Contemporary applications of thermogelling PEO-PPO-PEO triblock copolymers

Mfoafo, Kwadwo; Kwon, Young Min; Omidi, Yadollah; Omidian, Hossein

doi:10.1016/j.jddst.2022.103182

Cited by 21 publications

(22 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Significantly different from NM group, P < 0.05, (Supplementary Table 2) hydrophobic to adsorb to the very hydrophobic particle surface. (Mfoafo et al 2022).…”

Section: Partmentioning

confidence: 99%

Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance

et al. 2023

View full text Add to dashboard Cite

Diosmin is a flavonoid with promising anti-inflammatory and antioxidant properties. However, it has difficult physicochemical characteristics since its solubility demands a pH level of 12, which has an impact on the drug’s bioavailability. The aim of this work is the development and characterization of diosmin nanocrystals using anti-solvent precipitation technique to be used for topical treatment of psoriasis. Results revealed that diosmin nanocrystals stabilized with hydroxypropyl methylcellulose (HPMC E15) in ratio (diosmin:polymer; 1:1) reached the desired particle size (276.9 ± 16.49 nm); provided promising colloidal properties and possessed high drug release profile. Additionally, in-vivo assessment was carried out to evaluate and compare the activities of diosmin nanocrystal gel using three different doses and diosmin powder gel in alleviating imiquimod-induced psoriasis in rats and investigating their possible anti-inflammatory mechanisms. Herein, 125 mg of 5% imiquimod cream (IMQ) was applied topically for 5 consecutive days on the shaved backs of rats to induce psoriasis. Diosmin nanocrystal gel especially in the highest dose used offered the best anti-inflammatory effect. This was confirmed by causing the most statistically significant reduction in the psoriasis area severity index (PASI) score and the serum inflammatory cytokines levels. Furthermore, it was capable of maintaining the balance between T helper (Th17) and T regulatory (Treg) cells. Moreover, it tackled TLR7/8/NF-κB, miRNA-31, AKT/mTOR/P70S6K and elevated the TNFAIP3/A20 (a negative regulator of NF-κB) expression in psoriatic skin tissues. This highlights the role of diosmin nanocrystal gel in tackling imiquimod-induced psoriasis in rats, and thus it could be a novel promising therapy for psoriasis. Graphical abstract

show abstract

“…Significantly different from NM group, P < 0.05, (Supplementary Table 2) hydrophobic to adsorb to the very hydrophobic particle surface. (Mfoafo et al 2022).…”

Section: Partmentioning

confidence: 99%

Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Poloxamer 407 (P407) is one of the most commonly used thermosensitive materials for preparing thermosensitive hydrogels [ 18 , 19 ]. It is a nonionic PEO-PPO-PEO triblock copolymer consisting of a central hydrophobic chain of polypropylene (PPO) and two identical lateral hydrophilic chains of polyethylene oxide (PEO) [ 20 ]. Its inverse thermogelling property makes it a flowable solution at room temperature (<25 °C), which can be delivered into the abdominal injury site by injection.…”

Section: Introductionmentioning

confidence: 99%

“…The three-dimensional mesh structure of P407 can distribute the hydrophilic drug in the free solvent outside the micelles, while the hydrophobic drug is encapsulated inside the micelles. As the gel degrades or dissolves in vivo, the drug is slowly released, extending the retention time in vivo [ 20 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

The Controlled Release and Prevention of Abdominal Adhesion of Tannic Acid and Mitomycin C-Loaded Thermosensitive Gel

Liu

Wang

et al. 2023

Polymers

View full text Add to dashboard Cite

Postoperative abdominal adhesion is one of the most common complications after abdominal surgery. A single drug or physical barrier treatment does not achieve the ideal anti-adhesion effect. We developed a thermosensitive hydrogel (PPH hydrogel) consisting of poloxamer 407 (P407), poloxamer (P188), and hydroxypropyl methylcellulose (HPMC) co-blended. An injectable thermosensitive TA/MMC-PPH hydrogel was obtained by loading tannic acid (TA) with an anti-inflammatory effect and mitomycin C (MMC), which inhibits fibroblast migration or proliferation. The optimal prescriptions of PPH hydrogels with a suitable gelling time (63 s) at 37 °C was 20% (w/v) P407, 18% (w/v) P188, and 0.5% (w/v) HPMC. The scanning electron microscopy (SEM) revealed that the PPH hydrogel had a three-dimensional mesh structure, which was favorable for drug encapsulation. The PPH hydrogel had a suitable gelation temperature of 33 °C, a high gel strength, and complicated viscosity at 37 °C, according to the rheological analysis. In vitro release studies have shown that the PPH hydrogel could delay the release of TA and MMC and conform to the first-order release rate. Anti-adhesion tests performed on rats in vivo revealed that TA/MMC-PPH hydrogel significantly reduced the risk of postoperative adhesion. In conclusion, the TA/MMC-PPH hydrogel prepared in this study showed an excellent performance in both controlled drug release and anti-adhesive effects. It can be used as a protocol to prevent or reduce postoperative abdominal adhesion.

show abstract

“…Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers, known as poloxamers or Pluronics, are thermoresponsive amphiphilic macromolecules used to develop in situ gel systems in aqueous solutions [ 1 , 2 , 3 , 4 , 5 ]. They are widely utilized in various pharmaceutical dosage forms, including oral, parenteral, ocular, topical, vaginal, and rectal, as they are FDA-approved, non-toxic, and non-irritant excipients [ 1 , 6 ]. Pluronic F127 (Poloxamer 407) with an average molecular weight of 12,600 Da and a PEO/PPO weight ratio of 70:30 [ 7 ] is one of the most widely used poloxamers in pharmaceutical preparations.…”

Section: Introductionmentioning

confidence: 99%

Design of Functional Pluronic-Based Precursors for Tailoring Hydrogel Thermoresponsiveness and Cell-Adhesive Properties

Camana

Tavano

et al. 2023

Materials

View full text Add to dashboard Cite

In this study, functional Pluronic F127 precursors were designed and synthesized for the preparation of thermosensitive hydrogels. Using linear Pluronic thioacetate and Pluronic multi-acrylate precursors, F127-based hydrogels were prepared through thioacetate deprotection-mediated Michael-type addition. The properties of these gels were compared to those obtained through free radical crosslinking of F127 diacrylate. Temperature was found to have a clear influence on gel swelling as a result of F127 thermoresponsiveness. The macromolecular architecture and functionality of the precursors were also optimized and characterized in terms of gelation kinetics and drug diffusion. In vitro tests were conducted on fibroblasts and endothelial cells to assess their response to cellular adhesion with Pluronic gels that were functionalized with an RGD peptide or pretreated with serum proteins to promote cell adhesion. This study provides a method for creating tailored hydrogels suitable for various biomedical applications, such as soft-tissue engineering, cell encapsulation, wound healing, and sustained delivery of therapeutic molecules.

show abstract

Contemporary applications of thermogelling PEO-PPO-PEO triblock copolymers

Cited by 21 publications

References 109 publications

Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance

Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance

The Controlled Release and Prevention of Abdominal Adhesion of Tannic Acid and Mitomycin C-Loaded Thermosensitive Gel

Design of Functional Pluronic-Based Precursors for Tailoring Hydrogel Thermoresponsiveness and Cell-Adhesive Properties

Contact Info

Product

Resources

About