In response to U.S. federal mandates to increase the presence of underrepresented
populations in prevention research, investigators have increasingly focused on using
culturally sensitive research practices. However, scholars have rarely discussed these
practices in terms of a larger culturally sensitive framework. Further, while the
literature has explored how culturally sensitive approaches can be employed in a variety
of methods, there has been little examination of how to incorporate such approaches into
experimental designs. In this paper, we explain how we incorporated a culturally sensitive
framework in a cluster randomized field trial with over 3,000 predominantly low-income
Latino families, utilizing an intervention designed to improve social relations and
enhance family functioning. We offer conceptual and practical examples to guide other
researchers who want to adopt a similar approach in their research designs. In addition,
we discuss the benefits of forging local partnerships throughout the research process to
ensure respect for racial and ethnic minorities participating in social and behavioral
experimental studies. We conclude with practical considerations for utilizing a culturally
sensitive framework to advance prevention programs, policies, and practices among
underrepresented groups in order to achieve the ultimate goal of addressing the
traditional underrepresentation of racial and ethnic minorities in research.