Consumption of Stilbenes and Flavonoids is Linked to Reduced Risk of Obesity Independently of Fiber Intake

Mompeó, Olatz; Spector, Tim D.; Matey-Hernandez, María Luisa; Roy, Caroline; Istas, Geoffrey; Sayec, Melanie Le; Mangino, Massimo; Jennings, Amy; Rodriguez-Mateos, Ana; Valdes, Ana M.; Menni, Cristina

doi:10.3390/nu12061871

Cited by 23 publications

(20 citation statements)

References 53 publications

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“…On the other hand, it may be due to the presence of compounds common in vegetables but not in fruits. This would exclude plant-based food components such as dietary fibre or polyphenols, which are found both in fruit and vegetables [44] and tend to be higher in fruits. We hypothesised that it could be dietary nitrate content, which has been related to improved cardiometabolic outcomes [45], increased nitric oxide production and altered inflammation and immune function [18].…”

Section: Discussionmentioning

confidence: 99%

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome

Menni

Louca

Berry

et al. 2021

BMC Med

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Background Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19. Methods Here, we assessed the association between white blood cell profile (lymphocytes, basophils, eosinophils, neutrophils, monocytes and total white blood cells) as markers of chronic inflammation, habitual diet and gut microbiome composition (determined by sequencing of the 16S RNA) in 986 healthy individuals from the PREDICT-1 nutritional intervention study. We then investigated whether the gut microbiome mediates part of the benefits of vegetable intake on lymphocyte counts. Results Higher levels of white blood cells, lymphocytes and basophils were all significantly correlated with lower habitual intake of vegetables, with vegetable intake explaining between 3.59 and 6.58% of variation in white blood cells after adjusting for covariates and multiple testing using false discovery rate (q < 0.1). No such association was seen with fruit intake. A mediation analysis found that 20.00% of the effect of vegetable intake on lymphocyte counts was mediated by one bacterial genus, Collinsella, known to increase with the intake of processed foods and previously associated with fatty liver disease. We further correlated white blood cells to other inflammatory markers including IL6 and GlycA, fasting and post-prandial glucose levels and found a significant relationship between inflammation and diet. Conclusion A habitual diet high in vegetables, but not fruits, is linked to a lower inflammatory profile for white blood cells, and a fifth of the effect is mediated by the genus Collinsella. Trial registration The ClinicalTrials.gov registration identifier is NCT03479866.

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Section: Discussionmentioning

confidence: 99%

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome

Menni

Louca

Berry

et al. 2021

BMC Med

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“…In addition, Lachnospira was negatively correlated with PRT, NA, FE, VD, VB6, and VB12 intake ( rs = −0.38, −0.41, −0.39, −0.63, −0.42, −0.49, respectively). A previous study demonstrated that the relative abundance of Lachnospira was positively associated with vegetable intake [ 53 ], and that Lachnospira had a positive correlation with stilbene in an observational study [ 54 ]. Ingestion of a high-fat diet (HFD) induces oxidative stress and microbial dysbiosis, the latter playing an important role in the development of metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Nutrient Intake and Human Gut Microbiota in Monozygotic Twins

et al. 2021

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Background and Objectives: The gut microbiota is associated with human health and dietary nutrition. Various studies have been reported in this regard, but it is difficult to clearly analyze human gut microbiota as individual differences are significant. The causes of these individual differences in intestinal microflora are genetic and/or environmental. In this study, we focused on differences between identical twins in Japan to clarify the effects of nutrients consumed on the entire gut microbiome, while excluding genetic differences. Materials and Methods: We selected healthy Japanese monozygotic twins for the study and confirmed their zygosity by matching 15 short tandem repeat loci. Their fecal samples were subjected to 16S rRNA sequencing and bioinformatics analyses to identify and compare the fluctuations in intestinal bacteria. Results: We identified 12 genera sensitive to environmental factors, and found that Lactobacillus was relatively unaffected by environmental factors. Moreover, we identified protein, fat, and some nutrient intake that can affect 12 genera, which have been identified to be more sensitive to environmental factors. Among the 12 genera, Bacteroides had a positive correlation with retinol equivalent intake (rs = 0.38), Lachnospira had a significantly negative correlation with protein, sodium, iron, vitamin D, vitamin B6, and vitamin B12 intake (rs = −0.38, −0.41, −0.39, −0.63, −0.42, −0.49, respectively), Lachnospiraceae ND3007 group had a positive correlation with fat intake (rs = 0.39), and Lachnospiraceae UCG-008 group had a negative correlation with the saturated fatty acid intake (rs = −0.45). Conclusions: Our study is the first to focus on the relationship between human gut microbiota and nutrient intake using samples from Japanese twins to exclude the effects of genetic factors. These findings will broaden our understanding of the more intuitive relationship between nutrient intake and the gut microbiota and can be a useful basis for finding useful biomarkers that contribute to human health.

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“…In a coculture of adipocyte and macrophage system, piceatannol significantly reduced the release of TNF-α and monocyte chemoattractant protein-1 (MCP-1) [ 111 ]. Stilbene, flavonoid and total (poly)phenol intake was associated with higher gut microbiome diversity, an increase in butyrate producing organisms and 20–23% lower prevalence of obesity [ 112 ].…”

Section: Herbal and Dietary Supplementation For Weight Managementmentioning

confidence: 99%

“…Nutrients 2021, 13, x FOR PEER REVIEW 12 of 24 release of TNF-α and monocyte chemoattractant protein-1 (MCP-1) [111]. Stilbene, flavonoid and total (poly)phenol intake was associated with higher gut microbiome diversity, an increase in butyrate producing organisms and 20%-23% lower prevalence of obesity [112]. Mechanism of action: Piceatannol inhibits adipogenesis by inhibiting mitotic clonal expansion and lowering the protein levels of adipogenic transcription factors such as PPARγ and C/EBPα in 3T3-L1 cells in vitro.…”

Section: Curcuma Longamentioning

confidence: 99%

Lesser Investigated Natural Ingredients for the Management of Obesity

Majeed

Nagabhushanam

et al. 2021

Nutrients

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Obesity, an epidemiological disorder, is related to various complications in both the developed and developing world. It epitomizes a crucial risk factor for health, decreasing productivity and life expectancy while increasing health care costs worldwide. Conventional therapies with synthetic drugs or bariatric surgery, associated with numerous side effects, recurrence, and surgical complexity, have been restricted in their use. Lifestyle changes and dietary restrictions are the proven methods for successful weight loss, although maintaining a strict lifestyle is a challenge. Multiple natural products have been explored for weight management with varied efficacy. The current review explores less explored natural herbs, their active constituents, and their mechanisms of action against obesity.

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Consumption of Stilbenes and Flavonoids is Linked to Reduced Risk of Obesity Independently of Fiber Intake

Cited by 23 publications

References 53 publications

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome

Relationship between Nutrient Intake and Human Gut Microbiota in Monozygotic Twins

Lesser Investigated Natural Ingredients for the Management of Obesity

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