Constituintes químicos de Hyptidendron canum (Pohl ex Benth.) R. Harley (Lamiaceae)

Lemes, Geralda de Fátima; Ferri, Pedro Henrique; Lopes, Manuela

doi:10.1590/s0100-40422011000100008

Cited by 16 publications

(15 citation statements)

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“…The leaves and stems of T. urvilleana were extracted successively with hexane, EtOAc, and MeOH. Purification of the hexane extract permitted the isolation of glutinol (1) [10], taraxerol (2) [11], a mixture of α- and β-amyrins (3,4) [11b, 12], β-sitosterol, and ursolic (5) [13] and oleanolic (6) [14] acids as a mixture. From EtOAc extract only β-sitosterol was obtained.…”

Section: Resultsmentioning

confidence: 99%

“…mp 135-136 °C). Fraction D (485.0 mg), obtained with hexane-EtOAc 80:20, was purified by VCC (10 g of silica gel) using as eluent hexane-Me 2 CO 85:15 to produce 24.5 mg of white crystals constituted of a mixture of ursolic and oleanolic acids(5 and 6) [13,14]. The purification of EtOAc extract (14.9 g) by VCC (160 g of silica gel) eluted with a hexane-Me 2 CO polarity gradient only afforded β-sitosterol (22.4 mg).…”

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confidence: 99%

“…White crystals: mp 211-213 °C (Lit. [10] mp 210-213 °C, 210-212 °C); [α] D 25 +57.6 (c 0.25, CHCl 3 ); IR (KBr) ν max 3441, 2925, 2866, 1454, 1383, 1034 cm -1 ; 1 H NMR (CDCl 3 , 300 MHz) δ 5.63 (1H, br d, J = 6.0 Hz, H-6), 3.47 (1H, dd, J = 3.3, 2.4 Hz, H-3), 1.16 (3H, s, H-28), 1.14 (3H, s, H-23), 1.09 (3H, s H-26), 1.04 (3H, s, H-24), 1.00 (3H, s, H-27), 0.99 (3H, s, H-30), 0.95 (3H, s, H-29), 0.85 (3H, s, H-25);13 C NMR (CDCl 3 , 75 MHz) δ 141.6 (C-5), 122.1 (C-6), 76.3 (C-3), 49.7 (C-10), 47.4 (C-18), 43.0 (C-8), 40.8 (C-14), 39.3 (C-4), 38.9 (C-22), 37.8 (C-13), 36.0 (C-16), 35.1 (C-19), 34.8 (C-9), 34.6 (C-11), 34.5 (C-30), 33.1 (C-21), 32.4 (C-28), 32.1 (C-15), 32.0 (C-29), 30.3 (C-12), 30.1 (C-17), 28.9 (C-23), 28.2 (C-20), 27.8 (C-7), 25.5 (C-24), 23.6 (C-1), 19.6 (C-27), 18.4 (C-26), 18.2 (C-2), 16.2 (C-25); EIMS m/z (rel. int.…”

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Triterpenes and other Metabolites from Tibouchina urvilleana

Pérez-Castorena

2017

J. Mex. Chem. Soc.

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Triterpenes and other Metabolites from Tibouchina urvilleana

Pérez-Castorena

2017

J. Mex. Chem. Soc.

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“…17,50 A identificação do triterpeno 16 foi realizada por meio das técnicas de EM (inserção direta) e RMN de 1 H e 13 C e comparação com dados da literatura. 51 A mistura de 3, 8 e 9 -15 foi identificada pela análise dos espectros de massas, comparação com dados da biblioteca NIST do equipamento de CG/EM e/ou dados da literatura. [52][53] Para as substâncias 17 -21 além dos dados obtidos nos espectros de RMN de 1 H e 13 C foram utilizadas informações obtidas na análise dos dados de UV, LC/MS, EM e/ou comparação com dados da literatura.…”

Section: Determinação Estrutural Das Substânciasunclassified

Phytochemical Profile and Antioxidant activity of a Lecythis pisonis Cambess. Specimen (Lecythidaceae)

Barreto¹,

Moreira²,

Gomes³

et al. 2020

Rev. Virtual Quim.

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The species Lecythis pisonis (L. pisonis) popularly known as "sapucaia" or "cumbuca de macaco", is a plant belonging to the family Lecythidaceae. This family has interesting pharmacological activities that have driven researchers to explore their species. Observing the biological potential of the species L. pisonis, this work aimed to trace the chemical profile of its leaves and to evaluate the in vitro antioxidant (DPPH and ABTS •+) and cytotoxic activity against Artemia salina Leach larvae. Qualitative tests identified the presence of triterpenes, steroids, saponins, flavonoids, and phenolics in general. The phytochemical investigation of the leaves resulted in the identification of the mixture of triterpenes: epifriedelanol and friedelin (1+2), α-amyrin and β-amyrin (4+5), squalene (3) and ursolic acid (16); the mixture of steroids: stigmasterol and β-sitosterol (6+7); α-tocopherol (8); of the mixture of esters: methyl palmitate, ethyl palmitate, ethyl 9-octadecenoate, 9,12,15-methyl octadecanoate, butyl palmitate, ethyl octadecanoate and butyl octadecanoate (9-15); the mixture of isoquercitrin and astragalin flavonoids (20+21); gallic acid and methyl gallate (17+19); gallic acid (17) and ellagic acid (18). This the first report of the identification of substances 8-15, 17-21 in the leaves of the species L. pisonis. The evaluation of the antioxidant activity of polar extracts revealed a great antioxidant potential, which may be associated with high levels of phenols and total flavonoids. The quantification of proanthocyanidin in the extract in MeOH showed a content of 8.65 mg EC/g of crude extract. The bioassay carried out with A. salina MeOH and MeOH:H 2 O extracts showed mild toxicity. A espécie Lecythis pisonis (L. pisonis), conhecida popularmente como sapucaia ou cumbuca de macaco, é uma planta pertencente à família Lecythidaceae. Esta família possui atividades farmacológicas interessantes que têm impulsionado pesquisadores a explorar suas espécies. Observando o potencial biológico da espécie L. pisonis, este trabalho teve como objetivo traçar o perfil químico de suas folhas, avaliar a atividade antioxidante in vitro (DPPH e ABTS •+) e citotóxica contra larvas de Artemia salina Leach. Os testes qualitativos identificaram a presença de triterpenos, esteroides, saponinas, flavonoides e outros compostos fenólicos. A investigação fitoquímica das folhas resultou na identificação da mistura de triterpenos: epifriedelanol e friedelina (1+2), α-amirina e β-amirina (4+5), esqualeno (3) e ácido ursólico (16); da mistura dos esteroides: estigmasterol e β-sitosterol (6+7); α-tocoferol (8); da mistura dos ésteres: palmitato de metila, palmitato de etila, 9-octadecenoato de etila, 9,12,15-octadecanoato de metila, palmitato de butila, octadecanoato de etila e octadecanoato de butila (9-15); da mistura dos flavonoides isoquercitrina e astragalina (20+21); do ácido gálico e galato de metila (17+19); do ácido gálico (17) e ácido elágico (18). Sendo este o primeiro relato da identificação das substâncias 8-15, 17-21 nas folh...

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“…1) including four new compounds, sonnerphenolic A (1), sonnerphenolic B (2), sonnerphenolic C (23) and sonnercerebroside (3). The other compounds were identified as (-)-(R)-nyasol (4), 7 (7S,8R)-dehydroconiferyl alcohol (5), 8 (7S,8R)-5-methoxydehydroconiferyl alcohol (6), 8 (7S,8R)-urolignoside (7), 9 lingueresinol (8), 10 (+)-isolariciresinol (9), 11 (+)-isolariciresinol 9'-O-β-Dglucopyranoside (10), 12 (-)-isolariciresinol 9'-O-β-D-glucopyranoside (11), 12 (-)-episyringaresinol (12), 13 (+)-syringaresinol (13), 13 β-sitosterol (14), 4 3-O-palmitoyl-β-sitosterol (15), 4 corosolic acid (16), 14 3-O-acetylursolic acid (17), 15 6-O-galloyl-D-glucopyranose (18), 16 gallic acid 3-O-β-Dglucopyranoside (19), 17 18 1-O-benzyl-β-Dglucopyranose (21), 12 and (−)-rhodolatouchol (22) 19 via spectroscopic data analysis and comparison with those reported in the literature. In this paper, the chemical structure elucidation of four new compounds was described.…”

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confidence: 99%