Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration

Leeming, Emily R; Johnson, Abigail; Spector, Tim D.; Roy, Caroline

doi:10.3390/nu11122862

Cited by 599 publications

(404 citation statements)

References 116 publications

Supporting

Mentioning

387

Contrasting

Unclassified

Order By: Relevance

“…Our data, including metabolomic profiling, suggest that the pathology of inflammatory diseases initiated or caused by exposure to environmental pollutants (e.g., dioxin‐like PCBs) is complex and may involve disturbances in the gut microbiota, liver, and vascular tissues (Deng et al., 2019; Petriello et al, 2018). The literature, including our data, also suggest that nutritional intervention can modulate the gut microbiota (Leeming et al, 2019; Petriello et al., 2018). This suggests that positive lifestyle changes, such as healthful nutrition, can have a disease‐reducing impact already at the level of the gut microbiota.…”

supporting

confidence: 76%

Healthful nutrition as a prevention and intervention paradigm to decrease the vulnerability to environmental toxicity or stressors and associated inflammatory disease risks

Hennig

Deng

2020

Food Frontiers

View full text Add to dashboard Cite

Many noncommunicable diseases, such as atherosclerosis and other cardiometabolic diseases, are defined as inflammatory diseases, which suggests that multifactorial interactions linked to exacerbated disease pathology include pro-inflammatory chemical and nonchemical stressor. Recent data suggest that genetic and lifestyle factors are independently associated with susceptibility to cardiovascular diseases (Khera et al., 2016;Satija et al., 2018;Tong, 2016). Thus, potential biological interactions between chemical and nonchemical stressors and buffers and other lifestyle factors will determine disease outcome. Chemical stressors include environmental pollutants with pro-oxidant and pro-inflammatory properties, such as air pollutants, both gaseous and particulate matter, and persistent organic pollutants, such as dioxinlike polychlorinated biphenyls (PCBs). Many persistent organic pollutants also have an affinity for the aryl hydrocarbon receptor (AhR).AhR ligands lead to induction of cytochrome P450s and free radical formation, followed by inflammation. For example, dioxin-like PCBs can increase endothelial cell dysfunction, activation, and inflammation (e.g., increased adhesion molecule expression and cytokine production)

show abstract

supporting

confidence: 76%

Healthful nutrition as a prevention and intervention paradigm to decrease the vulnerability to environmental toxicity or stressors and associated inflammatory disease risks

Hennig

Deng

2020

Food Frontiers

View full text Add to dashboard Cite

show abstract

“…Several studies found differences in the baseline microbiome of responders versus nonresponders to different diet interventions. Additionally, individuals with differing bacterial gene richness appear to have differing baseline gut microbiota communities that respond distinctively to a given dietary intervention which will influence the diversity of the gut microbe-derived specialized metabolites and circulating metabolites [127][128][129][130][131][132][133][134][135][136].…”

Section: Gut Microbiome/absorptionmentioning

confidence: 99%

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis

Coras

Murillo-Saich

Gumá

2020

Cells

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability. Although recent pharmaceutical advances have improved the treatment of RA, patients often inquire about dietary interventions to improve RA symptoms, as they perceive pain and/or swelling after the consumption or avoidance of certain foods. There is evidence that some foods have pro- or anti-inflammatory effects mediated by diet-related metabolites. In addition, recent literature has shown a link between diet-related metabolites and microbiome changes, since the gut microbiome is involved in the metabolism of some dietary ingredients. But diet and the gut microbiome are not the only factors linked to circulating pro- and anti-inflammatory metabolites. Other factors including smoking, associated comorbidities, and therapeutic drugs might also modify the circulating metabolomic profile and play a role in RA pathogenesis. This article summarizes what is known about circulating pro- and anti-inflammatory metabolites in RA. It also emphasizes factors that might be involved in their circulating concentrations and diet-related metabolites with a beneficial effect in RA.

show abstract

“…[37] Increased α-diversity has been associated with foods generally considered as healthy, such as plant consumption or red wine. [38][39][40] Furthermore, commonly used medications such as antibiotics or proton pump inhibitors can decrease gut α-diversity. [41] Regarding the speci c taxonomy of the gut microbiome, the genus Flavonifractor was enriched in βblocker users in both the full and PS-matched cohorts.…”

Section: Discussionmentioning

confidence: 99%

Differences in the Microbial Composition of Hemodialysis Patients Treated With and Without β-Blockers

Lin

Hung

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: β-blockers are commonly prescribed medications to treat cardiovascular disease and prevent sudden cardiac death during hemodialysis. Beyond the medication effects on the host, no study has investigated the impact of β-blocker on the gut microbiota in hemodialysis patients. Results: The β-blocker users had a higher proportion of diabetes mellitus, hypertension, dyslipidemia, coronary artery disease, heart failure, cerebrovascular disease, and concurrent medications than non-users. After propensity score (PS) matching, there were no differences in comorbidities and concomitant medications. The α-diversity (Simpson index) increased in β-blocker users with a distinct β-diversity (Bray-Curtis Index) compared to non-users in the full cohort and PS-matched cohort. In the linear discriminative analysis effect size analysis and zero-inflated Gaussian fit model, there was a significant enrichment in the genus Flavonifractor in β-blocker users compared to non-users in the full cohort and PS-matched cohort; this was confirmed by random forest analysis. Conclusions: Hemodialysis patients using β-blocker used had a different gut microbiota composition compared to non-users, in particular, the Flavonifractor genus was significantly increased with β-blocker treatment. These findings highlight the significant impact of β-blockers on the gut microbiome in hemodialysis patients. Further research is warranted regarding the mechanisms and their clinical consequences.

show abstract

Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration

Cited by 599 publications

References 116 publications

Healthful nutrition as a prevention and intervention paradigm to decrease the vulnerability to environmental toxicity or stressors and associated inflammatory disease risks

Healthful nutrition as a prevention and intervention paradigm to decrease the vulnerability to environmental toxicity or stressors and associated inflammatory disease risks

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis

Differences in the Microbial Composition of Hemodialysis Patients Treated With and Without β-Blockers

Contact Info

Product

Resources

About