Consumption of Nonfat Milk Results in a Less Atherogenic Lipoprotein Profile: A Pilot Study

Hidaka, Hiroya; Takiwaki, Masaki; Yamashita, Mine; Kawasaki, Kenji; Sugano, Mitsutoshi; Honda, Takayuki

doi:10.1159/000339261

Cited by 18 publications

(14 citation statements)

References 26 publications

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“…Similar conclusions were drawn from a small crossover RCT comprising 8 healthy men in whom consumption of whole-fat milk or skimmed milk for 6 wk had no impact on fasting TG concentrations (23). On the other hand, consumption of skimmed milk (500 mL/d) for 2 wk was shown to reduce fasting TG concentrations compared with whole-milk consumption in 14 normolipidemic subjects (34). …”

Section: Dairy and Cardiometabolic Disease Risk Factorsmentioning

confidence: 99%

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Comprehensive Review of the Impact of Dairy Foods and Dairy Fat on Cardiometabolic Risk

Drouin‐Chartier¹,

Côté

Labonté

et al. 2016

Advances in Nutrition

120

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Because regular-fat dairy products are a major source of cholesterol-raising saturated fatty acids (SFAs), current US and Canadian dietary guidelines for cardiovascular health recommend the consumption of low-fat dairy products. Yet, numerous randomized controlled trials (RCTs) have reported rather mixed effects of reduced- and regular-fat dairy consumption on blood lipid concentrations and on many other cardiometabolic disease risk factors, such as blood pressure and inflammation markers. Thus, the focus on low-fat dairy in current dietary guidelines is being challenged, creating confusion within health professional circles and the public. This narrative review provides perspective on the research pertaining to the impact of dairy consumption and dairy fat on traditional and emerging cardiometabolic disease risk factors. This comprehensive assessment of evidence from RCTs suggests that there is no apparent risk of potential harmful effects of dairy consumption, irrespective of the content of dairy fat, on a large array of cardiometabolic variables, including lipid-related risk factors, blood pressure, inflammation, insulin resistance, and vascular function. This suggests that the purported detrimental effects of SFAs on cardiometabolic health may in fact be nullified when they are consumed as part of complex food matrices such as those in cheese and other dairy foods. Thus, the focus on low-fat dairy products in current guidelines apparently is not entirely supported by the existing literature and may need to be revisited on the basis of this evidence. Future studies addressing key research gaps in this area will be extremely informative to better appreciate the impact of dairy food matrices, as well as dairy fat specifically, on cardiometabolic health.

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Section: Dairy and Cardiometabolic Disease Risk Factorsmentioning

confidence: 99%

“…Consuming nonfat milk (500 mL/d) for 2 wk was shown to increase LDL size in a small group of 14 healthy normolipidemic Japanese subjects (34). …”

Section: Dairy and Cardiometabolic Disease Risk Factorsmentioning

confidence: 99%

Comprehensive Review of the Impact of Dairy Foods and Dairy Fat on Cardiometabolic Risk

Drouin‐Chartier¹,

Côté

Labonté

et al. 2016

Advances in Nutrition

120

View full text Add to dashboard Cite

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“…7, 9, 10, 11, 12, 13, 14 These include: an association with reduced body mass index (BMI) and waist circumference; 10 improvement of blood lipid profiles; 11, 12, 13 reduced risk of hypertension; 14 improvement of glycaemic responses 15 and reduced risk of type 2 diabetes. 16, 17 However, conflictions exist in the current literature, with a number of reports observing no association with dairy intake and various markers of metabolic health.…”

Section: Introductionmentioning

confidence: 99%

Patterns of dairy food intake, body composition and markers of metabolic health in Ireland: results from the National Adult Nutrition Survey

et al. 2017

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Background:Studies examining the association between dairy consumption and metabolic health have shown mixed results. This may be due, in part, to the use of different definitions of dairy, and to single types of dairy foods examined in isolation.Objective:The objective of the study was to examine associations between dairy food intake and metabolic health, identify patterns of dairy food consumption and determine whether dairy dietary patterns are associated with outcomes of metabolic health, in a cross-sectional survey.Design:A 4-day food diary was used to assess food and beverage consumption, including dairy (defined as milk, cheese, yogurt, cream and butter) in free-living, healthy Irish adults aged 18–90 years (n=1500). Fasting blood samples (n=897) were collected, and anthropometric measurements taken. Differences in metabolic health markers across patterns and tertiles of dairy consumption were tested via analysis of covariance. Patterns of dairy food consumption, of different fat contents, were identified using cluster analysis.Results:Higher (total) dairy was associated with lower body mass index, %body fat, waist circumference and waist-to-hip ratio (P<0.001), and lower systolic (P=0.02) and diastolic (P<0.001) blood pressure. Similar trends were observed when milk and yogurt intakes were considered separately. Higher cheese consumption was associated with higher C-peptide (P<0.001). Dietary pattern analysis identified three patterns (clusters) of dairy consumption; 'Whole milk', 'Reduced fat milks and yogurt' and 'Butter and cream'. The 'Reduced fat milks and yogurt' cluster had the highest scores on a Healthy Eating Index, and lower-fat and saturated fat intakes, but greater triglyceride levels (P=0.028) and total cholesterol (P=0.015). conclusion: Overall, these results suggest that while milk and yogurt consumption is associated with a favourable body phenotype, the blood lipid profiles are less favourable when eaten as part of a low-fat high-carbohydrate dietary pattern. More research is needed to better understand this association.Conclusion:Overall, these results suggest that although milk and yogurt consumption is associated with a favourable body phenotype, the blood lipid profiles are less favourable when eaten as part of a low-fat high-carbohydrate dietary pattern. More research is needed to better understand this association.

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“…Meta-analyses of cohort studies have also shown that milk intake was associated with a reduced risk of hypertension [ 14 , 15 ], but not with type 2 diabetes risk [ 16 – 18 ]. On the other hand, data from randomized clinical trials having assessed the impact of milk consumption on cardiometabolic risk factors are mixed and not fully consistent with data from epidemiological studies [ 19 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity

Drouin‐Chartier

Gagnon

Labonté

et al. 2015

Nutr J

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BackgroundThe impact of dairy intake on cardiometabolic risk factors associated with metabolic syndrome (MetS) needs further research.ObjectiveTo investigate the impact of milk consumption on a wide array of cardiometabolic risk factors associated with MetS (blood lipids, cholesterol homeostasis, glucose homeostasis, systemic inflammation, blood pressure, endothelial function) in postmenopausal women with abdominal obesity.MethodsIn this randomized, crossover study, 27 women with abdominal obesity consumed two 6-week diets based on the National Cholesterol Education Program (NCEP), one with 3.2 servings/d of 2% fat milk per 2000 kcal (MILK) and one without milk or other dairy (NCEP). The macronutrient composition of both diets was comparable (55% carbohydrates, 15% proteins, 30% fat and 10% saturated fat).ResultsThe MILK diet had no significant effect on LDL-C, triglycerides, LDL size, CRP and cell adhesion molecule concentrations and on indicators of insulin sensitivity. The MILK diet reduced HDL-C, adiponectin, endothelin and fasting glucose levels as well blood pressure (all P ≤ 0.01), but those changes were comparable to those seen with the NCEP milk-free diet (all between-diet P ≥ 0.07). Finally, the MILK diet was associated with lower VLDL apolipoprotein B fractional catabolic rate (−13.4%; P = 0.04) and plasma sterol concentrations (−12.0%; P = 0.04) compared with the control NCEP milk-free diet.ConclusionsThese data suggest that short-term consumption of low fat milk in the context of a prudent NCEP diet has no favorable nor deleterious effect on cardiometabolic risk factors associated with MetS in postmenopausal women with abdominal obesity.Electronic supplementary materialThe online version of this article (doi:10.1186/1475-2891-14-12) contains supplementary material, which is available to authorized users.

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Consumption of Nonfat Milk Results in a Less Atherogenic Lipoprotein Profile: A Pilot Study

Cited by 18 publications

References 26 publications

Comprehensive Review of the Impact of Dairy Foods and Dairy Fat on Cardiometabolic Risk

Comprehensive Review of the Impact of Dairy Foods and Dairy Fat on Cardiometabolic Risk

Patterns of dairy food intake, body composition and markers of metabolic health in Ireland: results from the National Adult Nutrition Survey

Impact of milk consumption on cardiometabolic risk in postmenopausal women with abdominal obesity

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