Constructing Silk Fibroin-Based Three-Dimensional Microfluidic Devices <i>via</i> a Tape Mask-Assisted Multiple-Step Etching Technique

Zhou, Mengyuan; Shi, Xuemei; Li, Xiaobai; Xiao, Gang; Liang, Liping; Ju, Jun; Wang, Feng; Xia, Qingyou; Sun, Wei; Qiao, Yan; Yu, Ling

doi:10.1021/acsabm.1c00948

Cited by 11 publications

(2 citation statements)

References 43 publications

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“…At present, many low-cost materials have been explored to develop tools for environmental monitoring, including cellulose paper, thread, cloth and polymers (Gao et al, 2019a;Arroyo et al, 2020;Zhang et al, 2020;Zhou et al, 2021;. In fact, devices made from the first three materials have caught intensive attention and are often called paper-based analytical devices (µPADs), thread-based analytical devices (µTADs), and cloth-based analytical devices (µCADs), respectively.…”

Section: Low-cost Materialsmentioning

confidence: 99%

Low-cost microfluidics: Towards affordable environmental monitoring and assessment

Mesquita

Gong

Lin

2022

Front. Lab. Chip. Technol.

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Effective environmental monitoring has become a worldwide concern, requiring the development of novel tools to deal with pollution risks and manage natural resources. However, a majority of current assessment methods are still costly and labor-intensive. Thanks to the rapid advancements in microfluidic technology over the past few decades, great efforts have been made to develop miniaturized tools for rapid and efficient environmental monitoring. Compared to traditional large-scale devices, microfluidic approaches provide several advantages such as low sample and energy consumption, shortened analysis time and adaptabilities to onsite applications. More importantly, it provides a low-cost solution for onsite environmental assessment leveraging the ubiquitous materials such as paper and plastics, and cost-effective fabrication methods such as inkjet printing and drawing. At present, devices that are disposable, reproducible, and capable of mass production have been developed and manufactured for a wide spectrum of applications related to environmental monitoring. This review summarizes the recent advances of low-cost microfluidics in the field of environmental monitoring. Initially, common low-cost materials and fabrication technologies are introduced, providing a perspective on the currently available low-cost microfluidic manufacturing techniques. The latest applications towards effective environmental monitoring and assessment in water quality, air quality, soil nutrients, microorganisms, and other applications are then reviewed. Finally, current challenges on materials and fabrication technologies and research opportunities are discussed to inspire future innovations.

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Section: Low-cost Materialsmentioning

confidence: 99%

Low-cost microfluidics: Towards affordable environmental monitoring and assessment

Mesquita

Gong

Lin

2022

Front. Lab. Chip. Technol.

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“…While, the neighboring β-sheets in the SF molecules can stack together to form highly ordered crystalline structures, contributing to the mechanical stability and insolubility of the RSF-based materials. Since the freshly prepared RSF films are unstable and water-soluble, watervapor annealing [29,30], glycerol incorporation [31], and methanol/ethanol treatment [32,33] were usually employed to enrich β-sheets and β-crystallites for achieving the water insolubility. However, the increase of β-sheet conformations may lead to the reorganization of crystalline and amorphous domains, further affecting the elasticity of the film.…”

Section: Introductionmentioning

confidence: 99%

Partially insoluble regenerated silk fibroin film induced by UV irradiation for electronic skins

Song,

Zhou,

Sun

et al. 2023

Flex. Print. Electron.

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The regenerated silk fibroin (RSF) film has been regarded as an ideal substrate for biocompatible, flexible, and biodegradable electronic skin (e-skin) devices. However, it is still a great challenge to balance the flexibility and solubility of the RSF film by adjusting its secondary structure. Herein, a film prepared with the hydrolyzed RSF was exposed to the 254 nm ultraviolet (UV) light to prepare a crosslinked and partially water-insoluble substrate for a strain-sensing e-skin. The hydrolyzed low-molecular-weight RSF was produced by heating the LiBr-silk fibroin solution at 85°C for a certain duration. The film cast with the hydrolyzed RSF solution could be thoroughly dissolved in water rapidly. The UV irradiation could induce the crosslinking of the low-molecular-weight RSF to form insoluble substances, thus producing a partially insoluble RSF film. After silver nanowires (AgNWs) painting, an e-skin strain sensor was successfully constructed based on the UV-irradiated film. The sensor shows a fast response time (2.01 s), high sensitivity (GF=1.03 within 0-40% strain range), and good stability. The device could be tightly attached to human skin with a drop of water. The finger, wrist, elbow, and knee bending could be sensitively detected in real-time. The head nodding and mouth opening could also be sensed by sticking the e-skin at the neck and cheek, respectively. This work may provide a facile way to prepare a stretchable and stickable RSF film, which could serve as an ideal substrate of low-cost, biodegradable, direct-to-skin sensors for wearable applications.

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The Dawning Era of Anticancer Nanomedicines: From First Principles to Application of Silk Nanoparticles

Matthew,

Seib

2024

Advanced Therapeutics

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This review introduces nanomedicines and medical silks by addressing seminal and recent research within these fields. First, the successes of nanoparticles in improving the safety profiles and pharmacokinetic–pharmacodynamic properties are explored but also the concepts of threshold dosing and targeting of tumor‐associated macrophages. Current barriers to systemic delivery of nanomedicines are detailed and methods to overcome these barriers and increase tumor targeting are evaluated, namely: tuning the nanomedicine size and surface charge for enhanced tumor accumulation and penetration; non‐spherical nanomedicine morphologies for macrophage evasion and targeted delivery to endothelial cells; and, surface functionalization for stealth coatings and targeting receptor‐mediated endocytosis. The advantages of using silk as a nanomedicine with reference to its structure, composition, biological performance, and formulation are discussed. While batch methods for silk processing enable the formation of nano to microparticles, continuous technology can overcome bottlenecks of the deployed engineering methods such as low throughput and poor reproducibility. Finally, the chemical modification of silk using homogeneous and heterogenous chemistries is assessed within the nanomedicine context. Overall, this review covers silk nanomedicines from first principles to carrier design and on to areas of future development.

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Constructing Silk Fibroin-Based Three-Dimensional Microfluidic Devices via a Tape Mask-Assisted Multiple-Step Etching Technique

Cited by 11 publications

References 43 publications

Low-cost microfluidics: Towards affordable environmental monitoring and assessment

Low-cost microfluidics: Towards affordable environmental monitoring and assessment

Partially insoluble regenerated silk fibroin film induced by UV irradiation for electronic skins

The Dawning Era of Anticancer Nanomedicines: From First Principles to Application of Silk Nanoparticles

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