Construction of a reconfigurable DNA nanocage for encapsulating a TMV disk

Zhang, Tianran; Zeng, Xiaoyu; Guan, Shuwen; Li, Xiumei; Qu, Zhiyu; Qin, Luyao; Hou, Chunxi

doi:10.1039/c9cc03109j

Cited by 7 publications

(8 citation statements)

References 17 publications

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“…In the adapted Glazer-like notation, e.g. as used by Hayward, 103 the tilt system here is a⁻b 0 c 0 /b 0 a⁻c 0 . Aleksandrov 25 undertook a comprehensive group-theoretical analysis of tilting in RP phases, using a different, but equivalent, notation and designated this tilt system 00/0⁻0; we shall use the Glazer-like notation.…”

Section: Structures With a Single Type Of Octahedral Tilt And No Laye...mentioning

confidence: 99%

Structural chemistry of layered lead halide perovskites containing single octahedral layers

McNulty

Lightfoot

2021

IUCrJ

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We present a comprehensive review of the structural chemistry of hybrid lead halides of stoichiometry APbX 4, A 2PbX4 or A A′PbX 4, where A and A′ are organic ammonium cations and X = Cl, Br or I. These compounds may be considered as layered perovskites, containing isolated, infinite layers of corner-sharing PbX 4 octahedra separated by the organic species. First, over 250 crystal structures were extracted from the CCDC and classified in terms of unit-cell metrics and crystal symmetry. Symmetry mode analysis was then used to identify the nature of key structural distortions of the [PbX 4]∞ layers. Two generic types of distortion are prevalent in this family: tilting of the octahedral units and shifts of the inorganic layers relative to each other. Although the octahedral tilting modes are well known in the crystallography of purely inorganic perovskites, the additional layer-shift modes are shown to enormously enrich the structural options available in layered hybrid perovskites. Some examples and trends are discussed in more detail in order to show how the nature of the interlayer organic species can influence the overall structural architecture; although the main aim of the paper is to encourage workers in the field to make use of the systematic crystallographic methods used here to further understand and rationalize their own compounds, and perhaps to be able to design-in particular structural features in future work.

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Section: Structures With a Single Type Of Octahedral Tilt And No Laye...mentioning

confidence: 99%

Structural chemistry of layered lead halide perovskites containing single octahedral layers

McNulty

Lightfoot

2021

IUCrJ

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“…Various DNA origami architectures including squares, [23,24] triangles, [25][26][27] disks, [28] cubes, [29] boxes, [30,31] wireframes [32] have been made since Rothemund first reported DNA origami [33] . Benefiting from sequential specificity and spatial addressability, DNA origami offers an ideal platform to attach proteins at predefined sites via a set of immobilization strategies such as non-specific electrostatic adsorption, [34] site-specific assembly of DNA modified protein, [35] or direct assembly assisted by protein tags, [36] aptamers, [37] antibody-antigen binding, [38] and enzymatic ligation, [39] showing fantastic designability and accuracy for protein manipulation.…”

Section: Dna Origami Structure Classificationmentioning

confidence: 99%

DNA Origami‐Based Protein Manipulation Systems: From Function Regulation to Biological Application

Huang

Yin

et al. 2022

ChemBioChem

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Proteins directly participate in tremendous physiological processes and mediate a variety of cellular functions. However, precise manipulation of proteins with predefined relative position and stoichiometry for understanding protein‐protein interactions and guiding cellular behaviors is still challenging. With superior programmability of DNA molecules, DNA origami technology is able to construct arbitrary nanostructures that can accurately control the arrangement of proteins with various functionalities to solve these problems. Herein, starting from the classification of DNA origami nanostructures and the category of assembled proteins, we summarize the existing DNA origami‐based protein manipulation systems (PMSs), review the advances on the regulation of their functions, and discuss their applications in cellular behavior modulation and disease therapy. Moreover, the limitations and potential directions of DNA origami‐based PMSs are also presented, which may offer guidance for rational construction and ingenious application.

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“…In the experiment for protection of mitochondria against oxidative stress, the TMV-based disk and the tubelike nanoenzyme showed a more antioxidative effect than the GPx mimic of 2-SeCD when the same activity of enzyme mimics was used. We then verified the encapsulation of the TMV nanodisk in a DNA nanocage by opening and closing of the DNA nanocage (Figure b) . When the fuel strand was added, the DNA nanocage opened by unfolding of the DNA hairpin, and after the addition of the antifuel strand was performed, the DNA hairpin refolds to lead to the close of DNA nanocage.…”

Section: Modifications Of Virusmentioning

confidence: 99%

Section: Modifications Of Virusmentioning

confidence: 99%

“…We then verified the encapsulation of the TMV nanodisk in a DNA nanocage by opening and closing of the DNA nanocage (Figure 3b). 51 When the fuel strand was added, the DNA nanocage opened by unfolding of the DNA hairpin, and after the addition of the antifuel strand was performed, the DNA hairpin refolds to lead to the close of DNA nanocage. When the origin of assembly (OAS, a strand of TMV RNA) was introduced into the opening DNA nanocage, through the interactions between TMVcp and OAS, the TMV disk with 18 nm binds and is then encapsulated in the closed DNA nanocage.…”

Section: Scheme 1 Modification Strategies For Supramolecular Virus As...mentioning

confidence: 99%

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Virus-Based Supramolecular Structure and Materials: Concept and Prospects

Hou

Jiang

et al. 2021

ACS Appl. Bio Mater.

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Rodlike and spherelike viruses are various monodisperse nanoparticles that can display small molecules or polymers with unique distribution following chemical modifications. Because of the monodisperse property, aggregates in synthetic protein−polymer nanoparticles could be eliminated, thus improving the probability for application in protein−polymer drug. In addition, the monodisperse virus could direct the growth of metal materials or inorganic materials, finding applications in hydrogel, drug delivery, and optoelectronic and catalysis materials. Benefiting from the advantages, the virus or viruslike particles have been widely explored in the field of supramolecular chemistry. In this review, we describe the modification and application of virus and viruslike particles in surpramolecular structures and biomedical research.

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Construction of a reconfigurable DNA nanocage for encapsulating a TMV disk

Abstract: A new reconfigurable DNA nanocage based on a DNA origami method has been constructed to capture a tobacco mosaic virus (TMV) disk.

Cited by 7 publications

References 17 publications

Structural chemistry of layered lead halide perovskites containing single octahedral layers

Structural chemistry of layered lead halide perovskites containing single octahedral layers

DNA Origami‐Based Protein Manipulation Systems: From Function Regulation to Biological Application

Virus-Based Supramolecular Structure and Materials: Concept and Prospects

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