Objectives: Commercial photocurable polymers used in dental additive manufacturing still have mechanical limitations. The incorporation of graphene may provide interesting advantages in this field. This study aimed to evaluate in vitro the effect of adding graphene nanoparticles to a 3D-printed polymethylmethacrylate dental resin in terms of surface roughness, flexural properties, and hardness. Methods: A 3D-printed dental resin (Dental Sand, Harz Lab) was loaded with four different graphene nanoplatelet (Graphenest) concentrations: 0.01wt%, 0.1wt%, 0.25wt%, and 0.5wt%. The neat resin was used as the control group. The surface roughness was measured with a contact profilometer using bar-shaped specimens (50x10x4mm). The flexural strength of specimens (80x10x4mm) from each group was calculated using the 3-point bending test in a Universal Test Machine. Hardness shore D was measured using a manual durometer on round-shaped specimens (12x6mm). Data were evaluated using the Kruskall-Wallis test followed by post-hoc Bonferroni corrected pairwise inter-group comparisons. Statistical significance was set at p<0.05. Results: Graphene improved 3D-printed PMMA resin hardness with statistical significance at a concentration of 0.01wt% (p=0.043). Surface roughness increased with graphene concentrations above 0.01wt%, with statistically significant differences at 0.25wt% (p=0.006) and 0.5wt% (p=0.005) concentrations. Flexural properties worsened with increased graphene concentrations, and these differences were significant in the concentrations of 0.25wt% (p=0.028) and 0.5wt% (p=0.006). Conclusions: The use of graphene as a mechanical reinforcement nanomaterial seems to be viable at low concentrations without prejudice to the surface roughness of a 3D-printed polymethylmethacrylate resin.
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