Construction of a rapid electrochemical biosensor consisting of a nanozyme/aptamer conjugate for waterborne microcystin detection

Abstract

Microcystin-LR (MC-LR) is a hepatotoxin generated by excessive proliferation of cyanobacteria, which is a threat to humans and wildlife. Therefore, the rapid detection of MC-LR is an important challenge. This...

Recent Advances in Cyanobacterial Cytotoxin Biosensors Focused on Cylindrospermopsin

“…Table 2 provides information on the characteristics of the biosensors developed for CYN detection, including the bioreagents used. Unlike cyanotoxins that have been extensively studied until recently, such as MC-LR [54,[102][103][104][105] and Saxitoxin [106][107][108][109], biosensor development for CYN remains lacking. Therefore, in addition to the electrochemical and optical detection studies presented in this paper, it is urgent to actively promote research to detect CYN toxins harmful to the environment and biological systems by integrating various detection platforms and nanomaterials, bioreceptors, and microfluidic technologies.…”

“…Moreover, research on enhancing their functionality for onsite applications is ongoing. To achieve rapid detection, Park et al [54] significantly reduced the reaction time of the target analyte, MC-LR, with the bioreceptor, from 3 h to 10 min by using an alternating current electrothermal flow, thereby greatly reducing the overall detection time. Research has also been conducted to amplify signals and detect substances at ultralow concentrations by introducing nanomaterials onto the electrode surface to enhance sensitivity [55,56].…”