Contact Allergy from Vitamins in Cosmetic Products

Santos, Aquilina Ramírez; Fernández‐Redondo, Virginia; Pérez, L. Pérez; Cao, Javier Concheiro; Toribio, Jaime

doi:10.2310/6620.2008.07005

Cited by 13 publications

(12 citation statements)

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“…Numerous case reports were presented in the original CIR report on tocopherol-containing products, and additional reports have been published since the original CIR report was issued ( Table 7). [69][70][71][72][73]…”

Section: Contact Allergy: Case Reportsmentioning

confidence: 99%

Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics

Fiume¹,

Bergfeld²,

Belsito³

et al. 2018

Int J Toxicol

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The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 14 tocopherols and tocotrienols and concluded these ingredients are safe as used in cosmetics. The tocopherols are reported to function in cosmetics as antioxidants or skinconditioning agents; in contrast, tocotrienols are not reported to function as an antioxidants in cosmetics but as a light stabilizer, oral care agent, or skin-conditioning agent. The Panel reviewed the new and existing animal and clinical data to determine the safety of these ingredients and found it appropriate to extrapolate the existing information to conclude on the safety of all the tocopherols and tocotrienols.

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Section: Contact Allergy: Case Reportsmentioning

confidence: 99%

Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics

Fiume¹,

Bergfeld²,

Belsito³

et al. 2018

Int J Toxicol

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“…The cosmetic use of vitamins has increased because they are considered to be natural components. 3 Vitamin E is contained in many cosmetic products because of its antioxidant and anti-ageing properties. Tocopherol (CAS no.…”

Section: Discussionmentioning

confidence: 99%

“…10191-41-0 for DL-tocopherol) is a rare cause of contact dermatitis and an exceptional cause of contact urticaria. [2][3][4] Reviewing the literature, we found only Contact urticaria caused by cosmetics produces a broad spectrum of clinical manifestations; these are usually limited to contact areas, but generalized urticaria with or without extracutaneous manifestations that can be exceptionally life-threatening have been reported. 7…”

Section: Discussionmentioning

confidence: 99%

Contact urticaria caused by tocopherol

et al. 2018

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K E Y W O R D S : allergic contact dermatitis, CAS no. 10191-41-0, case report, contact urticaria, cosmetics, tocopherol Contact urticaria can be caused by cosmetic products, for instance by dyes, preservatives, fragrances, sunscreens and ingredients derived from plants and animals. 1 Vitamin E may be found in many cosmetic products as tocopherol or as its esterified form, tocopheryl. Side effects from the use of tocopherol are uncommon, despite widespread use. 2 We report a case of contact urticaria after the use of a cosmetic product containing tocopherol. CASE REPORTA healthy 11-year-old girl was referred for investigation of an episode of pruritus and facial oedema minutes after applying a cleansing water.Neither respiratory nor mucosal symptoms or lesions were reported.The patient's past history was unremarkable. An open test on the forearm with cleansing water "as is" gave a positive result after 30 minutes, with the appearance of a 28 × 15-mm wheal reaction that disappeared within <24 hours; no other lesions were observed until 96 hours later.Five control subjects showed no reactions in this open test. The components of this cosmetic product that were included in fragrance and cosmetic series from Chemotechnique Diagnostics (Vellinge, Sweden) were tested in duplicate by open application on both forearms. We only observed a wheal with tocopherol 10% pet. after 30 minutes, which resolved within 24 hours on both forearms. The other ingredients studied, namely, phenoxyethanol, hexyl cinnamal, benzyl salicylate and linalool, gave negative results. We could not perform further tests with all of the other ingredients, because they were not supplied by the manufacturer. The patient has not suffered from recurrences after avoiding products containing vitamin E. DISCUSSIONFragrances and preservatives are the most common cosmetic allergens, but the pattern of sensitivity to ingredients keeps changing, because the composition of the products is continually changing. The cosmetic use of vitamins has increased because they are considered to be natural components. 3 Vitamin E is contained in many cosmetic products because of its antioxidant and anti-ageing properties. Tocopherol (CAS no. 10191-41-0 for DL-tocopherol) is a rare cause of contact dermatitis and an exceptional cause of contact urticaria. 2-4 Reviewing the literature, we found only 1 case of contact urticaria, reported in 1991 by de Groot et al, who described erythema and urticarial papules on the face and neck with oedema of the eyelids after the first-time use of a face cream containing tocopheryl acetate, and another article on contact urticaria caused by a vitamin E preparation in 2 siblings in 1974 by Kasssen et al. 2,4 The majority of cases of contact dermatitis are local reactions, although some cases have been reported of widespread lesions despite local application. 5,6 De Groot et al recommended tocopherol 10% pet. as a test concentration. 4Contact urticaria caused by cosmetics produces a broad spectrum of clinical manifestations; these are usually ...

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“…The synthetic form, DL-tocopherol is a mixture of eight stereoisomers, and the esterified forms (usually the acetate ester) are more stable, although their antioxidant potential is minimal [1]. Furthermore, the DL-form of vitamin E has been reported to cause allergic contact dermatitis when applied topically [2][3][4][5][6][7][8][9], and only tocopherol causes an erythema-multiforme-like eruption [4]. Our patient showed no allergic reaction to DL-alpha-tocopheryl acetate 0.5%, which was an ingredient of the cream she was using.…”

Section: Discussionmentioning

confidence: 99%

Allergic Contact Dermatitis Syndrome Due to Tocopherol Acetate, in Addition to Glycyrrhetinic Acid

Ohko

Ito²,

Ito³

2012

JCDSA

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Natural vitamin E is suggested to have an antioxidant function. However, the synthetic form of vitamin E, DL-tocopherol, which has been widely used in topical ointments, may cause allergic contact dermatitis. Here, we report a case of allergic contact dermatitis with erythema multiforme-like eruption caused by a topical ointment. Patch testing indicated a positive allergic reaction to an anti-inflammatory ointment the patient had been using and its ingredient, DL-alpha-tocopheryl acetate (vitamin E). In addition, a positive reaction to glycyrrhetinic acid was observed. Both vitamin E and glycyrrhetinic acid are useful ingredients of topical applications. However, the possibility that both can cause contact dermatitis, albeit rarely, should be considered

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Contact Allergy from Vitamins in Cosmetic Products

Cited by 13 publications

References 0 publications

Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics

Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics

Contact urticaria caused by tocopherol

Allergic Contact Dermatitis Syndrome Due to Tocopherol Acetate, in Addition to Glycyrrhetinic Acid

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