Contact urticaria and severe anaphylaxis from rifamycin SV

Mancuso, Giuseppe; Masarà, N

doi:10.1111/j.1600-0536.1992.tb05231.x

Cited by 27 publications

(4 citation statements)

References 9 publications

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“…1) whose use varies from tuberculosis therapy to local application to infected wounds. Reactions to these drugs are poorly documented, but systemic reactions to rifamycin SV have been reported [19,20]. The structural similarity of this group of drugs suggests that cross-reactions to other members of the family are highly likely.…”

Section: Non-␤-lactam Antibioticsmentioning

confidence: 99%

Structural determinants of antibiotic allergy

Baldo

Zhao

Pham

2001

Curr Allergy Asthma Rep

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Section: Non-␤-lactam Antibioticsmentioning

confidence: 99%

Structural determinants of antibiotic allergy

Baldo

Zhao

Pham

2001

Curr Allergy Asthma Rep

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“…Despite this widespread use, anaphylaxis from rifamycin SV is not well recognized. [6][7][8][9] Nevertheless, in these case reports it is clearly stressed that potentially life-threatening perioperative anaphylaxis does not per se need parenteral administration of the drug but might result from topical application.…”

Section: Case Reportmentioning

confidence: 99%

Perioperative anaphylaxis from locally applied rifamycin SV and latex

Ebo

Verheecke

Bridts

et al. 2006

British Journal of Anaesthesia

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A patient developed severe anaphylaxis during irrigation of a wound with rifamycin SV. The temporal relationship between application of rifamycin SV, the positive skin test and basophil activation test for rifamycin SV strongly supported diagnosis of anaphylaxis from the locally applied antibiotic. However, after operation the patient had two anaphylactic reactions with pruritus, urticaria and angio-oedema after routine care by a nurse, and these were probably caused by natural rubber latex. This case report has several messages. First, it is not widely appreciated that topically applied drugs and related compounds can elicit life-threatening anaphylaxis. Second, it illustrates patients can present with more than one allergy. Finally, it provides an opportunity to summarize the applications of flow cytometry-assisted quantification of in vitro activated basophils in diagnosing the cause of anaphylaxis during anaesthesia.

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“…We report an immediate adverse reaction probably triggered by the systemic absorption of topically administered rifamycin in a patient with hypersensitivity to ciprofloxacin. Allergic reaction to quinolones and rifamycin are uncommon, but several reports have described anaphylactic reaction 1,2 contact urticaria 3,4 or delayed contact dermatitis 5 after topical application of rifamycin. Adverse reaction to either ciprofloxacin or rifampicin (a semisynthetic derivative of rifamycin used in tuberculosis therapy, involved in several cases of allergic reaction) 6,7 was previously described in five HIV‐infected patients 8 .…”

Section: Skin Prick Testmentioning

confidence: 99%