Construction and initial evaluation of an apparatus for spatial comprehensive two-dimensional liquid-phase separations

Towards spatial comprehensive three-dimensional liquid chromatography: A tutorial review

“…described the development of a device from borofloat glass, which incorporated a flat polymer monolithic support structure for the 2 D development [16]. After filling a trench with mixture of dyes, a separation was successfully carried out based on reversed-phase chromatography.…”

“…In 2011 the Schoenmakers group demonstrated a prototype apparatus targeting spatial two-dimensional liquid-phase separations in a step towards spatial 3D-LC [16]. Almost thirty years after the concept of spatial 3D-LC was introduced, a first prototype microfluidic device for spatial 3D-LC was presented by the Eeltink group working together with Schoenmakers, see Fig.…”

Advances in Raw Material Industries for Sustainable Development Goals

“…The root of reagent-free method is to remove oil and oil products from the water by water settling out with the subse quent collection of oil by special devices: settling tanks, hydrocyclones, oil traps, etc. The main disadvantage of these apparatuses is a low degree of separation of water-oil emul sions (Diederen et al, 1998, Kou et al, 2019, Vanhoutte et al, 2011, Young et al, 1994, Zeng et al, 2016, Zhou et al, 2010. In some cases, it is advisable to use the membranes for separation of water-oil emulsions (Babiker et al, 2019).…”

Post-polymerization photografting on methacrylate-based monoliths for separation of intact proteins and protein digests with comprehensive two-dimensional liquid chromatography hyphenated with high-resolution mass spectrometry

“…To obtain higher peak capacities, comprehensive two-dimensional (2D) separation methods, such as time-based ( t LC × t LC, using a combination of columns) and spatial ( x LC × x LC, using a flat separation bed) have been developed. x LC × x LC has often been studied at low pressures in the form of thin-layer liquid chromatography (TLC) [ 1 , 2 ]. The fundamental advantage of spatial separations in terms of analyses times is that the second-dimension separations are all performed in parallel.…”