2019
DOI: 10.1002/ppsc.201900200
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Construction of a Dual Drug Carrier on the Basis of Hollow Structured Upconversion Nanoparticles for pH‐Responsive Drug Delivery and UCL/MRI Dual Mode Imaging

Abstract: A series of Gd3+ doping hollow upconversion nanoparticles NaYF4:Yb,Gd,Tm (h‐UNCP) are prepared successfully. The hollow NaYF4:Yb,Gd,Tm possess excellent upconversion luminescence (UCL) and large longitudinal relativity (r1 = 128.3 mm−1 s−1), which can be potentially used for UCL/magnetic resonance imaging (MRI) dual mode imaging. On the basis of the optimal h‐UCNP, doxorubicin hydrochloride (DOX) and methotrexate (MTX) are used as drug models to prepare a dual drug carrier. After the encapsulation of DOX on th… Show more

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Cited by 3 publications
(2 citation statements)
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“…As a result, doping representative Gd 3+ (single electrons at 4 f energy level, T1 relaxation) into the UCNP core and shell can allow them to be used as MRI contrast agents. NaYF 4 : Yb, Gd, Tm [ 92 ] and NaGdF 4 : Yb, Er, Tm@NaGdF 4 [ 93 ] UCNPs are such examples. Coating MnO 2 onto UCNPs also entails producing a bright MRI signal (T1), in which MnO 2 can be etched in a solution with a pH of 5.5–7.4, simulating the ones of the TME acid environment.…”
Section: Multimodal Imaging‐guided Cancer Therapiesmentioning
confidence: 99%
“…As a result, doping representative Gd 3+ (single electrons at 4 f energy level, T1 relaxation) into the UCNP core and shell can allow them to be used as MRI contrast agents. NaYF 4 : Yb, Gd, Tm [ 92 ] and NaGdF 4 : Yb, Er, Tm@NaGdF 4 [ 93 ] UCNPs are such examples. Coating MnO 2 onto UCNPs also entails producing a bright MRI signal (T1), in which MnO 2 can be etched in a solution with a pH of 5.5–7.4, simulating the ones of the TME acid environment.…”
Section: Multimodal Imaging‐guided Cancer Therapiesmentioning
confidence: 99%
“…Spectrally shifting, upconverting nanoparticles (UCNPs), based on NaYF 4 that show photoluminescence (PL) in the ultraviolet (UV), visible, and near-infrared (NIR) regions, have drawn considerable attention due to their potential for applications in photocatalysis, [1] bioimaging and sensing, [2][3][4][5][6] non-invasive luminescence thermometry, [7,8] drug delivery, [9][10][11] extending the absorption range of solar energy devices, [12][13][14][15] and use in other optical devices. [16][17][18] During upconversion with Yb 3+ and Er 3+ doped NaYF 4 UCNPs, the sensitizer ions (Yb 3+ ) absorb NIR photons and transfer the energy of two or more photons to an activator ion (Er 3+ ).…”
Section: Introductionmentioning
confidence: 99%