Consumption of a diet rich in<i>Brassica</i>vegetables is associated with a reduced abundance of sulphate-reducing bacteria: A randomised crossover study

Kellingray, Lee; Tapp, Henri S.; Saha, Shikha; Doleman, Joanne F.; Narbad, Arjan; Mithen, Richard

doi:10.1002/mnfr.201600992

Cited by 66 publications

(58 citation statements)

References 41 publications

(48 reference statements)

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“…Despite the individualized responses, four taxa were associated with the cruciferous vegetable diet: Eubacterium hallii , Phascolarctobacterium faecium , Alistipes putredinis , and Eggerthella spp. In another study also feeding cruciferous vegetables, the authors reported significant reductions in sulfate-reducing bacteria [ 65 ]. This is desirable, since sulfate is reduced to hydrogen sulfide by sulfate-reducing bacteria, which has been associated with several GI disorders [ 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

Role of whole grains versus fruits and vegetables in reducing subclinical inflammation and promoting gastrointestinal health in individuals affected by overweight and obesity: a randomized controlled trial

Kopf

Suhr

Clarke

et al. 2018

Nutr J

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BackgroundWhole grains (WG) and fruits and vegetables (FV) have been shown to reduce the risk of metabolic disease, possibly via modulation of the gut microbiota. The purpose of this study was to determine the impact of increasing intake of either WG or FV on inflammatory markers and gut microbiota composition.MethodsA randomized parallel arm feeding trial was completed on forty-nine subjects with overweight or obesity and low intakes of FV and WG. Individuals were randomized into three groups (3 servings/d provided): WG, FV, and a control (refined grains). Stool and blood samples were collected at the beginning of the study and after 6 weeks. Inflammatory markers [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), lipopolysaccharide binding protein (LBP), and high sensitivity C-reactive protein (hs-CRP)] were measured. Stool sample analysis included short/branched chain fatty acids (S/BCFA) and microbiota composition.ResultsThere was a significant decrease in LBP for participants on the WG (− 0.2 μg/mL, p = 0.02) and FV (− 0.2 μg/mL, p = 0.005) diets, with no change in those on the control diet (0.1 μg/mL, p = 0.08). The FV diet induced a significant change in IL-6 (− 1.5 pg/mL, p = 0.006), but no significant change was observed for the other treatments (control, − 0.009 pg/mL, p = 0.99; WG, − 0.29, p = 0.68). The WG diet resulted in a significant decrease in TNF-α (− 3.7 pg/mL; p < 0.001), whereas no significant effects were found for those on the other diets (control, − 0.6 pg/mL, p = 0.6; FV, − 1.4 pg/mL, p = 0.2). The treatments induced individualized changes in microbiota composition such that treatment group differences were not identified, except for a significant increase in α-diversity in the FV group. The proportions of Clostridiales (Firmicutes phylum) at baseline were correlated with the magnitude of change in LBP during the study.ConclusionsThese data demonstrate that WG and FV intake can have positive effects on metabolic health; however, different markers of inflammation were reduced on each diet suggesting that the anti-inflammatory effects were facilitated via different mechanisms. The anti-inflammatory effects were not related to changes in gut microbiota composition during the intervention, but were correlated with microbiota composition at baseline.Trial registrationClinicalTrials.gov, NCT02602496, Nov 4, 2017.Electronic supplementary materialThe online version of this article (10.1186/s12937-018-0381-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Role of whole grains versus fruits and vegetables in reducing subclinical inflammation and promoting gastrointestinal health in individuals affected by overweight and obesity: a randomized controlled trial

Kopf

Suhr

Clarke

et al. 2018

Nutr J

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“…Burton et al, also found that there was an absence of the probiotic bacterial strains related to the two-week consumption of probiotic yoghurt after a three week wash-out period (n = 14) [39]. In a study by Kellingray et al, increased consumption of Brassica was associated with reduced relative abundance of sulphate-producing bacteria and members of Rikenellaceae, Ruminococcaceae, Mogibacteriaceae, and Clostridiales [40]. Though, they observed little evidence of carry-over effects of high-Brassica diet after a two-week wash-out periods.…”

Section: Effect Of Short-term Dietary Interventions On the Gut Microbmentioning

confidence: 96%

Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration

et al. 2019

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The human gut is inhabited by trillions of microorganisms composing a dynamic ecosystem implicated in health and disease. The composition of the gut microbiota is unique to each individual and tends to remain relatively stable throughout life, yet daily transient fluctuations are observed. Diet is a key modifiable factor influencing the composition of the gut microbiota, indicating the potential for therapeutic dietary strategies to manipulate microbial diversity, composition, and stability. While diet can induce a shift in the gut microbiota, these changes appear to be temporary. Whether prolonged dietary changes can induce permanent alterations in the gut microbiota is unknown, mainly due to a lack of long-term human dietary interventions, or long-term follow-ups of short-term dietary interventions. It is possible that habitual diets have a greater influence on the gut microbiota than acute dietary strategies. This review presents the current knowledge around the response of the gut microbiota to short-term and long-term dietary interventions and identifies major factors that contribute to microbiota response to diet. Overall, further research on long-term diets that include health and microbiome measures is required before clinical recommendations can be made for dietary modulation of the gut microbiota for health.

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“…To minimize confounding factors (especially various disease status), we used search terms "diet" AND "gut microbiome" AND "healthy adult" and included only clinical studies in healthy participants that have detailed diet and gut microbiome information (Supplemental Figure 2). We identi ed 16 eligible clinical studies [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53] that included in total 771 subjects. Among them, 428 were females and 343 were males.…”

Section: Diet Could Potentially Affect the E Cacy Of Cancer Immunothementioning

confidence: 99%

Relating Gut Microbiome and Its Modulating Factors to Immunotherapy in Solid Tumors: A Systematic Review

Huang

Liu

et al. 2020

Preprint

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Background: Gut microbiome is proved to affect the activity of immunotherapy in certain tumors. However, little is known if there is universal impact on both the treatment response and adverse effects (AEs) of immune checkpoint inhibitors (ICIs) across multiple solid tumors, and whether such impact can be modulated by common gut microbiome modifiers, such as antibiotics and diet.Methods: A systematic search in PubMed followed by stringent manual review were performed to identify clinical cohort studies that evaluated the relevance of gut microbiome to ICIs (response and/or AEs, 12 studies), or association of antibiotics with ICIs (17 studies), or impact of diet on gut microbiome (16 studies). Only original studies published in English before April 1st, 2020 were used. Qualified studies identified in the reference were also included.Results: At the phylum level, patients who had enriched abundance in Firmicutes and Verrucomicrobia almost universally had better response from ICIs, whereas those who were enriched in Proteobacteria universally presented with unfavorable outcome. Mixed correlations were observed for Bacteroidetes in relating to treatment response. Regarding the AEs, Firmicutes correlated to higher incidence whereas Bacteroidetes were clearly associated with less occurrence. Interestingly, across various solid tumors, majority of the studies suggested a negative association of antibiotic use with clinical response from ICIs, especially within 1-2 month prior to the initiation of ICIs. Finally, we observed a significant correlation of plant-based diet in relating to the enrichment of “ICI-favoring” gut microbiome (P = 0.0476).Conclusions: Gut microbiome may serve as a novel modifiable biomarker for both the treatment response and AEs of ICIs across various solid tumors. Further study is needed to understand the underlying mechanism, minimize the negative impact of antibiotics on ICIs, and gain insight regarding the role of diet so that this important lifestyle factor can be harnessed to improve the therapeutic outcomes of cancer immunotherapy partly through its impact on gut microbiome.

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Consumption of a diet rich inBrassicavegetables is associated with a reduced abundance of sulphate-reducing bacteria: A randomised crossover study

Cited by 66 publications

References 41 publications

Role of whole grains versus fruits and vegetables in reducing subclinical inflammation and promoting gastrointestinal health in individuals affected by overweight and obesity: a randomized controlled trial

Role of whole grains versus fruits and vegetables in reducing subclinical inflammation and promoting gastrointestinal health in individuals affected by overweight and obesity: a randomized controlled trial

Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration

Relating Gut Microbiome and Its Modulating Factors to Immunotherapy in Solid Tumors: A Systematic Review

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