Construction of poly(dopamine) doped oligopeptide hydrogel

Abstract

Incorporation of poly(dopamine) (PDA) into the native oligopeptide hydrogel has been demonstrated to decrease the critical gel concentration (CGC), improve the rigidity of formed hybrid hydrogel, and especially endow the hydrogel with efficient free radical scavenging ability.Inspired by nature, self-assembly strategy has been well developed to build various biomaterials in recent years. For example, self-assembly of DNA, 1,2 phospholipids, 3,4 proteins, 5,6 as well as peptides 7 has been widely exploited to construct different nanomaterials for drug/gene delivery, cell culture and tissue engineering. Among them, the oligopeptides with low molecular weights have attracted much attention in the eld of nanotechnology-assistant cancer treatments due to the mellow synthetic methods and adjustable amphipathy to fabricate shape-tailored nanomaterials via self-assembly. Of note, selfassembled oligopeptide hydrogel has been demonstrated as an interesting so material for biomedical applications. 8,9Nevertheless, restricted by the short sequences, most oligopeptides are lack of multiple bioactivity. On account of the noncovalent interactions, in addition, the hydrogel strength is usually far from satisfactory. 10,11To tackle these difficulties, various hybrid oligopeptide hydrogels have been developed to hold different synergistic properties. Incorporation of graphene oxide (GO) into a short peptide hydrogel improved the rigidity of the hybrid hydrogel system compared to the native one.12 The hybrid hydrogel constructed by GO sheets and an oligopeptide possessed high drug-sustainability and on-demand drug release in vivo. 13Doping FEFEFKFK peptide hydrogel with poly(Nisopropylacrylamide)-FEFEFKFK conjugate allowed for optimizing the mechanical properties of peptide-based hydrogels and endowed them with temperature sensitivity.14 Hybrid hydrogel compromising of an amphipathic oligopeptide and a uorescent p-conjugated poly(para-phenylene vinylene) exhibited strong uorescence, even higher than the pure polymer in solution.15 As anticipated, different functions have been achieved in those two-in-one hybrid systems. Nevertheless, the controversy on the toxicity of GO in vivo slows its progress toward clinical biomaterials.16-18 And preparing functional polymers sometimes needs tedious steps. Thus, functional polymers with good biocompatibility and simple fabrication process are highly pursued to construct novel hybrid oligopeptide hydrogels.Poly(dopamine) (PDA) owing to many functional groups such as catechol, amine, and imine exhibits robust adhesion to diverse substrates, which provides great potential as the coating materials.19,20 It has been well documented that PDA could adsorb various dye molecules due to the hydrogen bonding and p-p stacking interaction. 21,22 Recently, PDA has caused serious concerns in biomedical applications due to the outstanding biocompatibility and unique physicochemical properties. 23,24PDA has been demonstrated to be an efficient antioxidant in the biological system, which is associated wit...

Polydopamine-Assisted Two-Dimensional Molybdenum Disulfide (MoS2)-Modified PES Tight Ultrafiltration Mixed-Matrix Membranes: Enhanced Dye Separation Performance

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Wood‐Derived Carbon Materials and Light‐Emitting Materials

“…[ 56–62 ] Most wood‐derived light‐emitting materials are photoluminescent, suggesting that they will emit fluorescence or phosphorescence upon light irradiation. [ 63–65 ] The main focus of this section is fluorescent and phosphorescent wood‐derived materials including fluorescent CDs, anti‐ACQ materials, and CPL materials.…”

Novel oligopeptide nanoprobe for targeted cancer cell imaging

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