Construction of Ag-incorporated coating on Ti substrates for inhibited bacterial growth and enhanced osteoblast response

Yuan, Zhangfu; Liu, Peng; Hao, Yansha; Ding, Yao; Cai, Kaiyong

doi:10.1016/j.colsurfb.2018.07.064

Cited by 38 publications

(29 citation statements)

References 51 publications

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“…Further modification may also enhance the antibacterial ability. After photo-assisted deposition, Yuan et al104 fabricated a layer of bioactive polyelectrolyte multilayer films of CHI and dialdehyde alginate on the surface of the AgNP-doped TNTs using the spin-associated layer-by-layer technique. This coating significantly reduced the burst release, and the contained CHI also exerted a synergistic effect with Ag + to enhance the antibacterial property.…”

Section: Doping With Other Antibacterial Agentsmentioning

confidence: 99%

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

Yang

et al. 2019

IJN

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Prosthesis-associated infections are one of the main causes of implant failure; thus it is important to enhance the long-term antibacterial ability of orthopedic implants. Titanium dioxide nanotubes (TNTs) are biomaterials with good physicochemical properties and biocompatibility. Owing to their inherent antibacterial and drug-loading ability, the antibacterial application of TNTs has received increasing attention. In this review, the process of TNT anodizing fabrication is summarized. Also, the mechanism and the influencing factors of the antibacterial property of bare TNTs are explored. Furthermore, different antibacterial strategies for carrying drugs, as well as modifications to prolong the antibacterial effect and reduce drug-related toxicity are discussed. In addition, antibacterial systems based on TNTs that can automatically respond to infection are introduced. Finally, the currently faced problems are reviewed and potential solutions are proposed. This review provides new insight on TNT fabrication and summarizes the most advanced antibacterial strategies involving TNTs for the enhancement of long-term antibacterial ability and reduction of toxicity.

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Section: Doping With Other Antibacterial Agentsmentioning

confidence: 99%

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

Yang

et al. 2019

IJN

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“…[48] The HA, chitosan, and dialdehyde alginate have been coated on the Ag-NTs surface to protect the tissue surrounding from the direct contact with Ag without hindering the antibacterial properties of the implant. [160,174] The antibacterial mechanisms of AgNPs are still not completely understood. Many studies show that Ag + , free Ag radicals, and AgNPs all exhibit antibacterial effects.…”

Section: Ag-incorporated Coatingmentioning

confidence: 99%

“…[ 48 ] The HA, chitosan, and dialdehyde alginate have been coated on the Ag‐NTs surface to protect the tissue surrounding from the direct contact with Ag without hindering the antibacterial properties of the implant. [ 160,174 ]…”

Section: Ion‐incorporated Coating On Ti For Enhanced Osteogenic and Amentioning

confidence: 99%

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Zhao

et al. 2020

Adv Healthcare Materials

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Bone fracture is prevalent among athletes and senior citizens and may require surgical insertion of bone implants. Titanium (Ti) and its alloys are widely used in orthopedics due to its high corrosion resistance, good biocompatibility, and modulus compatible with natural bone tissues. However, bone repair and regrowth are impeded by the insufficient intrinsic osteogenetic capability of Ti and Ti alloys and potential bacterial infection. The physicochemical properties of the materials and nano/microstructures on the implant surface are crucial for clinical success and loading with biofunctional elements such as Sr, Zn, Cu, Si, and Ag into nano/microstructured TiO 2 coating has been demonstrated to enhance bone repair/regeneration and bacterial resistance of Ti implants. In this review, recent advances in biofunctional element-incorporated nano/microstructured coatings on Ti and Ti alloy implants are described and the prospects and limitations are discussed.

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“…Moreover, even more recently, silver nanoparticles have been adopted to open up new-avenues for biocompatible nano-medicines. In this connection, ecofriendly technologies are emerging as potential anti-infective strategies in searching for alternatives to conventional antibiotics [28,29,30,31,32,33]. Ag + is an environmentally friendly antimicrobial, as (i) it is highly toxic for a wide range of micro-organisms [34], (ii) it is non-toxic (in low concentrations) for human cells, (iii) bacteria are not able to develop resistance, as Ag + attacks a broad range of targets in organisms, and thus, resistance should involve several simultaneous mutations [35].…”

Section: Introductionmentioning

confidence: 99%

High Bactericidal Self-Assembled Nano-Monolayer of Silver Sulfadiazine on Hydroxylated Material Surfaces

et al. 2019

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Anti-infective surfaces are a modern strategy to address the issue of infection related to the clinical use of materials for implants and medical devices. Nanocoatings, with their high surface/mass ratio, lend themselves to being mono-layered on the material surfaces to release antibacterial molecules and prevent bacterial adhesion. Here, a “layer-by-layer” (LbL) approach to achieve a self-assembled monolayer (SAM) with high microbicidal effect on hydroxylated surfaces is presented, exploiting the reaction between a monolayer of thiolic functions on glass/quartz surfaces and a newly synthesized derivative of the well-known antibacterial compound silver sulfadiazine. Using several different techniques, it is demonstrated that a nano-monolayer of silver sulfadiazine is formed on the surfaces. The surface-functionalized materials showed efficient bactericidal effect against both Gram-positive and Gram-negative bacteria. Interestingly, bactericidal self-assembled nano-monolayers of silver sulfadiazine could be achieved on a large variety of materials by simply pre-depositing glass-like SiO2 films on their surfaces.

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Construction of Ag-incorporated coating on Ti substrates for inhibited bacterial growth and enhanced osteoblast response

Cited by 38 publications

References 51 publications

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

<p>Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques</p>

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

High Bactericidal Self-Assembled Nano-Monolayer of Silver Sulfadiazine on Hydroxylated Material Surfaces

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