed to certain Cissus species, such as antimicrobial, antiulcer, antiosteoporosis, hypoglycemic, antioxidant, antitumor, analgesic, anti-inflammatory, hepatoprotective, immunomodulatory, anti-obesity, antihyperlipidemic, estrogenic, anti-arthritic and anti-allergic activities. [7,8,11,18,[21][22][23] In our search, there is no available literature about the phytochemistry and the pharmacological effect of Cissus rhombifolia Vahl.…”

Section: Introductionmentioning

confidence: 99%

“…Different Cissus species are frequently used by traditional healers to treat various health problems such as fever, fractured bones, ingestion, dyspepsia, kidney stones, and asthma [7–11] . The main active constituents of Cissus species are sterols, triterpenoids, alkaloids, phenolics, flavonoids, stilbene derivatives, coumarin glycosides and iridoids [8,12–20] …”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Profiling and Compound Isolation of Cissus rhombifolia Vahl. Leaves Aqueous Methanolic Extract with the Evaluation of Its Anti‐Inflammatory Effect Using Lipopolysaccharide‐Induced Inflammation in RAW 264.7 Cells

Raslan¹,

Mounier²

2023

Chemistry & Biodiversity

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The inflammatory disorders represent a serious health issue. Certain Cissus species possess anti-inflammatory effect. Cissus rhombifolia Vahl. leaves' anti-inflammatory activities and phytoconstituents are poorly characterized. In this study, 38 constituents were tentatively characterized in Cissus rhombifolia Vahl. leaves' aqueous methanolic extract (CRLE) using high-performance liquid chromatography combined with mass spectrometry (HPLC/MS) and Proton Nuclear Magnetic Resonance ( 1 H-NMR). Myricetin, β-amyrin, and alliospiroside A, were isolated from CRLE using column chromatography. The anti-inflammatory effect of CRLE and its isolated compounds were studied in lipopolysaccharide (LPS)-induced RAW 264.7 cells. 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT as-say) was used to assess how CRLE and its isolated compounds affected cell viability. Further, its effects on the production of intracellular NO, and inflammatory cytokines cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6) were assessed by the Griess test, and cytokine enzymelinked immunosorbent assays, respectively. CRLE and its isolated compounds, myricetin, β-amyrin, and alliospiroside A decreased the NO production. Western blotting was performed to assess the protein expression levels of the inflammatory cytokines inducible nitric oxide synthase (iNOS). Alliospiroside A downregulated IL-6, TNF-α, and COX-2 and inhibited the expression of iNOS. CRLE and its compounds represent effective alternative candidate to treat inflammatory diseases.

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“…Foram isolados alcalóides quinolizidínicos dos pigmentos dos frutos de Cissus rheifolia e uma mistura de esteróides e flavonóides 2,3 das folhas e raízes. A partir da parte aérea do Cissus quadrangularis foram isolados triterpenoides 4 ; enquanto que do Cissus pallida foi isolado o pallidol, que apresentou atividade antifúngica 5 .…”

Section: Introductionunclassified

Estudo fitoquímico e avaliação do potencial antidiabético do Cissus sicyoides L. (Vitaceae)

Beltrame¹,

Sartoretto²,

Bazotte³

et al. 2001

Quím. Nova

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Recebido em 6/10/00; aceito em 8/2/01 PHYTOCHEMICAL STUDY AND EVALUATION OF THE ANTIDIABETIC POTENTIAL OF CISSUS SICYOIDES L. (VITACEAE). The effect of hydroalcoholic extracts (HE) obtained from leaves of Cissus sicyoides (CS) on glucose tolerance (GT) was investigated in rats treated with dexametasone (DEX). Our results showed that HE intensified the decreased GT promoted by (DEX). Additionally, the flavonoids kaempferol 3-O-rhamnoside and quercetin 3-O-rhamnoside, obtained from aerial parts of CS, were used to study the incorporation of glucose to glycogen in soleo muscle. The results showed that both flavonoids did not show effect on glycogen synthesis. Thus, our data, in contrast to popular believe, did not reveal antidiabetic activity to SC.Keywords: Cissus sicyoides; Vitaceae; antidiabetic potential; flavonoids. Quim. Nova, Vol. 24, No. 6, 783-785, 2001. O pó das partes aéreas (300g) foi macerado com metanol a temperatura ambiente por oito dias. Após a destilação do solvente sob temperatura reduzida, obteve-se 33,9 g do extrato metanólico (EM). Artigo INTRODUÇÃOExtração e fracionamento.

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Constituents of the Roots of Cissus rheifolia

Cited by 7 publications

References 2 publications

Lipid constituents fromCissus trifoliatastems

Lipid constituents fromCissus trifoliatastems

Phytochemical Profiling and Compound Isolation of Cissus rhombifolia Vahl. Leaves Aqueous Methanolic Extract with the Evaluation of Its Anti‐Inflammatory Effect Using Lipopolysaccharide‐Induced Inflammation in RAW 264.7 Cells

Estudo fitoquímico e avaliação do potencial antidiabético do Cissus sicyoides L. (Vitaceae)

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