Contact inhibition of migrating lens epithelial cells at the capsular bend created by a sharp-edged intraocular lens after cataract surgery

Nishi, Okihiro; Yamamoto, Naoki; Nishi, Kayo; Nishi, Yutaro

doi:10.1016/j.jcrs.2007.02.022

Cited by 108 publications

(118 citation statements)

References 23 publications

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“…Ключевыми технологическими моментами в реше-нии проблемы вторичной катаракты являются внутри-капсульная фиксация ИОЛ с формированием кругового капсулярного барьера вокруг ее оптической части, адге-зия ЗКХ к линзе, что предполагает использование ИОЛ с соответствующими свойствами [1,2]. Имеет значение темп трансформации капсульного мешка хрусталика.…”

Section: Discussionunclassified

“…Современные представления о предотвращении вторичной катаракты базируются на теории 'no spaceno cells' , которая предполагает определенный стандарт взаимоотношений между капсульным мешком хруста-лика (КМХ) и интраокулярной линзой (ИОЛ), фор-мируемый в процессе послеоперационной трансфор-мации капсульного мешка и его адаптации к новому содержимому [1,2].…”

Section: актуальностьunclassified

“…В последу-ющие дни наблюдали сближение задней капсулы и ИОЛ с вытеснением жидкости из-под линзы. К 3-5-й неделе обычно формируется механический барьер в виде кап-сульного перегиба вокруг края оптики ИОЛ, и при непол-ном прилегании задней капсулы происходит замыкание остаточного объема жидкости в пространстве ЗКХ-ИОЛ с последующей частичной или полной резорбцией [2,6].…”

Section: ;15(2s):134-139unclassified

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Anatomical and Topographical Relations between the Posterior Lens Capsule and the Intraocular Lens in Pseudoexfoliation Syndrome

Егорова¹

2018

Ophthalmology in Russia

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Purpose— to study the relations between the posterior capsule (PC) and intraocular lens (IOL) after cataract surgery in pseudoexfoliation syndrome (PEX).Patients and methods. We examined 46 eyes of 37 patients with PEX who underwent a standard and uncomplicated phacoemulsification. The age of patients was 60–94 years. Postoperative period ranged from 1 day to 10 years. An optical coherence tomography (OCT) (RTVue XR Avanti, “Optovue”) was used to image the IOL-PC space in early and late postoperative period.Results. In the first days full contact PC-IOL was not observed in any case. The maximum of space PC-IOL was noted on the first day postoperatively. Posterior capsule had a wavy or folded profile on the scans. In the next two weeks we observed a decrease of the distances between posterior capsule and IOL. After 1 month we noted the formation of capsular bend around optic edge, the full adhesion of posterior capsule to IOL was not detected. In the late postoperative period the fibroplastic and proliferative capsular changes with secondary discontact PC-IOL was noted. Primary inadhesion of a posterior capsule to IOL was recorded in half of the cases.и. High resolution OCT was suitable for quantitative analysis of IOL-PC space. Involution changes in structures of anterior segment in the eyes with PEX had a role in closure of the IOL-PC space. Complete adhesion of posterior capsule to IOL was not observed in the majority of eyes with PEX.

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Section: Discussionunclassified

Section: актуальностьunclassified

Section: ;15(2s):134-139unclassified

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Anatomical and Topographical Relations between the Posterior Lens Capsule and the Intraocular Lens in Pseudoexfoliation Syndrome

Егорова¹

2018

Ophthalmology in Russia

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“…Although this in vitro model cannot replicate the bending of the capsular bag that occurs in vivo, correctly sizing the device will result in a tight capsular bend in the peripheral bag at the square edge. 12 This stretching of the posterior capsule should eliminate space between the capsule and the PM and in turn present both the square edge 12 and the Sharklet-patterned PM as mechanical barriers to LEC migration. To validate these results, PMs will be tested in an established rabbit model for PCO.…”

Section: Discussionmentioning

confidence: 99%

“…9 Additionally, IOLs, designed with sharp corners at the optic edge, form a physical barrier to cell migration, and reduce but do not eliminate PCO. [10][11][12][13] Although incidence of PCO has decreased since the introduction of sharp-edge IOLs in clinical practice, clinical studies have shown that LECs migrated across the sharp edge of the IOL optic in 58% of cases, preferentially at the optic-haptic junction in both one-and three-piece IOL designs. 10,14 Recently, a disc-shaped haptic design has emerged as an innovative alternative to these traditional IOL designs.…”

Section: Introductionmentioning

confidence: 99%

Micropatterned Protective Membranes Inhibit Lens Epithelial Cell Migration in Posterior Capsule Opacification Model

Magin¹,

May²,

Drinker³

et al. 2015

Trans. Vis. Sci. Tech.

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Citation: Magin CM, May RM, Drinker MC, Cuevas KH, Brennan AB, Reddy ST. Micropatterned protective membranes inhibit lens epithelial cell migration in posterior capsule opacification model. Tran Vis Sci Tech. 2014;4(2):9, http://tvstjournal. org/doi/full/10. 1167/tvst.4.2.9, doi: 10.1167/tvst.4.2.9 Purpose: To evaluate the ability of Sharklet (SK) micropatterns to inhibit lens epithelial cell (LEC) migration. Sharklet Technologies, Inc. (STI) and InSight Innovations, LLC have proposed to develop a Sharklet-patterned protective membrane (PM) to be implanted in combination with a posterior chamber intraocular lens (IOL) to inhibit cellular migration across the posterior capsule, and thereby reduce rates of posterior capsular opacification (PCO).Methods: A variety of STI micropatterns were evaluated versus smooth (SM) controls in a modified scratch wound assay for the ability to reduce or inhibit LEC migration. The best performing topography was selected, translated to a radial design, and applied to PM prototypes. The PM prototypes were tested in an in vitro PCO model for reduction of cell migration behind an IOL versus unpatterned prototypes and IOLs with no PM. In both assays, cell migration was analyzed with fluorescent microscopy.Results: All SK micropatterns significantly reduced LEC migration compared with SM controls. Micropatterns that protruded from the surface reduced migration more than recessed features. The best performing micropattern reduced LEC coverage by 80%, P ¼ 0.0001 (ANOVA, Tukey Test). Micropatterned PMs reduced LEC migration in a PCO model by 50%, P ¼ 0.0005 (ANOVA, Tukey Test) compared with both IOLs with no PM and IOLs with SM PMs.Conclusions: Collectively, in vitro results indicate the implantation of micropatterned PMs in combination with posterior chamber IOLs could significantly reduce rates of clinically relevant PCO. This innovative technology is a globally accessible solution to high PCO rates.Translational Relevance: A novel IOL incorporating the SK micropattern in a membrane design surrounding the optic may help increase the success of cataract surgery by reducing secondary cataract, or PCO.

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Posterior Capsular Opacification

Awasthi¹

2009

Arch Ophthalmol

303

139

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osterior capsular opacification (PCO) is the most frequent complication of cataract surgery. Advances in surgical techniques, intraocular lens materials, and designs have reduced the PCO rate, but it is still a significant problem. The only effective treatment for PCO, Nd:YAG laser capsulotomy carries vision-related complications and risks and puts a significant financial burden on the health care system. This review contains current knowledge about the mechanisms of PCO development. Posterior capsular opacification is caused mainly by remnant lens epithelial cell proliferation and migration, epithelial-mesenchymal transition, collagen deposition, and lens fiber generation. All of these processes are influenced by cytokines, growth factors, and extracellular matrix proteins. We also describe advances and improvements in surgical techniques, intraocular lens materials, and the designs and use of therapeutic agents leading to safe, effective, and less expensive strategies to eradicate PCO.

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Contact inhibition of migrating lens epithelial cells at the capsular bend created by a sharp-edged intraocular lens after cataract surgery

Cited by 108 publications

References 23 publications

Anatomical and Topographical Relations between the Posterior Lens Capsule and the Intraocular Lens in Pseudoexfoliation Syndrome

Anatomical and Topographical Relations between the Posterior Lens Capsule and the Intraocular Lens in Pseudoexfoliation Syndrome

Micropatterned Protective Membranes Inhibit Lens Epithelial Cell Migration in Posterior Capsule Opacification Model

Posterior Capsular Opacification

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