Contact dermatitis due to chlorpheniramine maleate in eyedrops

Abstract

heptyl-a-methylene-y-butyro-lactones and camphene. Can J Biochem 1978: 56: 153-157. 16. Schlewer G, Stampf J L, Benezra C. Synthesis of a-methylene-y-butyrolactones: a structure-ac-Contact Dermatitis 1990: 22: 55 tivity relationship study of their allergenic power.

Case of allergic contact dermatitis due to a topical agent containing chlorpheniramine maleate, with a false‐negative patch test

“…Several cases of allergic contact dermatitis due to chlorpheniramine maleate have been reported 1–4 . Many over‐the‐counter topical medications containing chlorpheniramine maleate are sold in some countries, which may increase the risk of sensitization.…”

Cutaneous adverse drug reaction to oral chlorphenamine detected with patch testing

“…It can be administered by topical, oral and intravenous routes. Topical use is thought to be responsible for sensitization and subsequent contact allergy (2) and allergic contact dermatitis (ACD) from chlorphenamine cream (3) and in eye drops for chronic conjunctivitis (4) has been reported.…”

Adverse Cutaneous Reactions of Systemic Antihistamines

“…These are not commonly used as topical agents, however, a patient was reported with facial contact dermatitis induced by a topical eye drop containing both cromolyn and chlorpheniramine [38]. Patch testing with chlorpheniramine at 5% in petrolatum was positive.…”