Construction of Promethazine Hydrochloride Selective Electrodes in A Pvc Matrix Membrane

Al-Saidi, Khaleda H.; Ahmed, Zainab W.

doi:10.22401/jnus.14.4.02

Cited by 7 publications

(4 citation statements)

References 4 publications

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“…The synthesis of ionic selective electrodes for promethazine hydrochloride with molybdophosphoric acid also involved the utilization of various plasticizers: dibutyl phthalate (DBPH), dibutyl phosphate (DBP), dioctyl phthalate (DOP), and tributyl phosphate (TBP) (9). Furthermore, the synthesis of a highly sensitive and selective electrode for promethazine incorporated the use of ammonium phosphomolybdate (10).…”

Section: Methodsmentioning

confidence: 99%

Determination of Micro Amounts of Promethazine Hydrochloride in Pure and Pharmaceutical Samples Using UV- Visible Spectrophotometry

HUMEİDY

2024

Journal of the Turkish Chemical Society Section A: Chemistry

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This study presents the development of a novel, facile, and overly sensitive spectrophotometric approach for quantifying promethazine hydrochloride (PRO) within its pharmaceutical formulations. The method capitalizes on an oxidative coupling reaction, achieved through the oxidation of the compound in an acidic milieu utilizing ammonium cerium (IV) sulfate dehydrate (Ce+4) solution. This process leads to the creation of a green-colored solution, which, upon conjugation with 5-aminosalicylic acid, exhibits maximum absorption at a wavelength of 598 nm. The methodology investigated several parameters, encompassing oxidation duration, temperature, quantities of oxidizing agent and coupling reagent, and determining the stoichiometric ratio between promethazine hydrochloride and 5-aminosalicylic acid. The established ratio was confirmed to be 1:1. Numerous organic solvents were evaluated, with water emerging as the optimal choice due to its pronounced absorption characteristics at the 598 nm wavelength. The applicability of Beer's law was verified over a concentration range of 2 - 28 μg/mL of promethazine hydrochloride, with a calculated molar absorption coefficient of 1.9606 x 104 L/mol∙cm. The Sandell sensitivity index was determined as 0.0164 μg/cm2, while the relative standard deviation (RSD) ranged from 0.8553- 1.2671%. Notably, recovery percentages were also within the 99.88 – 100.34% range. The efficacy of this technique was effectively demonstrated through its successful application in the analysis of pharmaceutical formulations containing promethazine hydrochloride, employing the standard method as a benchmark.

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Section: Methodsmentioning

confidence: 99%

Determination of Micro Amounts of Promethazine Hydrochloride in Pure and Pharmaceutical Samples Using UV- Visible Spectrophotometry

HUMEİDY

2024

Journal of the Turkish Chemical Society Section A: Chemistry

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“…The membrane got ready by dipping in 0.1 M standard solution of ciprofloxacin hydrochloride at minimum 2 hours before use for measurements [10]. Selectivity Measurements Selectivity coefficient was calculated by separate solution method by applying the equation: [11,12] Log K pot A,B = [(EB − EA) / (2.303RT/zF)]+(1 − zA/zB) logaA the potentias EA, EB; charge numbers zA, zB; and activities, aB,for interfering B ions and aA for the main A.…”

Section: Methodsmentioning

confidence: 99%

Synthesis New Liquid Selective Electrodes of Ciprofloxacin Hydrochloride for Determination Ciprofloxacin in Pure form and Pharmaceuticals Preparation.

Journal¹

2017

Baghdad Sci.J

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New membrane electrodes for determination of ciprofloxacin hydrochloride were prepared depending on ciprofloxacin hydrochloride - phosphotungstic acid (CFH-PT) as an active material and these electrodes were made with three plasticizers: Di-octylphenylphosphonate(DOPH), Di-butyl phosphate (DBP)Tri-n-butyl phosphate(TBP), in PVC matrix. One of the ciprofloxacin electrodes was gave Nernstian slope equal to 57.21 mV/ decade for DOPH membrane with concentration range from 1.5×10-5 to1.0×10-1 M, and detection limit equal to 1.5×10-6 M .Lifetime was 93 days. Non- Nernstian responses equal to 39.40 and 30.70 mV/ decade for membranes DBP, TBP, respectively. These electrodes were gave concentration range from 1.0× 10-5 to 1.0×10-2 and from 4.0×10-5 to 1.0×10-2 M,respectively. Detection limits were 7.0×10-6, and 1.7×10-6M, respectively. Lifetimes were 5,2 days, respectively. Also selectivity, influence of PH and samples analysis of ciprofloxacin in a pharmaceutical preparations were studied.

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“…From this membrane could prepare about 10 electrodes. Tube of glass was filled 3 /4 stock solution 0.1 M of drug M [13]. …”

Section: Preparation Of Membranementioning

confidence: 99%

Preparation Pilocarpine Hydrochloride Selective Electrodes

Abass

2017

JNUS

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New eight selective electrodes of pilocarpine hydrochloride deepened on complexes of (PCH) -molybdophosphoric acid and (PCH) -phosphotungstate were prepared with varied plasticizers. Electrode with complex (DBPH-MP) was used as an active material, gave linear range from 5.0×10 -2 to 6.0×10 -5 M, and slope was 62.01 mV/decade, with detection limit was 2.0×10 -5 M, lifetime was near to 60 days. Electrode , s membrane made with active material (DBP-MP), showed concentration range was 2.1×10 -3 -6.3×10 -5 M, the slope was near to 52.34 mV/decade. Detection limit was 1.0×10-5 M, 55 days was the life time of this electrode. The parameters of electrode deepened on (DBPH-PT), concentration range was from 5.0×10 -2 to 6.5×10 -5 M with slope 50.41 mV/decade, 2.2×10 -5 M was the detection limit.Life time was determined around to 52 days.

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Construction of Promethazine Hydrochloride Selective Electrodes in A Pvc Matrix Membrane

Cited by 7 publications

References 4 publications

Determination of Micro Amounts of Promethazine Hydrochloride in Pure and Pharmaceutical Samples Using UV- Visible Spectrophotometry

Determination of Micro Amounts of Promethazine Hydrochloride in Pure and Pharmaceutical Samples Using UV- Visible Spectrophotometry

Synthesis New Liquid Selective Electrodes of Ciprofloxacin Hydrochloride for Determination Ciprofloxacin in Pure form and Pharmaceuticals Preparation.

Preparation Pilocarpine Hydrochloride Selective Electrodes

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