Construction of an in vivo carotid siphon model for testing endovascular devices for neuro-interventions

Gao, Bu-Lang; Wang, Yongli; Zhang, Xue‐Jing; Fan, Qingyu; Hao, Wei-Li; Zhang, Donghai

doi:10.1177/1591019916688649

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…However, these methods are not without complications, including dissection, as in our case, and potential worsening occlusive pathology. Additionally, delivery of a single balloon-mounted DES to the MCA is limited by the tortuosity and osseous encasement of the carotid siphon [20].…”

Section: Discussionmentioning

confidence: 99%

Tandem Short-length Multi-stent Construct for Emergent Revascularization of Occlusive Long-segment Left Middle Cerebral Artery In-stent Stenosis

Karsonovich

Bolt²,

Gordhan

2020

Cureus

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Endovascular stenting and balloon angioplasty is a feasible although controversial option for intracranial atherosclerotic stenosis refractory to maximize medical management. High rates of symptomatic in-stent restenosis (ISR) have been identified with Wingspan stent (Stryker, Fremont, CA, USA) placement. Revascularization of ISR by way of re-stenting is often attempted, albeit with high risk and low durability. In lesions with long-segment non-focal critical or emergent occluded stenosis, re-stenting with a single balloon mounted stent is not possible due to deliverability of a lengthy device through a tortuous carotid siphon. Tandem drug-eluting stent placement within the middle cerebral artery to address acute, occlusive ISR using a Wingspan stent, with additional stent reconstruction, has not been previously described.

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Section: Discussionmentioning

confidence: 99%

Tandem Short-length Multi-stent Construct for Emergent Revascularization of Occlusive Long-segment Left Middle Cerebral Artery In-stent Stenosis

Karsonovich

Bolt²,

Gordhan

2020

Cureus

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Application of nondestructive mechanical characterization testing for creating in vitro vessel models with material properties similar to human neurovasculature

Norris

Merritt

Becker

2021

J Biomedical Materials Res

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Vessel models are a first step in developing endovascular medical devices. However, these models, often made from glass or silicone, do not accurately represent the mechanical properties of human vascular tissue, limiting their use to basic training and proof-of-concept testing. This study outlines methods to quantify human vascular tissue mechanical properties and synthetic biomaterials for creating representative vessel models. Human vascular tissue was assessed and compared to silicone and new UV-cured polymers (VC-A30) using the following eight mechanical tests: compressive, shear, tensile dynamic elastic modulus, Poisson's ratio, hardness, radial force, compliance, and lubricity. Half of these testing methods were nondestructive, allowing for multiple mechanical and histological characterizations of the same human tissue sample. Histological evaluation of the cellular and extracellular matrix of the human vessels verified that the dynamic moduli and Poison's ratio tests were nondestructive. Fluid absorption by VC-A30 showed statistically significant softening of mechanical properties, stabilizing after 4 days in phosphate-buffered saline (PBS).Human vasculature exhibited notably similar results to VC-A30 in five of eight mechanical tests (≤30% difference) versus two of eight for standard silicone (≤38% difference). Results show that VC-A30 provides a new option for 3D-printing translucent in vitro vascular models with anatomically relevant mechanical properties. These new vessel analogs may simulate patient-specific vessel disease states, improve surgical training models, accelerate new endovascular device developments, and ultimately reduce the need for animal models.

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Evaluation of vessel injury after simulated catheter use in an endothelialized silicone model of the intracranial arteries

et al. 2023

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Construction of an in vivo carotid siphon model for testing endovascular devices for neuro-interventions

Cited by 3 publications

References 5 publications

Tandem Short-length Multi-stent Construct for Emergent Revascularization of Occlusive Long-segment Left Middle Cerebral Artery In-stent Stenosis

Tandem Short-length Multi-stent Construct for Emergent Revascularization of Occlusive Long-segment Left Middle Cerebral Artery In-stent Stenosis

Application of nondestructive mechanical characterization testing for creating in vitro vessel models with material properties similar to human neurovasculature

Evaluation of vessel injury after simulated catheter use in an endothelialized silicone model of the intracranial arteries

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