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Method is established for simultaneous determination of Amiloride hydrochloride (Amilo) and hydrochlorothiazide in tablets. The method is based on employing normal and derivative spectrophotometry using the zero order via described by measuring the absorbance at 361 nm and the first order derivative spectra at peak 340 and valley 382 nm for (Amilo), while the zerocrossing method is applied for hydrochlorothiazide. The first order derivative absorption spectra at valleys 285 and 239 nm were used for hydrochlorothiazide. No interferences found between both determined and those of matrices. A good accuracy and precision of simultaneous determination of (Amilo), and hydrochlorothiazide were confirmed by statistical analysis. The percentage recovery of the individual drags under the established conditions is ranged from 97.79% to 101.5 %. Linearity is maintained within a wide concentration range from 2.00 mg/L to 40.00 mg/L for Amiloride hydrochloride and hydrochlorothiazide. The detection limit was 0.5 and 1.0 mg/L for Amiloride hydrochloride and hydrochlorothiazide respectively.

New polymeric membrane electrodes has been developed for the determination of Clarithromycin. The electrodes were constructed by incorporating the Clarithromycintetraphenylborate ion pair complex into a polyvinylchloride matrix plasticized by four plasticizers, Di-octyl phthalate (DOP); Di-butyl phosphate (DBP); Acetophenone (AP); Di-butyl phthalate (DBPH). These electrodes give sub-Nernstian slopes (51.206, 53.930, 58.104 and 58.484 mV/decade) and linear ranges from (1×10 -5 -1×10 -3 , 1×10 -5 -1×10 -3 , 5×10 -5 -1×10 -3 and 1×10-5 -1×10 -3 M) respectively. The best electrode was based on DBPH plasticizer which gave a slope 58.484 mV/decade, correlation coefficient 0.9961, detection limit of 9×10-6 M, lifetime 20 day and displayed good stability and reproducibility and used to determine the Clarithromycin in pharmaceutical samples. The interferences measurements were studied using the separated method for selectivity coefficient determination. The pH and life time of the electrodes were also studied.

Promethazine hydrochloride selective electrodes were constructed based on promethazine-Molybdophosphoric acid ion pair. Promethazine hydrochloride electrodes (1, 2, 3, 4 and 5) using these plasticizers Di-butyl phthalate (DBPH); Di-octyl phthalate (DOP); Di-butyl phosphate (DBP); Tri-butyl phosphate (TBP); ortho-nitro phenyl octyl ether (ONPOE) in PVC matrix respectively. These electrodes give slopes (57.27, 54.08, 49.79, 46.76 and 44.52 mV/decade) and give linear ranges from (1×10-5-1×10-1 , 1×10-4-1×10-1 , 1×10-5-1×10-1 , 5×10-4-1×10-1 and 1×10-4-1×10-1 M) respectively. The best detection limit was 6×10 −6 M for the electrode based on DBPH. The measurement interferences in the presence of (

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