Constructing an on-demand drug release system composed of thermosensitive PPP hydrogel and drug-laden alginate/graphene microspheres to treat tumorous defect

Zhuang, Yi; Kan, Zhaojun; Jiang, Yulin; He, Miaomiao; Zhang, Yuanyuan; Sun, Xiaodong; Du, Meixuan; Wang, Jing; Li, Yubao; Li, Yunfeng; Zhang, Li

doi:10.1007/s10853-022-06907-4

Cited by 5 publications

(2 citation statements)

References 72 publications

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“…Previously, drug release from nanocarriers has been mainly dependent on pH. However, most recently, Zhuang et al 225 suggested a graphene microsphere-based drug delivery platform for a 5-FU release procedure that occurs as required. This platform is made up of graphene and calcium alginate, which are mixed to produce a microsphere which is afterward coupled with 5-FU and a triblock polymer to make a heat-sensitive hydrogel abbreviated as PLGA-PEG-PLGA or PPP.…”

Section: Combined Therapiesmentioning

confidence: 99%

Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications

et al. 2023

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Section: Combined Therapiesmentioning

confidence: 99%

Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications

et al. 2023

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“…Hydrogels are insoluble biomaterial scaffolds with three-dimensional (3D) networks that can be formed through physical or chemical cross-linking [ 26 , 27 ]. Their unique features such as high biocompatibility, biodegradability, high water content, and flexible mechanical properties have made them extensively utilized in various biomedical applications, including tissue engineering, cell culture, drug delivery, biosensors, and antitumor therapy [ 28 , 29 , 30 , 31 , 32 ]. In recent years, hydrogels have garnered significant interest as drug carriers in antitumor phototherapy owing to their ability to achieve localized delivery of phototherapeutic agents while minimizing their distribution in non-target sites [ 33 , 34 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment

Gan

Zhang

et al. 2023

Gels

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Phototherapeutic agent-based phototherapies activated by light have proven to be safe modalities for the treatment of various malignant tumor indications. The two main modalities of phototherapies include photothermal therapy, which causes localized thermal damage to target lesions, and photodynamic therapy, which causes localized chemical damage by generated reactive oxygen species (ROS). Conventional phototherapies suffer a major shortcoming in their clinical application due to their phototoxicity, which primarily arises from the uncontrolled distribution of phototherapeutic agents in vivo. For successful antitumor phototherapy, it is essential to ensure the generation of heat or ROS specifically occurs at the tumor site. To minimize the reverse side effects of phototherapy while improving its therapeutic performance, extensive research has focused on developing hydrogel-based phototherapy for tumor treatment. The utilization of hydrogels as drug carriers allows for the sustained delivery of phototherapeutic agents to tumor sites, thereby limiting their adverse effects. Herein, we summarize the recent advancements in the design of hydrogels for antitumor phototherapy, offer a comprehensive overview of the latest advances in hydrogel-based phototherapy and its combination with other therapeutic modalities for tumor treatment, and discuss the current clinical status of hydrogel-based antitumor phototherapy.

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Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

Gu,

Cui,

et al. 2024

Adv Funct Materials

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Regenerative biomedicine has emerged as a forefront area in medical research, heralding a new era of therapeutic strategies. This review delineates the integration of 2D materials (2DMs) within the area of biomedical engineering, leveraging their superior physicochemical attributes for enhance biomedical outcomes. The synergistic interaction between biomacromolecules and 2DMs is explored, demonstrating their potential to mitigate the limitations inherent to each while simultaneously augmenting their beneficial properties. In particular, incorporating 2DMs into hydrogels highlights their capability to enhance the mechanical strength of hydrogels, providing a biomimetic scaffold for tissue engineering regeneration and cancer diagnosis and therapy. An overview of the synthetic methodologies are provided for 2DMs, elucidating their interaction dynamics with biomacromolecules. The review primarily concentrates on the applications of biomacromolecule‐reinforced 2DM hydrogels across various biomedical fields, including bone tissue engineering, wound healing, neural tissue engineering, cardiac tissue engineering, as well as in the delivery of drugs and genes, cancer therapy, and biosensing technologies. Finally, the review discusses the existing challenges and future outlook for developing and using biomacromolecule‐reinforced 2DM hydrogels, underlining their transformative potential in regenerative medicine.

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Constructing an on-demand drug release system composed of thermosensitive PPP hydrogel and drug-laden alginate/graphene microspheres to treat tumorous defect

Cited by 5 publications

References 72 publications

Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications

Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications

Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment

Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

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