Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment

Brandon, Esther; Oomen, Agnes G.; Rompelberg, C.J.M.; Versantvoort, Carolien H.M.; Engelen, J.G.M. van; Sips, A. J. A. M.

doi:10.1016/j.yrtph.2005.10.002

Cited by 110 publications

(65 citation statements)

References 6 publications

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“…RIVM is a commonly used in vitro method for BA assessment, which was developed by the Dutch National Institute for Public Health and the Environment (RIVM) [22][23][24]. The simulated solutions are shown in Table 2.…”

Section: Rivm Methodsmentioning

confidence: 99%

“…The BA of lead was calculated by dividing the amount in the simulated human body liquids by the total amount in the toy materials [22]. Quality control and quality assurance were tested via a processing method blank, laboratory fortified blank, and laboratory fortified matrix.…”

Section: Rivm Methodsmentioning

confidence: 99%

“…The BA of lead was calculated by dividing the amount in the simulated human body liquids by the total amount in the toy materials [22]. The BA calculations were conducted with the RIVM methods introduced previously.…”

Section: Ba Of Pb With Rivm Methodsmentioning

confidence: 99%

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Total lead content and its bioaccessibility in base materials of low-cost plastic toys bought on the Beijing market

Kang

Zhu

2013

J Mater Cycles Waste Manag

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The neurological hazards of lead are wellknown. Few studies have focused on lead content in plastic toys, especially in China. Therefore, this study aimed to determine total lead content in low-cost plastic toys bought in Beijing, based on the bioaccessibility (BA) of lead through an in vitro leaching method. A total of 27 of the 72 items (37.5 %) examined exceeded the American toy safety limit (100 mg/kg), but HCl extraction results showed that all the samples met the Chinese standard (\90 mg/kg). The BA of lead ranged from 0.80 to 8.86 %, with averages of 1.53 ± 0.74, 3.65 ± 1.28, 4.09 ± 1.83 and 2.62 ± 0.82 % for diluted HCl and three other leaching solutions, respectively. Our results indicated that the bioavailability risk of lead in plastic toys might be underestimated, as the HCl extraction was regulated under the standard procedures of toy safety testing. Total Pb content measurement combined with RIVM methods would be helpful in efforts to reduce children's exposure to toxic heavy metals.

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Section: Rivm Methodsmentioning

confidence: 99%

Section: Rivm Methodsmentioning

confidence: 99%

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Total lead content and its bioaccessibility in base materials of low-cost plastic toys bought on the Beijing market

Kang

Zhu

2013

J Mater Cycles Waste Manag

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“…Recently, the in vitro model has been widely used to study the bioaccessibility and risk assessment of heavy metals, persistent organic pollutants, mycotoxins from soils, toys, food, herbal medicine, cosmetics, etc. [12][13][14][15][16][17]. The Fenghuang mining area in western Hunan province, China, has one of the largest known geochemical concentrations of mercury, lead, and zinc in China.…”

Section: Introductionmentioning

confidence: 99%

Bioaccessibility and Risk Assessment of Cadmium from Uncooked Rice Using an In Vitro Digestion Model

Yang

Zhang

et al. 2011

Biol Trace Elem Res

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Cadmium (Cd)-contaminated rice is one of the most important sources of cadmium exposure in the general population from some Asian countries. This study was conducted to assess cadmium exposure from uncooked rice in rural mining areas based on the bioaccessible fraction of cadmium using an in vitro digestion model. The biotoxic effects of cadmium in uncooked rice from mining areas were much higher than those in the control area, based not only on their higher total concentration (52.49 vs. 7.93 μg kg −1 ), but also on their higher bioaccessibility (16.94% vs. 2.38%). In the mining areas, the bioaccessible fraction of cadmium in uncooked rice has a significant positive correlation with the total concentration of cadmium in rice and there was quarterly unsafe rice to the public in the mining areas. The results indicated that the in vitro digestion model could be a useful and economical tool for providing the solubilization or bioaccessibility of uncooked rice in the mining area. The results could be helpful in conducting future experiments of cooked rice in the vitro model.

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“…Various factors in the lumen influence digestion including ionic strength, pH, digestive enzymes, bile, microbiota, transit time, hydrodynamics and the composition of the food matrix (Brandon et al, 2006). Fluid models that simulate the human GI tract can provide useful ways of evaluating certain aspects of NM digestion including bioaccessibility, stability, dissolution and aggregation (Cockburn et al, 2012).…”

Section: In Vitro Non-cellular Fluid Modelsmentioning

confidence: 99%

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Venema²,

et al. 2014

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Engineered metal/mineral, lipid and biochemical macromolecule nanomaterials (NMs) have potential applications in food. Methodologies for the assessment of NM digestion and bioavailability in the gastrointestinal tract are nascent and require refinement. A working group was tasked by the International Life Sciences Institute NanoRelease Food Additive project to review existing models of the gastrointestinal tract in health and disease, and the utility of these models for the assessment of the uptake of NMs intended for food. Gastrointestinal digestion and absorption could be addressed in a tiered approach using in silico computational models, in vitro non-cellular fluid systems and in vitro cell culture models, after which the necessity of ex vivo organ culture and in vivo animal studies can be considered. Examples of NM quantification in gastrointestinal tract fluids and tissues are emerging; however, few standardized analytical techniques are available. Coupling of these techniques to gastrointestinal models, along with further standardization, will further strengthen methodologies for risk assessment.

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Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment

Cited by 110 publications

References 6 publications

Total lead content and its bioaccessibility in base materials of low-cost plastic toys bought on the Beijing market

Total lead content and its bioaccessibility in base materials of low-cost plastic toys bought on the Beijing market

Bioaccessibility and Risk Assessment of Cadmium from Uncooked Rice Using an In Vitro Digestion Model

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

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