Contact Allergy Induced by Mango (Mangifera indica): A Relevant Topic?

Abstract

Introduction: The most common clinical manifestation of mango allergy is contact dermatitis, which can be localized or systemic. The sensitising substances that have long been suspected are alk(en)yl catechols and/or alk(en)yl resorcinols. Methods: We reviewed the original articles published on Pubmed, Embase and Cochrane Library before 15 September 2021, on the topic of contact allergy induced by mango and we synthesized the key data. Results: We found 12 case reports and four case series, with a total of 37 patients. Only seven of these cases were reported in patients from mango-cultivating countries, the other 30 were from countries where mango cultivation does not occur, and 26 were also from countries where poison ivy/oak are commonly found. We found that contact dermatitis may occur on the first exposure to mango due to previous sensitisation to urushiol-containing plants. The diagnosis was confirmed by patch testing in some of the cases. There was great heterogeneity between the reagents used. Conclusion: Mango fruit is frequently consumed, but mango induced contact dermatitis, the main hypersensitivity reaction induced by mango, is rare. Further data is necessary for a better understanding of sensitising substances and, consecutively, standardization of patch test reagents.

Bioactive Compounds and Antioxidant Activities in Different Fractions of Mango Fruits (Mangifera indica L., Cultivar Tommy Atkins and Keitt)

“…Although rare cases of mango pulp-induced allergic contact dermatitis have been reported, a spectrum of hypersensitivity reactions has been associated to direct contact with peels particularly rich in these compounds, especially in subjects previously exposed to the urushiol containing plants, e.g., poison ivy (Toxicodendron radicans (L.) Kuntze) and poison oak (T. diversilobum (Torr. & A.Gray) Greene) [95,96]. Hence, the exploitation of mango peels must take into account the presence of these sensitizing substances in order to select an appropriate extraction method for obtaining a product free from potential allergens.…”

A comprehensive review on mango allergy: Clinical relevance, causative allergens, cross‐reactivity, influence of processing techniques, and management strategies

“…Upon direct contact with the antigen present in mango fruit or the bark of the mango tree, an individual experiences a localized inflammatory response. Symptoms usually manifest within 8–12 h after exposure and encompass the formation of a rash and induration, eventually progressing to blister formation within 72 h (Berghea et al., 2021). After initial contact, macrophages present the antigen to Th cells.…”

“…Mango-related immediate hypersensitivity reactions might take the form of either a local or systemic allergic reaction. Rashes, itching, hives, eczema, erythema, and angioedema are examples of skin symptoms (Berghea et al, 2021;Kashyap & Kashyap, 2015;Paola et al, 2014). Wheezing, nasal congestion, breathing difficulties, pain Life-threatening anaphylaxis Shortness of breath, heart rate increase, blood pressure decreases, anaphylactic shock, dizziness, fainting, or less of consciousness Ho et al (2014) in the abdomen, nausea, and vomiting are more prominent systemic symptoms (Sharma et al, 2015).…”

“…It belongs to the Anacardiaceae family. Known for its abundant macro‐ and micronutrients and bioactive components, mango fruit is often dubbed the “king of fruit” or “fruit of the gods” (Berghea et al., 2021). In fact, it ranks as the fifth most commonly consumed fruit worldwide.…”

Chemical and cytotoxicity profiles of 11 pink pepper (Schinus spp.) samples via non-targeted hyphenated high-performance thin-layer chromatography

“…In the 1980s, the toxicity or allergenic potential of pink pepper was brought to light, and the product was banned for sale in the United States of America by the Food and Drug Administration for a few years (Burros, 1982 ). Reports of severe anaphylactic reactions still happened after the ban was lifted, but the common hypothesis for these events was that allergic reactions occur predominantly due to cross-reactions in people that are allergic to other Anacardiaceae species such as cashew, pistachios, and mangos (Berghea et al, 2021 ; Fong et al, 2019 ). Some level of toxicity might also happen from previous sensitization with for example poison ivy or poison oak ( Toxicodendron spp.…”