Although Industry 4.0 has received much attention in recent years due to the possibility of increasing companies’ productivity, the implementation process is complex. The aim of this study is to present a holistic model for implementing Industry 4.0 based on cleaner production as a fundamental tool for the development of production systems that meet the Sustainable Development 04026-002Goals (SDGs), and social stakeholders that cooperate with this implementation process, helping to develop sustainable infrastructure, processes and technologies to increase the sustainable transformation of these companies towards Industry 4.0. The method used was literature research, and the Delphi technique was used to ask specialists to contribute with their experience to evaluate and propose improvements to the model, in the form of a consensus. The model contributes to the Sustainable Development Goals 9, 12 and 15. This holistic and sustainable model is a contribution to theory and practice, helping executives, technicians, entrepreneurs and those involved with Industry 4.0 to base the implementation process in the needs and specificities of each company, avoiding the “one fits all” models, considering the peculiarities of each company and the complexity of the implementation process in a more efficient and collaborative digital production ecosystems base, seeking to reduce inequalities, through the joint effort of social stakeholders to find ways to restore and/or improve social harmony, impacted by Industry 4.0.