Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapy

Ding, Hong; Zhang, Xiang; Liu, Zheng; Wang, Juehan; Zhu, Ce; Chen, Qian; Huang, Yong; Ai, Youwei; Wu, Ruibang; Feng, Ganjun; Zhang, Li; Liu, Limin

doi:10.1016/j.matdes.2022.111493

Cited by 8 publications

(1 citation statement)

References 26 publications

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“…MOF@PH satisfactorily inhibited IVDD progression in a rat model. 111 Wang et al associated H 2 therapy with hollow polydopamine (HPDA) to achieve sustained H 2 release from a degenerated disc. They used HPDA as a pH-responsive carrier and developed ammonia borane (AB) as a source of H 2 .…”

Section: Enzyme-responsive Systemmentioning

confidence: 99%

Stimuli-Responsive Delivery Systems for Intervertebral Disc Degeneration

Tang,

Luo,

Wang

et al. 2024

IJN

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As a major cause of low back pain, intervertebral disc degeneration is an increasingly prevalent chronic disease worldwide that leads to huge annual financial losses. The intervertebral disc consists of the inner nucleus pulposus, outer annulus fibrosus, and sandwiched cartilage endplates. All these factors collectively participate in maintaining the structure and physiological functions of the disc. During the unavoidable degeneration stage, the degenerated discs are surrounded by a harsh microenvironment characterized by acidic, oxidative, inflammatory, and chaotic cytokine expression. Loss of stem cell markers, imbalance of the extracellular matrix, increase in inflammation, sensory hyperinnervation, and vascularization have been considered as the reasons for the progression of intervertebral disc degeneration. The current treatment approaches include conservative therapy and surgery, both of which have drawbacks. Novel stimuli-responsive delivery systems are more promising future therapeutic options than traditional treatments. By combining bioactive agents with specially designed hydrogels, scaffolds, microspheres, and nanoparticles, novel stimuli-responsive delivery systems can realize the targeted and sustained release of drugs, which can both reduce systematic adverse effects and maximize therapeutic efficacy. Trigger factors are categorized into internal (pH, reactive oxygen species, enzymes, etc.) and external stimuli (photo, ultrasound, magnetic, etc.) based on their intrinsic properties. This review systematically summarizes novel stimuli-responsive delivery systems for intervertebral disc degeneration, shedding new light on intervertebral disc therapy.

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Section: Enzyme-responsive Systemmentioning

confidence: 99%

Stimuli-Responsive Delivery Systems for Intervertebral Disc Degeneration

Tang,

Luo,

Wang

et al. 2024

IJN

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Encapsulated phenolic compounds: clinical efficacy of a novel delivery method

Ozkan,

Ceyhan,

Çatalkaya

et al. 2024

Phytochem Rev

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Encapsulation is a drug or food ingredient loaded-delivery system that entraps active components, protecting them from decomposition/degradation throughout the processing and storage stages and facilitates their delivery to the target tissue/organ, improving their bioactivities. The application of this technology is expanding gradually from pharmaceuticals to the food industry, since dietary bioactive ingredients, including polyphenols, are susceptible to environmental and/or gastrointestinal conditions. Polyphenols are the largest group of plants' secondary metabolites, with a wide range of biological effects. Literature data have indicated their potential in the prevention of several disorders and pathologies, ranging from simpler allergic conditions to more complex metabolic syndrome and cardiovascular and neurodegenerative diseases. Despite the promising health effects in preclinical studies, the clinical use of dietary polyphenols is still very limited due to their low bioaccessibility and/or bioavailability. Encapsulation can be successfully employed in the development of polyphenol-based functional foods, which may improve their bioaccessibility and/or bioavailability. Moreover, encapsulation can also aid in the targeted delivery of polyphenols and may prevent any possible adverse events. For the encapsulation of bioactive ingredients, several techniques are applied such as emulsion phase separation, emulsification/internal gelation, film formation, spray drying, spray-bed-drying, fluid-bed coating, spray-chilling, spray-cooling, and melt injection. The present review aims to throw light on the existing literature highlighting the possibility and clinical benefits of encapsulated polyphenols in health and disease. However, the clinical data is still very scarce and randomized clinical trials are needed before any conclusion is drawn. Graphical abstract

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