Graphene family in cancer therapy: recent progress in cancer gene/drug delivery applications

Abstract

In the past few years, the development in the construction and architecture of graphene-based nanocomplexes has dramatically accelerated the use of nano-graphene in therapeutic and diagnostic purposes, fostering a new...

Recent Advances in Collagen Antimicrobial Biomaterials for Tissue Engineering Applications: A Review

“…However, despite the successful preclinical findings, developed dressings could not inhibit the growth of P. aeruginosa, which is one of the most common causative bacteria for wound infections [49]. On the other hand, some inorganic compounds were incorporated in biomaterial formation to increase targeted tissue regeneration and antimicrobial activity [50][51][52]. For instance, the association of collagen with bioactive glass (BG) may promote the antibacterial activity of pristine collagen by the increase in osmotic pressure, which is raised proportionally to the released ions (e.g., silicon, calcium, and phosphorous) composed of bioactive glasses.…”

Multifunctional GQDs for receptor targeting, drug delivery, and bioimaging in pancreatic cancer

“…The study showed that KRAS-targeted GQDs could significantly suppress the progress of pancreatic cancer cells and sensitized them to chemotherapy drugs. 103 Another research group synthesized GQDs coated with PEI and conjugated with siRNA-targeting survivin, a protein overexpressed in pancreatic cancer cells. The study showed that the survivin-targeted GQDs could efficiently deliver siRNA to pancreatic cancer cells and induce apoptosis.…”

“…The study showed that GQD-mediated gemcitabine delivery could enhance the intracellular accumulation and cytotoxicity of the drug, leading to improved anticancer efficacy. 103 Qi et al produced GQDs that specifically damaged the DNA of cancer cells to slow down tumor development. Nucleus-targeting TAT peptides (TAT-NGs) were used to create modified amine-functionalized GQDs, and were additionally combined with folic acid (FA)-adapted PEG by a disulfide linkage to target cancer cells.…”

Functionalization of graphenic surfaces by oxygen plasma toward enhanced wettability and cell adhesion: experiments corroborated by molecular modelling

“…The materials can be then surface-functionalized with biomolecules or bioactive substances. As a result, a broad gamut of biomedical applications emerges, such as the delivery of drugs, 9,10 genes, and proteins, as well as photothermal therapy, 11 building biosensors, 12 bioimaging, 13 antimicrobial agents, 14 and scaffolds for tissue engineering and cell cultures, 15,16 to mention the most important.…”