Contact Allergy Towards Ninhydrin in a Marking Pen for Patch Testing

Allergenic and microbiological hazards caused by skin markings during medical procedures?

“…Current data analysis of the IVDK group shows that, despite their frequent use, contact allergies to skin markers are rare. This is consistent with the published literature, which only includes isolated cases of contact allergies to medical skin markers [ 1,2,[9][10][11][12] and nonmedical text markers (offi ce supply) [3][4][5][6][7][8][13][14][15][16][17] .…”

“…In 149 of these 453 patients (32.9 %), the patients' own materials were tested; (marker) pens were tested in three patients (total of eight patch tests; 0.0047 % of the entire collective) and were negative in each case. A PubMed literature search from 1953 to 2/2016 yielded 21 cases of allergic contact dermatitis caused by skin markers [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] , with different substances in the various products identifi ed as triggers (Table 1 ). These publications were case reports and not Abbr.…”

Rhinitis caused by ninhydrin develops into occupational asthma

“…Ninhydrin can cause skin irritation, and has already been shown to cause type IV allergic eczema [2,3]. An increasing number of other "contact allergens" have now been shown to induce type I allergic reactions, verified with specific IgE measurements or specific challenge tests, such as nickel [13,14], acrylates [15] and epoxy resin [16].…”

“…It is, therefore, used in chromatography for extracting allergens [1], as a dye in marking the skin for surgery and dermatology, and in fingerprint detection in forensic laboratories. A few cases of allergic contact eczema caused by ninhydrin have been reported [2,3].…”