Contact dermatitis to α‐lipoic acid in an anti‐wrinkle cream

Bergqvist-Karlsson, A; Thelin, Ingrid; Bergendorff, Ola

doi:10.1111/j.0105-1873.2006.0847c.x

Cited by 16 publications

(17 citation statements)

References 3 publications

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“…Thus, application every other day for the first few weeks may help improve tolerance. Contact dermatitis has also been reported (39). N.V. Perricone M.D.…”

Section: Clinical Use Of Alpha Lipoic Acidmentioning

confidence: 87%

Idebenone, green tea, and Coffeeberry® extract: new and innovative antioxidants

Farris

2007

Dermatologic Therapy

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The use of topical antioxidants is gaining favor among dermatologists because of their broad biologic activity. Many are not only antioxidants but also have antiinflammatory and anticarcinogenic activities. Thus for dermatologists these cosmeceuticals have many potential applications. In general, topical antioxidants exert their effects by down-regulating free radical mediated pathways that damage skin. The present study will describe the science behind some of the newest topical antioxidants and outline how they can be used as part of a comprehensive skin care regimen.

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“…Thus, application every other day for the first few weeks may help improve tolerance. Contact dermatitis has also been reported (39). N.V. Perricone M.D.…”

Section: Clinical Use Of Alpha Lipoic Acidmentioning

confidence: 87%

Idebenone, green tea, and Coffeeberry® extract: new and innovative antioxidants

Farris

2007

Dermatologic Therapy

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“…The reduction of TETD in blood plasma has been previously reported (22). The role of mixed disulfide formation in protein haptenation leading to skin sensitization has only been investigated in a few cases with MBT (18), lipoic acid (23), and diallyl disulfide from garlic (24). BSA, which is 80% homologous to human serum albumin (HSA), was used as an analytical tool to examine protein–TETD disulfide formation.…”

Section: Discussionmentioning

confidence: 99%

Zinc diethyldithiocarbamate allergenicity: potential haptenation mechanisms

et al. 2008

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“…Guinea pig studies with MBT and several structural analogues demonstrated that sensitization was most likely a result of protein haptenation via disulfide formation [34]. ACD cases which have also been reported for chemicals like diallyl disulfide [35] and lipoic acid [36] which are thiols further indicate that disulfide formation may be a common mechanism for chemical thiol haptenation. The conclusion that MBT/MBTS haptenates proteins via disulfide formation was supported by enzyme inhibition and protein-binding studies where binding of MBTS to enzymes (reductases) and other protein cysteine residues was through disulfide formation [37].…”

Section: Nonelectrophilic Haptensmentioning

confidence: 99%

Haptenation: Chemical Reactivity and Protein Binding

2011

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Low molecular weight chemical (LMW) allergens are commonly referred to as haptens. Haptens must complex with proteins to be recognized by the immune system. The majority of occupationally related haptens are reactive, electrophilic chemicals, or are metabolized to reactive metabolites that form covalent bonds with nucleophilic centers on proteins. Nonelectrophilic protein binding may occur through disulfide exchange, coordinate covalent binding onto metal ions on metalloproteins or of metal allergens, themselves, to the major histocompatibility complex. Recent chemical reactivity kinetic studies suggest that the rate of protein binding is a major determinant of allergenic potency; however, electrophilic strength does not seem to predict the ability of a hapten to skew the response between Th1 and Th2. Modern proteomic mass spectrometry methods that allow detailed delineation of potential differences in protein binding sites may be valuable in predicting if a chemical will stimulate an immediate or delayed hypersensitivity. Chemical aspects related to both reactivity and protein-specific binding are discussed.

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Contact dermatitis to α‐lipoic acid in an anti‐wrinkle cream

Abstract: In the mid nineties, the major producers and importers withdrew 'acid' CONTACT POINTS

Cited by 16 publications

References 3 publications

Idebenone, green tea, and Coffeeberry® extract: new and innovative antioxidants

Idebenone, green tea, and Coffeeberry® extract: new and innovative antioxidants

Zinc diethyldithiocarbamate allergenicity: potential haptenation mechanisms

Haptenation: Chemical Reactivity and Protein Binding

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