Contact Angle Measurement on Medical Implant Titanium Based Biomaterials

Strnad, Gabriela; Chirilă, Nicolae; Petrovan, Cecilia; Russu, Octav

doi:10.1016/j.protcy.2016.01.094

Cited by 50 publications

(27 citation statements)

References 9 publications

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“…We have shown in our previous study similar contact angle values 80–100° obtained for unpolished rough selective laser melted titanium fabricated with energy densities as high as 150 J/mm 3 [ 49 ]. The contact angle of fabricated discs was at least tens of degrees higher than for titanium alloys fabricated conventionally [ 46 , 50 , 51 ]. Minimizing the contact angle and maximizing the surface energy is recognized as beneficial for obtaining biomaterials that promote cell response [ 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Selective Laser Melting (SLM) Process Parameters on In-Vitro Cell Response

Wysocki

Idaszek

Zdunek

et al. 2018

IJMS

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The use of laser 3D printers is very perspective in the fabrication of solid and porous implants made of various polymers, metals, and its alloys. The Selective Laser Melting (SLM) process, in which consolidated powders are fully melted on each layer, gives the possibility of fabrication personalized implants based on the Computer Aid Design (CAD) model. During SLM fabrication on a 3D printer, depending on the system applied, there is a possibility for setting the amount of energy density (J/mm3) transferred to the consolidated powders, thus controlling its porosity, contact angle and roughness. In this study, we have controlled energy density in a range 8–45 J/mm3 delivered to titanium powder by setting various levels of laser power (25–45 W), exposure time (20–80 µs) and distance between exposure points (20–60 µm). The growing energy density within studied range increased from 63 to 90% and decreased from 31 to 13 µm samples density and Ra parameter, respectively. The surface energy 55–466 mN/m was achieved with contact angles in range 72–128° and 53–105° for water and formamide, respectively. The human mesenchymal stem cells (hMSCs) adhesion after 4 h decreased with increasing energy density delivered during processing within each parameter group. The differences in cells proliferation were clearly seen after a 7-day incubation. We have observed that proliferation was decreasing with increasing density of energy delivered to the samples. This phenomenon was explained by chemical composition of oxide layers affecting surface energy and internal stresses. We have noticed that TiO2, which is the main oxide of raw titanium powder, disintegrated during selective laser melting process and oxygen was transferred into metallic titanium. The typical for 3D printed parts post-processing methods such as chemical polishing in hydrofluoric (HF) or hydrofluoric/nitric (HF/HNO3) acid solutions and thermal treatments were used to restore surface chemistry of raw powders and improve surface.

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Section: Discussionmentioning

confidence: 99%

The Influence of Selective Laser Melting (SLM) Process Parameters on In-Vitro Cell Response

Wysocki

Idaszek

Zdunek

et al. 2018

IJMS

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“…In order to predict the implant wettability under physiological conditions, SBF was used instead of DI H 2 O during contact angle goniometry (Tan et al, 2012b). Both Ti and PS surfaces are considered hydrophilic, as they have water contact angles are <90° (Zeiger et al, 2013; Strnad et al, 2016). Coating these implants with ECM proteins seems to enhance their hydrophilicity, with a greater effect seen in the plasma-facilitated coatings (from 65° to 25°) (Figure 3A).…”

Section: Resultsmentioning

confidence: 99%

Customizable Implant-specific and Tissue-Specific Extracellular Matrix Protein Coatings Fabricated Using Atmospheric Plasma

Tan

Al‐Rubeai

2019

Front. Bioeng. Biotechnol.

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Progression in implant science has benefited from ample amount of technological contributions from various disciplines, including surface biotechnology. In this work, we successfully used atmospheric plasma to enhance the biological functions of surgical implants by coating them with extracellular matrix proteins. The developed collagen and laminin coatings demonstrate advantageous material properties. Chemical analysis by XPS and morphological investigation by SEM both suggested a robust coating. Contact angle goniometry and dissolution study in simulated body fluid (SBF) elicited increased hydrophilicity and physiological durability. Furthermore, these coatings exhibited improved biological interactions with human mesenchymal and neural stem cells (NSCs). Cell adhesion, proliferation, and differentiation proved markedly refined as shown by enzymatic detachment, flow cytometry, and ELISA data, respectively. Most importantly, using the pathway-specific PCR array, our study discovered dozens of deregulated genes during osteogenesis and neurogenesis on our newly fabricated ECM coatings. The coating-induced change in molecular profile serves as a promising clue for designing future implant-based therapy. Collectively, we present atmospheric plasma as a versatile tool for enhancing surgical implants, through customizable implant-specific and tissue-specific coatings.

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“…This behavior is influenced by the surface topography of sample, which determines its hydrophilic or hydrophobic nature. For implant materials, a hydrophilic surface is considered to be desirable in view of its better interaction with biological fluids, cells and tissues [29,30]. Figure 3 presents the X-ray diffractograms: (a) Ti-35Nb_Control, and (b) Ti-35Nb_4h.…”

Section: Contact Angle Measurementmentioning

confidence: 99%

Characterization of Ti-35Nb alloy surface modified by controlled chemical oxidation for surgical implant applications

Silva

Ribeiro

2019

Matéria (Rio J.)

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Titanium-Niobium alloys have been studied for biomedical applications due to their satisfactory biocompatibility. In order to improve the long-term implantation, surface modification techniques have been developed to generate suitable topography, roughness, chemical composition, surface energy, etc. Considering this approach, the present work aimed to characterize Titanium-35Niobium (Ti-35Nb) surface modified by controlled chemical oxidation. Ti-35Nb (wt%) substrates were processed by powder metallurgy. The powders were mechanically mixed, uniaxially cold pressed and sintering at 1300ºC/2h. Then, the sintered substrates were immersed in a solution consisting of equal volumes of concentrated H 2 SO 4 and 30% aqueous H 2 O 2 for 4 hours at room temperature under continuous agitation. Sample characterizations were performed by scanning electron microscopy, profilometry, contact angle measurement, X-ray diffraction, and X-ray photoelectron spectroscopy. The results showed that the samples exhibited a microporous structure with micro-roughness on surface, and the β-Ti phase was stabilized by complete niobium atoms diffusion in titanium matrix. In addition, the chemical treatment successfully modified the Ti-35Nb surface with micropore formation and enhancement of hydrophilic feature and TiO 2 and Nb 2 O 5 layer, which can improve the biocompatibility of TiNb alloy implants.

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Contact Angle Measurement on Medical Implant Titanium Based Biomaterials

Cited by 50 publications

References 9 publications

The Influence of Selective Laser Melting (SLM) Process Parameters on In-Vitro Cell Response

The Influence of Selective Laser Melting (SLM) Process Parameters on In-Vitro Cell Response

Customizable Implant-specific and Tissue-Specific Extracellular Matrix Protein Coatings Fabricated Using Atmospheric Plasma

Characterization of Ti-35Nb alloy surface modified by controlled chemical oxidation for surgical implant applications

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