Construction of multi-scale vascular chips and modelling of the interaction between tumours and blood vessels

Abstract

Here, we constructs a whole vascular system, from arteries and capillaries to veins with a high resolution 3D printing. A bulk breast tumor tissue with a functional vascular network was built. The interaction between tumors and vessels is investigated.

Grafting of 3D Bioprinting to In Vitro Drug Screening: A Review

“…Reproduced with permission. [ 58 ] Copyright 2019, The Royal Society of Chemistry. Aiv) Schematic of the microchannel fabrication process and display of the endothelial cell‐seeded microchannels in various forms.…”

“…Reproduced with permission. [ 58 ] Copyright 2019, The Royal Society of Chemistry. Bvi) Schematic of the 3D bioprinting of hydrogel‐based hepatic construct and images showing patterns of cells within the hepatic model.…”

“…[ 56a ] He et al presented a method of engineering a microfluidic network in hydrogels via a micromolding process and enzymatic‐crosslinking mechanism (Figure 4Aiii). [ 56i,58 ] Song et al proposed a method in which one kind of hydrogel was printed within another kind of hydrogel due to the properties of shear‐thinning and self‐healing (Figure 4Aiv). [ 56b ]…”

“…[ 54d ] Nie et al constructed a breast cancer model containing tumor stroma, a functional vascular system, and tumor cells (Figure 4Bv). [ 58 ]…”

“…Several critical processes during tumor development were reproduced based on a parallel‐channel model containing the tumor stroma, a chemical environment, a functional vascular system, and tumor cells (Figure 5Cv). [ 58 ]…”