Contact-Mediated Inhibition Between Oligodendrocyte Progenitor Cells and Motor Exit Point Glia Establishes the Spinal Cord Transition Zone

Smith, Cody J.; Morris, Angela; Welsh, Taylor G.; Kucenas, Sarah

doi:10.1371/journal.pbio.1001961

Cited by 59 publications

(183 citation statements)

References 46 publications

Supporting

Mentioning

179

Contrasting

Order By: Relevance

“…CNSderived motor exit point (MEP) glia and neural crest-derived Schwann cells are responsible for myelinating spinal motor axons (Emery, 2010;Jessen & Mirsky, 2005;Smith et al, 2014). The endoneurium surrounds myelinated axons and the perineurium bundles myelinated and non-myelinated axons to form a nerve fascicle.…”

Section: Development and Organization Of Spinal Motor Nervesmentioning

confidence: 99%

“…MEP glia, also derived from pMN precursors in the spinal cord, exit into the periphery via the same MEP transition zones that axons project through and associate with and myelinate the motor root (Smith et al, 2014). Neural crest-derived Schwann cells also insulating, myelin sheath around individual large caliber axons (Jessen & Mirsky, 2005).…”

Section: Development and Organization Of Spinal Motor Nervesmentioning

confidence: 99%

“…Perineurial glia differentiate to form the mature perineurium, a component of the blood-nerve barrier, and provide protection for the motor axons, acting as both a mechanical and diffusion barrier (Akert et al, 1976;Bourne, 1968;Clark et al, 2014;Jessen & Mirsky, 2005;Kristensson & Olsson, 1971;Kucenas et al, 2008b;Rowitch, 2004;Smith et al, 2014).…”

Section: Development and Organization Of Spinal Motor Nervesmentioning

confidence: 99%

“…Intriguingly, certain peripheral neuropathies result in a phenotype where oligodendrocyte progenitor cells (OPCs), the resident myelinating glial cell of the CNS, ectopically exit the spinal cord, associate with and myelinate peripheral axons (Coulpier et al, 2010;Kucenas et al, 2009;Kucenas et al, 2008b;Smith et al, 2014;Weinberg et al, 1975).…”

Section: Development and Organization Of Spinal Motor Nervesmentioning

confidence: 99%

“…However, a limitation to the study by Lyons et al (2005) Smith et al (2014) in a paper characterizing the novel CNS-derived peripheral myelinating glial cell population called MEP glia (Smith et al, 2014). Characterizing the spinal motor axon myelin defects in erbb3b -/-provided me with a unique and powerful model for assaying perineurial glia plasticity in response to ectopic OPCs during motor nerve assembly, maintenance and injury responses, described in this dissertation.…”

Section: Nrg1mentioning

confidence: 99%

See 4 more Smart Citations

Glial Cell Plasticity During Development and Myelinopathies

Morris¹

View full text Add to dashboard Cite

Forming a functional vertebrate nervous system requires intricate interactions amongst various cell populations, including neurons and glia. Diverse populations of glial cells, such as myelinating glia, i.e., oligodendrocytes of the central nervous system (CNS) and Schwann cells and motor exit point (MEP) glia of the peripheral nervous system (PNS), and perineurial glia, which form the blood-nerve barrier, comprise the nervous system. ii

show abstract

Section: Development and Organization Of Spinal Motor Nervesmentioning

confidence: 99%

Section: Development and Organization Of Spinal Motor Nervesmentioning

confidence: 99%

Section: Development and Organization Of Spinal Motor Nervesmentioning

confidence: 99%

Section: Development and Organization Of Spinal Motor Nervesmentioning

confidence: 99%

Section: Nrg1mentioning

confidence: 99%

See 3 more Smart Citations

Glial Cell Plasticity During Development and Myelinopathies

Morris¹

View full text Add to dashboard Cite

show abstract

Glia Signalling during Neurological Damage and Disease

Heckle

Arena

et al. 2017

Encyclopedia of Life Sciences

View full text Add to dashboard Cite

While glia were once thought to be nothing more than glue‐like cells that hold the nervous system together, there is growing evidence that signals to and from glia are indispensable for development, cell‐to‐cell communication and maintenance of efficient nervous system function. Several studies show that glia often receive conflicting signals during disease progression and can play dual roles as both antagonists and neuroprotectors in distinct settings. Key Concepts Glia play neuroprotective and neurodegenerative role during the initiation and progression stage of neurodegenerative diseases. Astrocytes mediate calcium‐related neurotoxicity in Alzheimer's disease. Microglia regulate neurodegeneration in Parkinson's disease through NO‐related apoptotic pathway. Oligodendrocytes and Schwann cells regulate myelin wasting diseases in central and peripheral nervous system through Wnt and ErbB2/ErbB3 signalling pathways. Glial cells form a scar following spinal cord injury that affects regenerative abilities.

show abstract

Characterizing the diverse cells that associate with the developing commissures of the zebrafish forebrain

Schnabl

Litz

Schneider

et al. 2021

Developmental Neurobiology

View full text Add to dashboard Cite

Development of the central nervous system (CNS) is a complex process that requires the coordinated generation of the correct number, position, and differentiation of neuronal and glial lineages. Vertebrate brain development involves the creation of a diverse array of cell types, the formation of complex neural circuits, and cell migration with tissue level morphogenesis (Kuzmicz-Kowalska & Kicheva, 2020;Lindsey et al., 2018;Namba & Huttner, 2017). The zebrafish, Danio rerio, enables direct and transparent access to the early embryo and possesses growing stockpiles of genetic tools to

show abstract

Contact-Mediated Inhibition Between Oligodendrocyte Progenitor Cells and Motor Exit Point Glia Establishes the Spinal Cord Transition Zone

Abstract: In vivo experiments in zebrafish determine that CNS-derived glial cells contribute to the myelinating population of cells in the PNS and ensure that CNS and PNS glia remain segregated.

Cited by 59 publications

References 46 publications

Glial Cell Plasticity During Development and Myelinopathies

Glial Cell Plasticity During Development and Myelinopathies

Glia Signalling during Neurological Damage and Disease

Characterizing the diverse cells that associate with the developing commissures of the zebrafish forebrain

Contact Info

Product

Resources

About