Contact dermatitis with rosacea

Bardazzi, Federico; Manuzzi, P.; G, Riguzzi; Veronesi, S.

doi:10.1111/j.1600-0536.1987.tb01472.x

Cited by 3 publications

(5 citation statements)

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“…PPD was predicted to be a strong/moderate allergen with the help of the TOPS‐MODE QSAR model (13). This is in accordance with clinical experience (1,3–9,30–49), results from the LLNA (22–24,50–57) and predictive testing in both humans (58) and guinea pigs (51). 80 tons of PPD is used annually and it is allowed at up to 6% in hair dyes (12).…”

Section: Discussionsupporting

confidence: 88%

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Ranking of hair dye substances according to predicted sensitization potency: quantitative structure–activity relationships

et al. 2004

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Allergic contact dermatitis following the use of hair dyes is well known. Many chemicals are used in hair dyes and it is unlikely that all cases of hair dye allergy can be diagnosed by means of patch testing with p-phenylenediamine (PPD). The objectives of this study are to identify all hair dye substances registered in Europe and to provide their tonnage data. The sensitization potential of each substance was then estimated by using a quantitative structure-activity relationship (QSAR) model and the substances were ranked according to their predicted potency. A cluster analysis was performed in order to help select a number of chemically diverse hair dye substances that could be used in subsequent clinical work. Various information sources, including the Inventory of Cosmetics Ingredients, new regulations on cosmetics, data on total use and ChemId (the Chemical Search Input website provided by the National Library of Medicine), were used in order to identify the names and structures of the hair dyes. A QSAR model, developed with the help of experimental local lymph node assay data and topological sub-structural molecular descriptors (TOPS-MODE), was used in order to predict the likely sensitization potential. Predictions for sensitization potential were made for the 229 substances that could be identified by means of a chemical structure, the majority of these hair dyes (75%) being predicted to be strong/moderate sensitizers. Only 22% were predicted to be weak sensitizers and 3% were predicted to be extremely weak or non-sensitizing. Eight of the most widely used hair dye substances were predicted to be strong/moderate sensitizers, including PPD - which is the most commonly used hair dye allergy marker in patch testing. A cluster analysis by using TOPS-MODE descriptors as inputs helped us group the hair dye substances according to their chemical similarity. This would facilitate the selection of potential substances for clinical patch testing. A patch-test series with potent, frequently used, substances representing various chemical clusters is suggested. This may prove useful in diagnosing PPD-negative patients with symptoms of hair dye allergy and would provide some clinical validation of the QSAR predictions.

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Section: Discussionsupporting

confidence: 88%

“…patient clinical relevant contact dermatitis (CD) to hair dye(32,33,37,43,46,48). A baby gets CD played with mother's…”

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confidence: 99%

Ranking of hair dye substances according to predicted sensitization potency: quantitative structure–activity relationships

et al. 2004

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“…There is only few data about the ratio of CH in rosacea 2–5 . In this study, the ratio of CH to nickel (7.3%) meets previous data (3.4–15.5%), to that of balsam of Peru (6.1%) is lower than previous data (6.9–10.4%),and to that of fragrance mix I (4.9%) is lower than previous results (5.2–10.3%) 2–5 …”

Section: Frequency Of Ch In 82 Rosacea Patientssupporting

confidence: 70%

“…There are only few data concerning the frequency of contact hypersensitivity (CH) in rosacea, 1–5 although it in fact can play an important role in the therapy or in the daily life of the patients.…”

Section: Frequency Of Ch In 82 Rosacea Patientsmentioning

confidence: 99%

Contact hypersensitivity in rosacea – a study in 82 patients

Pónyai

Kiss

Németh

et al. 2011

Acad Dermatol Venereol

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EditorThere are only few data concerning the frequency of contact hypersensitivity (CH) in rosacea, 1-5 although it in fact can play an important role in the therapy or in the daily life of the patients.The aim of this study was to map the ratio of CH in 82 unselected rosacea patients (68 women, 14 men, over all 18 years, mean age: 54.4) tested in the Department of Dermatology, Venerology and Dermato-oncology of the Semmelweis University between January 2004 and December 2009.The patch tests were performed with Brial GmbH D-Greven series, and the reactions were evaluated (with 48 h occlusion) at 48, 72 and 96 h and on the 7th day. The patients did not take any antihistamine or immunosuppressive agents, and used only indifferent topical treatment 1 week before the tests and at the time of testing. Pregnancy, breast feeding, acute skin symptoms and UV radiation within 6 weeks before testing were drop-out criteria.CH was detected in 29 cases (35.4%). Most common allergens were nickel, balsam of Peru and fragrance mix I (Table 1). Among the relevant allergens, balsam of Peru (5 ⁄ 5), fragrance mix I (4 ⁄ 4), lanalcolum and PPD (3 ⁄ 3) were the most common. Relevant CH can rather be related to cosmetics (46.1%) and washing agents (38.4%). 38.8% of women face creams and make-ups and 20% lotions and gels were in connection with the CH. 27.8% showed CH as a component of therapeutic medical creams. At the time of testing, 80.5% of the patients were over 41 years. In 24 patients, the clinical symptoms had been present for 1-2 years, and in six cases, it was present for over 10 years. Two women had atopic dermatitis. The rosacea symptoms did not show correlation with the occupation of the patients.There is only few data about the ratio of CH in rosacea. [2][3][4][5] In this study, the ratio of CH to nickel (7.3%) meets previous data (3.4-15.5%), to that of balsam of Peru (6.1%) is lower than previous data (6.9-10.4%),and to that of fragrance mix I (4.9%) is lower than previous results (5.2-10.3%). [2][3][4][5] Rosacea patients are very susceptible to adverse reactions caused by external formulations, and so the choice of local treatment and cosmetics is difficult. The presence of CH must be kept in mind. According to our results, relevant CH associate mostly with cosmetics in rosacea patients.

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“…It is well-known that rosacea patients are more susceptible to irritants (2), but little is known about allergy. In rosacea patients, contact dermatitis has been reported from thimerosal and PPD (5) and clindamycin (6). In our series of 29 consecutive patients, a surprisingly high frequency of allergic reactions was observed, 12 (4I%) showing 1 or more reactions to standardized allergens or their own products.…”

Section: Discussionmentioning

confidence: 51%

Rôle of allergic contact dermatitis in rosacea

Cokazza¹,

Malfa²,

Lkmbardi³

et al. 1997

Contact Dermatitis

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Contact Dermatitis 1997: 37: 40 powders at room temperature. He noted urticaria within hours of exposure to them, which evolved into eczema after 1-2 days. Working in a fume cupboard, and wearing gloves and a laboratory coat did not prevent the skin lesions. After several months, he also started to develop mild respiratory symptoms at work. Withdrawal from laboratory work led to complete resolution of the skin lesions. He had no past history of skin disease or atopy, and no other laboratory staff were similarly affected.Patch testing to the European standard series showed allergic reactions to paraphenylene-diamine (D2 ++, D4 +)and caine mix (D2 +, D4 +),and a series of facial allergens were negative. Patch testing with the organic chemicals showed the following results:The purity of both chemicals was confirmed to be greater than 99%. Patch testing was negative in 20 control patients. CommentThe risk of contact allergy from novel or uncommon organic substances is unknown, and we have been unable to find any previous reports of allergic contact dermatitis from 1-( 4-(2-chloroethyl)phenyl)-2-chloroethanol. Our patient had additional symptoms suggestive of immediate-type hypersensitivity, although he was not prick tested. The widespread nature of his eruption could have been due to airborne spread of the fine powder. The rei-SHORT COMMUNICATIONS 4-(2-chloroethyl )phen) lchloromethyl ketone H4·(2·chloroethyl )phenyl )·2-chloroethanol Fig. I.evance of his allergic reactions to caine mix and paraphenylenediamine was undetermined. Recent advances have taken place in understanding how low molecular weight molecules react with skin proteins to form complete allergens, and the reactive chemical groups of common contact allergens have been identified (2). Computer-based expert systems are being developed in an attempt to predict the sensitization hazard of new compounds, based on the presence of structural alerts for chemical reactions and factors that modulate them. Analysis with the expert system DEREK (3) showed that both chloroalkyl groups m 1-( 4-(2-chloroethyl)phenyl)-2-chloroethanol were structural alerts for skin sensitization. ReferencesI. Truxa R. Suchoparek M. Synthesis and characterization of oxirane and oxetane derivatives of styrene. Makromol Patients and MethodsOver a period of 38 months, 29 consecutive patients (4 male and 25 female), aged 18-75 years (mean age 53 years), with rosacea of the face (1, 2) were enrolled in a study. 15 patients had flushing, erythema and telangiectasia, 12 papulopustular rosacea, and 2 males rhinophyma. All patients described intolerance to cosmetics and/ or topical medicaments, exhibited by worsening of burning sensation and of erythema, scaling and papulopustular lesions. Each patient was patch tested with the GIRDCA standard series, preservatives series, emulsifiers series, perfumes series and their own cosmetics and medicaments. Patch tests were read after 2 and 3 days in accordance with GIRDCA recommendations.

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Contact dermatitis with rosacea

Cited by 3 publications

References 0 publications

Ranking of hair dye substances according to predicted sensitization potency: quantitative structure–activity relationships

Ranking of hair dye substances according to predicted sensitization potency: quantitative structure–activity relationships

Contact hypersensitivity in rosacea – a study in 82 patients

Rôle of allergic contact dermatitis in rosacea

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