Construction of Liposomes Mimicking Cell Membrane Structure through Frame‐Guided Assembly

Wang, Chao; Piao, Jiafang; Li, Yujie; Tian, Xiancheng; Dong, Yuanchen; Li, Dongsheng

doi:10.1002/anie.202005334

Cited by 39 publications

(38 citation statements)

References 70 publications

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“…Recently, Liu and co‐workers successfully constructed liposomes mimicking cell membrane structure based on FGA (Figure 9b). [ 163 ] They used transmembrane α‐helices peptide as LHG to guide the assembly of lipid. Due to the hydrophobic matching interaction between transmembrane peptides and phospholipids, cell structure‐like liposomes were successfully obtained.…”

Section: Membrane Formation Guided By Dna Nanostructuresmentioning

confidence: 99%

“…b) Liposome guided by transmembrane peptide–DNA; Reproduced with permission. [ 167 ] Copyright 2020, Wiley‐VCH GmbH. c) Liposomes whose size is determined by using DNA nanostructures as exoskeleton templates.…”

Section: Membrane Formation Guided By Dna Nanostructuresmentioning

confidence: 99%

mentioning

confidence: 99%

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Recent Progress of DNA Nanostructures on Amphiphilic Membranes

Piao

Yuan

Dong

2021

Macromolecular Bioscience

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Employing DNA nanostructures mimicking membrane proteins on artificial amphiphilic membranes have been widely developed to understand the structures and functions of the natural membrane systems. In this review, the recent developments in artificial systems constructed by amphiphilic membranes and DNA nanostructures are summarized. First, the preparations and properties of the amphipathic bilayer models are introduced. Second, the interactions are discussed between the membrane and the DNA nanostructures, as well as their coassembly behaviors. Next, the alternative systems related to membrane protein‐mediated signal transmission, selective distribution, transmembrane channels, and membrane fusion are also introduced. Moreover, the constructions of membrane skeleton protein‐mimicking DNA nanostructures are also highlighted.

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Section: Membrane Formation Guided By Dna Nanostructuresmentioning

confidence: 99%

Section: Membrane Formation Guided By Dna Nanostructuresmentioning

confidence: 99%

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Recent Progress of DNA Nanostructures on Amphiphilic Membranes

Piao

Yuan

Dong

2021

Macromolecular Bioscience

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“…Inorganic nanomaterials themselves have adjuvant properties, which can stimulate the body to produce an immune response and assist the therapeutic effect of tumor vaccines (Nguyen et al, 2019 ). In recent years, the third generation of nanomedicine has gradually emerged, also known as intelligent nanomachines, including natural materials such as exosomes, cell membranes, bacterial outer membrane vesicles, and microparticles for preclinical research, as well as nanomachine drugs prepared by DNA framework self-assembly, DNA origami and other precise and controllable carrier synthesis technologies, which have the characteristics of environmental responsiveness, focal active recognition, and specific response, and thus have strong clinical application value and prospects (Liang et al, 2019 ; Wang et al, 2020 ; Li et al, 2018 ) ( Figure 3 ).…”

Section: Inorganic Nanomaterialsmentioning

confidence: 99%

Research progress of the engagement of inorganic nanomaterials in cancer immunotherapy

Peng

Liu

2022

Drug Delivery

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Cancer has attracted widespread attention from scientists for its high morbidity and mortality, posing great threats to people’s health. Cancer immunotherapy with high specificity, low toxicity as well as triggering systemic anti-tumor response has gradually become common in clinical cancer treatment. However, due to the insufficient immunogenicity of tumor antigens peptides, weak ability to precisely target tumor sites, and the formation of tumor immunosuppressive microenvironment, the efficacy of immunotherapy is often limited. In recent years, the emergence of inorganic nanomaterials makes it possible for overcoming the limitations mentioned above. With self-adjuvant properties, high targeting ability, and good biocompatibility, the inorganic nanomaterials have been integrated with cancer immunotherapy and significantly improved the therapeutic effects.

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“…The incorporation of biomimetic frame would result in the programmable construction of artificial compartments with morphological heterogeneity. [ 45 ] Lipid vesicles could encapsulate cell‐free systems for triggered protein expressions with a high efficiency. [ 46 ] The practical superiority of vesicles is in the compatible incorporation with functional membrane proteins.…”

Section: Compartmentmentioning

confidence: 99%

Emerging Advances of Cell‐Free Systems toward Artificial Cells

et al. 2020

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models have attracted considerable attentions in order to unravel the inherent complexity. Although engineering modern cells has achieved some progress, [2] the arbitrary elimination of genomic information could probably remove some distinguished characteristics (top-down strategy). Building chemical systems that resemble the structure and behaviors of living cells by stepwise integration of pivotal components is also conceivable (bottom-up strategy). [3] These synthetic systems with biomimetic cellularity provide conceptual pathway from inanimate matter to artificial life, which are often known as artificial cells. [4] Due to the lack of full comprehension about the molecular mechanism of living cells, laborious reconstitution of complicated networks would be difficult and the disparities of protein behaviors in the artificial cells have been observed. Herein, we prefer to construct artificial cells by preserving certain endogenous machinery already existing in living cells. Such principle is conducible for maintaining essential features of living cells while leaving design space for synthetic biologists to study specific cellular behavior in bottom-up manner. [5] Cell-free system, also referred to as in vitro transcription and translation system is a universal toolbox to study the organisms of cell biology. [6] Cell-free extracts inherit most of the endogenous machinery including functional macromolecules as well as metabolic networks and the addition of desired resources could initiate coupled protein expressions. Indeed, the first appearance of cell-free systems could date back to 1961 when Nirenberg and Matthaei deciphered the genetic codes. [7] Featured by the accessible utilization of molecular machinery, cellfree systems could circumvent the frangibility and membrane barrier of biological cells. The transformative development of protein synthesis using recombinant elements (PURE) system with well-defined components greatly enhances the systemic manipulation and controllability. [8] In principle, the quintessence behind cell-free system is the central dogma that reflects the flow of genetic information, from plasmid DNA to messenger RNA (mRNA), to eventually make functional proteins. As such, artificial cells encapsulated with cell-free system could serve as the valuable candidate to construct numerous biological processes. [9] The powerful ability of protein expressions, which is deprived in other synthetic systems, offers advantageous scenario for enzymatic processes that are also guided by flexible and programmable regulations of gene circuit. [10] The execution of larger genetic programs could further permit the construction of complex biochemical systems. [11] More importantly, Artificial cells that mimic the architectural and functional characteristics of living cells not only shed light on the physical principle of life but also facilitate development in the areas such as cell engineering and biomedicine. Cell-free systems carry out the central dogma that refers to the transcription and translation ...

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Construction of Liposomes Mimicking Cell Membrane Structure through Frame‐Guided Assembly

Cited by 39 publications

References 70 publications

Recent Progress of DNA Nanostructures on Amphiphilic Membranes

Recent Progress of DNA Nanostructures on Amphiphilic Membranes

Research progress of the engagement of inorganic nanomaterials in cancer immunotherapy

Emerging Advances of Cell‐Free Systems toward Artificial Cells

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