Construction and analysis of protein-protein interaction network correlated with ankylosing spondylitis

Kanwal, Attiya; Fazal, Sahar

doi:10.1016/j.gene.2017.09.049

Cited by 19 publications

(12 citation statements)

References 10 publications

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“…It appears that hereditary genes play an essential significant role in the pathogenesis of AS. More than 90% of patients with AS have a particular marker that can be found on their white platelets, called human leukocyte antigen (HLA)-B27 [ 55 ]. A study screened 12,264 chemicals by using high-throughput technology to explore their effects on HLA-B27 gene promoter, and discovered two HLA-B27 suppressors (celastrol and pristimerin) derived from TWHF [ 56 ].…”

Section: Efficacy Of Triptolide In Autoimmune Diseasesmentioning

confidence: 99%

Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity

2021

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With the increasing epidemiology of autoimmune disease worldwide, there is an urgent need for effective drugs with low cost in clinical treatment. Triptolide, the most potent bioactive compound from traditional Chinese herb Tripterygium Wilfordii Hook F, possesses immunosuppression and anti-inflammatory activity. It is a potential drug for the treatment of various autoimmune diseases, but its clinical application is still restricted due to severe toxicity. In this review, the pharmacodynamic effects and pharmacological mechanisms of triptolide in autoimmune diseases are summarized. Triptolide exerts therapeutic effect by regulating the function of immune cells and the expression of cytokines through inflammatory signaling pathways, as well as maintaining redox balance and gut microbiota homeostasis. Meanwhile, the research progress on toxicity of triptolide to liver, kidney, reproductive system, heart, spleen, lung and gastrointestinal tract has been systematically reviewed. In vivo experiments on different animals and clinical trials demonstrate the dose- and time- dependent toxicity of triptolide through different administration routes. Furthermore, we focus on the strategies to reduce toxicity of triptolide, including chemical structural modification, novel drug delivery systems, and combination pharmacotherapy. This review aims to reveal the potential therapeutic prospect and limitations of triptolide in treating autoimmune diseases, thus providing guiding suggestions for further study and promoting its clinical translation.

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Section: Efficacy Of Triptolide In Autoimmune Diseasesmentioning

confidence: 99%

Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity

2021

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“…Moreover, it frequently causes aggravation in extra-articular, for instance, uveitis, psoriasis and inflammatory bowel disease [ 2 ]. More than 90% genetic role has been estimated, the strongest association being with HLA-B27 [ 3 ]. However, the detailed pathogenic role of HLA-B27 remains elusive despite the existence of multiple hypotheses.…”

Section: Introductionmentioning

confidence: 99%

Multi-target mechanism of Tripteryguim wilfordii Hook for treatment of ankylosing spondylitis based on network pharmacology and molecular docking

Zhang

Zhou

2021

Annals of Medicine

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Background: Tripteryguim wilfordii Hook (TWH) has significant anti-inflammatory and immunosuppressive properties and is widely used for treating autoimmune and inflammatory diseases. However, the multi-target mechanism of TWH on ankylosing spondylitis (AS) remains to be elucidated. Methods: Active components and their target proteins were screened from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Meanwhile, AS-related targets were obtained from the Genecards Database. After overlapping, the targets of TWH against AS were collected. Then protein-protein interaction (PPI) network and core targets analysis were conducted through STRING network platform and Cytoscape software. Moreover, molecular docking methods were utilized to confirm the high affinity between TWH and targets. Finally, DAVID online tool was used to perform gene ontology (GO) and Kyoto encyclopaedia of genes and genome (KEGG) pathway enrichment analysis of overlapping targets. Results: The TCMSP Database results showed that there were11 active components of TWH against AS. PPI network and core targets analysis suggested that ESR1, VEGF, ICAM-1, and RELA were key targets against AS. Moreover, molecular docking methods confirmed the high affinity between bioactive molecular of TWH and their targets in AS. At last, enrichment analysis indicated that TWH participates in various biological processes, such as cell-cell adhesion, regulation of cell-matrix adhesion, acute inflammatory response, via TNF-a, NF-jB and so forth signalling pathways. Conclusion: Verified by network pharmacology approach based on data mining and molecular docking methods, multi-target drug TWH may serve as a promising therapeutic candidate for AS but still needs further in vivo/in vitro experiments.

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“…However, as the exact pathogenesis is still unclear, it is thought that the pathological process of AS starts with an early inflammatory phase followed by new bone formation inducing local osteitis, cartilage erosion, bone destruction, and subsequent ankylosis. Sacroiliitis and syndesmophytes (radiographic AS) are detected by plain radiography, while earlier detection could be achieved by magnetic resonance imaging (MRI) [3].…”

Section: Introductionmentioning

confidence: 99%

miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and Outcomes

Fotoh

Noreldin

Rizk

et al. 2020

Journal of Immunology Research

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Background. Early diagnosis of ankylosing spondylitis (AS) is yet not elucidated, with a potential diagnostic glance of microRNAs (miRNAs). Aim. Study the expression profile of miRNA-451a and miRNA-125a in AS patients and their impact on disease activity and prognosis. Methods. A cross-sectional study included 55 AS patients diagnosed according to modified New York criteria in 1984 with 55 matched healthy controls. History, clinical examination, and disease activity assessment with Bath ankylosing spondylitis disease activity index (BASDAI) were done. Full laboratory and radiological assessment along with expression profile of m iRNA-451a and miRNA-125a were tabulated and analyzed. Results. Higher expression levels of miRNA-125a and lower of miRNA-451a in AS patients compared to controls. Furthermore, miRNA-125a expression was high in active AS patients compared to inactive patients and controls ( 7.0 ± 3.4 vs. 4.1 ± 2.1 vs. 2.6 ± 0.6 , p < 0.001 , respectively). miRNA-451a was significantly lower in active AS patients compared to inactive patients and controls ( 2.2 ± 1.1 vs. 4.1 ± 2.3 vs. 7.1 ± 4.5 , respectively). Both miRNAs (miRNA-125a and miRNA-451a) had evident accuracy for AS diagnosis with areas under the curve (AUC) of 0.788 and 0.802, respectively. miRNA-125a had potential impact on AS activity with AUC of 0.777. Plasma levels of both miRNAs were able to distinguish AS patients with structural damage with AUCs 0.775 and 0.692, respectively. Conclusions. Both miRNA-451a and miRNA-125a were found to be of great value as sensitive noninvasive diagnostic, prognostic, and disease burden biomarker of AS patients in Egypt with suggested further studies for future therapeutic implications.

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Construction and analysis of protein-protein interaction network correlated with ankylosing spondylitis

Cited by 19 publications

References 10 publications

Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity

Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity

Multi-target mechanism of Tripteryguim wilfordii Hook for treatment of ankylosing spondylitis based on network pharmacology and molecular docking

miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and Outcomes

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