High Bactericidal Self-Assembled Nano-Monolayer of Silver Sulfadiazine on Hydroxylated Material Surfaces

Abstract

Anti-infective surfaces are a modern strategy to address the issue of infection related to the clinical use of materials for implants and medical devices. Nanocoatings, with their high surface/mass ratio, lend themselves to being mono-layered on the material surfaces to release antibacterial molecules and prevent bacterial adhesion. Here, a “layer-by-layer” (LbL) approach to achieve a self-assembled monolayer (SAM) with high microbicidal effect on hydroxylated surfaces is presented, exploiting the reaction between a monolayer of thiolic functions on glass/quartz surfaces and a newly synthesized derivative of the well-known antibacterial compound silver sulfadiazine. Using several different techniques, it is demonstrated that a nano-monolayer of silver sulfadiazine is formed on the surfaces. The surface-functionalized materials showed efficient bactericidal effect against both Gram-positive and Gram-negative bacteria. Interestingly, bactericidal self-assembled nano-monolayers of silver sulfadiazine could be achieved on a large variety of materials by simply pre-depositing glass-like SiO2 films on their surfaces.

Antialgal Synergistic Polystyrene Blended with Polyethylene Glycol and Silver Sulfadiazine for Healthcare Applications

“…The PSPS10 blend with 10% SS and 10% PEG concentration has shown the lowest contact angle, i.e., 43 °. The decrease in the contact angle of PSPS10 is due to presence of hydroxyl group in PEG and polarity of SS that tends to increase the hydrophilic nature of PSP10 [31,32].…”

Self-Assembled Monolayers of Copper Sulfide Nanoparticles on Glass as Antibacterial Coatings

“…An enormous number of papers have been published on the surface modification or coating of a variety of materials, with the aim of making them intrinsically antibacterial and with the ability to fight the growth of biofilms. In a huge list of cases, modification and coating were based on an approach involving inorganic chemistry and antibacterial elements such as silver and to a lesser extent, copper [4][5][6][7][8]. Metal ions, in fact, offer multiple ways of interference with bacteria survival and replication (binding and damaging of cell walls, generation of oxygen reactive species, interaction with DNA) and so the generation of mutations able to equip bacterial strains with resistance to these agents is extremely difficult: for example, resistance to silver is rare and develops much slower than that to antibiotics, which usually work with only one mechanism [9].…”

Strategies for Improving Antimicrobial Properties of Stainless Steel

“…Many different approaches have been attempted to thwart microbial corrosion [ 100 ], to counteract bacterial adhesion [ 101 ] or to confer bactericidal or antibacterial properties to the material surfaces [ 102 , 103 ], while also improving biological responses, such as hemocompatibility [ 101 , 103 ]. Future research will undoubtedly be aimed at optimizing the biological performances of materials, such as SS, by modifying their surfaces.…”