Contact hypersensitivity to disodium hexachloroplatinate in mice

Schuppe, Hans‐Christian; Kulig, Johanna; Lerchenmüller, Christian; Becker, Detlef; Gleichmann, Ernst; Kind, Peter

doi:10.1016/s0378-4274(97)00085-4

Cited by 13 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is epidemiological evidence that the sensitizing potential of Pt compounds is restricted to halogenated compounds (Linnet and Hughes, 1999). Contact hypersensitivity was also observed on mice by the administration of hexachloroplatinate (Schuppe et al, 1997).…”

Section: Health Effects Of Pgmsmentioning

confidence: 99%

Platinum group elements in the environment and their health risk

Ravindra

Bencs

Grieken

2004

Science of The Total Environment

590

292

View full text Add to dashboard Cite

Accumulation of platinum group elements (PGEs) in the environment has been increased over the time. Catalytic converters of modern vehicles are considered to be the main sources of PGE pollution, since the correlation is between the Pt:Rh ratios in various environmental compartments and in converter units. The present literature survey shows that the concentration of these metals has increased significantly in the last decades in diverse environmental matrices; like airborne particulate matter, soil, roadside dust and vegetation, river, coastal and oceanic environment. Generally, PGEs are referred to behave in an inert manner and to be immobile. However, there is an evidence of spread and bioaccumulation of these elements in the environment. Platinum content of road dusts can be soluble, consequently, it enters the waters, sediments, soil and finally, the food chain. The effect of chronic occupational exposure to Pt compounds is well-documented, and certain Pt species are known to exhibit allergenic potential. However, the toxicity of biologically available anthropogenic Pt is not clear. Hence, there is a need to study the effect on human health of long-term chronic exposure to low levels of Pt compounds.

show abstract

Section: Health Effects Of Pgmsmentioning

confidence: 99%

Platinum group elements in the environment and their health risk

Ravindra

Bencs

Grieken

2004

Science of The Total Environment

590

292

View full text Add to dashboard Cite

show abstract

“…Inorganic platinum compounds, known occupational respiratory sensitizers, have also been shown to induce contact hypersensitivity responses in the murine Local Lymph Node Assay [4,8]. As the mechanisms underlying the responses are still elusive, this study was undertaken to gain more details on potential mechanisms of platinum sensitization.…”

Section: Discussionmentioning

confidence: 99%

“…The symptoms include skin changes (urticaria, contact dermatitis) and respiratory disorders ranging from sneezing, shortness of breath, and cyanosis to severe asthma [2][3][4][5][6]. The sensitizing properties of different platinum salts (e.g., disodium or ammonium hexachloroplatinate) were also proved in mice by means of the Popliteal Lymph Node Assay [3,7] and the Local Lymph Node Assay [8].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-1β and surface marker expression changes induced by tetrachloroplatinate in human monocyte-derived dendritic cells

Arkusz

Gradecka-Meesters

Stępnik

2010

Immunopharmacology and Immunotoxicology

View full text Add to dashboard Cite

MoDCs populations generated from three healthy volunteers displayed the phenotype responsive to NiSO4 and non-responsive to sodium dodecyl sulfate (SDS). Clear up-regulation of IL-1beta mRNA as well as CD54, CD86 and HLA-DR expression in response to NiSO4 (250 microM) was detected after 48 hrs of exposure. No up-regulation of evaluated surface antigens was observed following the treatment with SDS (150 microM). TCPP (150 microM) similarly to NiSO4 induced up-regulation of IL-1beta mRNA, CD54, CD86, but not HLA-DR expression. The response to TCPP showed less inter-individual variability, however it was weaker in comparison to the response to NiSO4. The results suggest that platinum salts can induce in MoDCs phenotypical changes characteristic for skin sensitizers.

show abstract

“…A sensitization level of 0.1 μg m −3 in air for these soluble platinum compounds was reported (Rosner and Merget 2000). The allergic response to Pt increases with increasing number of chlorine atoms, the most potent compounds being hexachloroplatinic (IV) acid and its ammonium and potassium salts, and potassium and sodium tetrachloroplatinite (II) (Schuppe et al 1997). Following the precautionary principle, government agencies in Europe (The Health Council of the Netherlands Expert Committee on Occupational Standards-DECOS) (Joint Statement of the International Platinum Group Metals Association (IPA) and the European Precious Metals Federation (EPMF) 2008) and the United States (Environmental Protection Agency-EPA) are now asserting that the regulation of chloroplatinate sensitization in the workplace, and beyond, should be far more strict, and are proposing new occupational exposure limits (OEL) for chloroplatinates that are several orders of magnitude below current limits (Bullock 2010).…”

Section: Introductionmentioning

confidence: 99%

Speciation Analysis of Chloroplatinates

Vitkova

Chu

Koellensperger

2014

Environmental Science and Engineering

View full text Add to dashboard Cite

Metallic form of platinum is considered to be inert for biological reactions, but in contrast some Pt salts like hexachloroplatinate and tetrachloroplatinate, present at processes in platinum industry and at production of cytostatic platinum compounds, are among the most potent allergens and sensitizers. To assess their potential health risk, development of selective and sensitive analytical methods is inevitable. These compounds can be also found in various environmental compartments where they are released from car catalysts. However, the levels are often orders of magnitude lower which requires effective pretreatment prior to their analysis. In the present work, the most frequently methods used for the preconcentration as well as for speciation analysis of the chlorinated platinum compounds, either in occupational environment or in various natural matrices, will be presented and discussed. Abbreviations CECapillary electrophoresis CE-ICP-MS Capillary electrophoresis-inductively coupled plasma mass spectrometry HPLC High performance liquid chromatography ICP-MS Inductively coupled plasma mass spectrometry LC Liquid chromatography LC-ICP-MS Liquid chromatography-inductively coupled plasma mass spectrometry OEL Occupational exposure limit PGMs Platinum group metals

show abstract

Contact hypersensitivity to disodium hexachloroplatinate in mice

Cited by 13 publications

References 21 publications

Platinum group elements in the environment and their health risk

Platinum group elements in the environment and their health risk

Interleukin-1β and surface marker expression changes induced by tetrachloroplatinate in human monocyte-derived dendritic cells

Speciation Analysis of Chloroplatinates

Contact Info

Product

Resources

About