Contact zones between chromosomal races of Mus musculus domesticus. 3. Molecular and chromosomal evidence of restricted gene flow between the CD race (2n = 22) and the ACR race (2n = 24)

Abstract

Contact zones between chromosomal races of Mus musculus domesticus. 3. Molecular and chromosomal evidence of restricted gene flow between the CD race (2n = 22) and the ACR race (2n = 24) R Castiglia, F Annesi and E Capanna Dipartimento di Biologia Animale e dell' Uomo, Università di Roma "La Sapienza"-Via A. Borelli 50, 00161 Roma, ItalyThe contact zone between the Ancarano (ACR; 2n = 24) and Cittaducale (CD; 2n = 22) races of Mus musculus domesticus was studied. We used chromosomes and mitochondrial DNA (mtDNA) sequences of the control region as genetic markers to detect introgression between races. In total, 76 mice were trapped at 17 localities. Cytogenetic analysis was performed on 73 mice. A segment of the control region (468 bp) was sequenced in 41 specimens. The two races are distributed parapatrically and the contact zone was identified inside a village (Pizzoli). No mixed population was found in the study area. The contact zone does not correspond to any geographical or ecological barrier but is located

Possible involvement of whole-arm reciprocal translocations (WARTs) in the evolution of a Mus musculus domesticus Robertsonian system from Greece

“…Instead, data have emerged, supporting that whole-arm reciprocal translocations (WARTs) may have played a significant role in the evolution of the Rb complexity for the house mouse (Britton-Davidian et al 2005;Capanna and Redi 1995;Castiglia and Capanna 1999a;Castiglia et al 2002;Catalan et al 2000;Hauffe and Piálek 1997;Solano et al 2007;Winking 1986). Each WART is preceded by the formation of chromosomal breaks in the pericentromeric region of the involved chromosomes, the position of which could be the same with what has been described for the 'simple' Rb fusions (Garagna et al 1995;Garagna et al 2001).…”

Nondisjunction rates of mouse specific chromosomes involved in heterozygous Rb rearrangements measured by chromosome painting of spermatocytes II. I. The effects of the number of trivalents

“…If these stable karyotypic races are differentiated by the fixation of multiple, different Rb translocations, they show low levels of gene flow (e.g. Castiglia et al, 2002). On the other hand, the genetic similarity observed between races diverging by only one or a few Rb translocations suggests the persistence of gene flow or a recent divergence in these cases (Britton-Davidian et al, 1989).…”

Linkage-Dependent Gene Flow in a House Mouse Chromosomal Hybrid Zone

“…Gene flow between chromosomal races of house mice has been analyzed using chromosomes, allozymes, and mitochondrial DNA (mtDNA) haplotypes (Saïd et al 1999;Castiglia et al 2002;Hauffe et al 2002), but there have been no studies of gene flow relating to localized regions of the nuclear genome. The goal of the present study was to use mapped microsatellite loci to compare levels of gene flow in centromeric regions of Robertsonian fusions defining the POS and UV races with levels of gene flow in noncentromeric regions of the same chromosomes and at the centromeres of different chromosomes.…”