Cutaneous adverse drug reaction to oral chlorphenamine detected with patch testing

Allergic contact dermatitis from dibucaine hydrochloride, chlorpheniramine maleate, and naphazoline hydrochloride in an over‐the‐counter topical antiseptic

“…Chlorpheniramine maleate is an antihistamine that is orally and intravenously administrated and topically applied (3). Topical application is believed to be responsible for the sensitization (5). Naphazoline hydrochloride stimulates the peripheral alpha‐2 adrenergic receptors and acts as a vasoconstrictor.…”

Place of Drug Skin Tests in Investigating Systemic Cutaneous Drug Reactions

“…Miscellaneous drugs have been reported as yielding CADR with positive drug patch tests [2,4,31] : acyclovir and valacyclovir [21,83] , allylisopropylacetylurea in a FDE [84] , captopril at 1 and 10% in petrolatum [2,85] , cefcapene pivoxil [86] , celecoxib [12,87] , clindamycin [31] , clobazam [88] , chlorphenamine (20% in petrolatum) [89] , codeine diluted at 1 and 5% in petrolatum (2 negative controls) [90] , cotrimoxazole [22,25] , cyamemazine [23] , diazepam [3,52] , diclofenac [28,91] , enoxoparin [2,3] , estrogens [20] , fluindione [92] , fluoroquinolones [2,3,[93][94][95] , fusafungine [2] , gentamycin [31] , isoniazide at 50% in petrolatum (10 negative controls) [31,96] , Lamisil [2,3] , meprobamate [2,3] , metamizole at 1 and 10% in petrolatum [97,98] , metronidazole [31] , mexiletine hydrochloride diluted at 10 and 20% in petrolatum [99] , minocyclin [100] , nimesulide …”