Allergic contact dermatitis from dibucaine hydrochloride, chlorpheniramine maleate, and naphazoline hydrochloride in an over‐the‐counter topical antiseptic

Yamadori, Yoshika; Oiso, Naoki; Hirao, Ayaka; Kawara, Shigeru; Kawada, Akira

doi:10.1111/j.1600-0536.2009.01556.x

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Current Issues In Pharmacy and Medical Sciences1

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Cited by 10 publications

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“…Only 1 vasoconstricting eye drop in our study contained thimerosal, allergy to which would be relevant in a sensitized individual 5 . Active ingredients, such as naphazoline, may also cause allergy 6 …”

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confidence: 84%

Contact Allergens in Over-the-Counter Topical Vasoconstricting Ophthalmic Agents

2021

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confidence: 84%

Contact Allergens in Over-the-Counter Topical Vasoconstricting Ophthalmic Agents

2021

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“…Signs of local toxic effects of drugs containing naphazoline include rash, flushing and itching [16]. In contact with the skin, the drug at a concentration of 1% brings about allergic reactions, as confirmed by the prick test [8,48]. What is more, the potential was demonstrated of naphazoline capacity to act as a photosensitiser [40].…”

Section: Current Issues In Pharmacy and Medical Sciencesmentioning

confidence: 99%

Rationale for naphazoline effects in-depth study

Kuzminov

Turkina

Кuzminov

2018

Current Issues in Pharmacy and Medical Sciences

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This article presents a retrospective review of data on side effects of drugs containing naphazoline and data on toxicity of the agent when entered the body via different pathways. Most publications on clinical signs of possible naphazoline-associated side effects are lacking thorough analysis of possible causes. Limited data on the pharmacokinetics and pharmacodynamics of the drug led to various complications after its administration. Therefore, further studies on naphazoline content dynamics or products of its biotransformation in biological substrates and determination of half-life of the agent must be conducted. This will allow establishingsafe levels for different exposure pathways and harmful levels of the naphazoline with respect to its material accumulation. It should be noted that scientific publications contain controversial data regarding allergenic potential of the agent. Possible side effects of the drug on the reproductionand development are not revealed. Determination of effects the products containing naphazoline may have on immune and reproductive system is an important part of the research.

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Contact Allergy to Topical Drugs

Goossens¹,

Gonçalo²

2020

Contact Dermatitis

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Allergic contact dermatitis from dibucaine hydrochloride, chlorpheniramine maleate, and naphazoline hydrochloride in an over‐the‐counter topical antiseptic

Cited by 10 publications

References 5 publications

Contact Allergens in Over-the-Counter Topical Vasoconstricting Ophthalmic Agents

Contact Allergens in Over-the-Counter Topical Vasoconstricting Ophthalmic Agents

Rationale for naphazoline effects in-depth study

Contact Allergy to Topical Drugs

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