Contemporary Prevalence and risk factors of carotid artery stenosis in asymptomatic low-income Chinese individuals: a population-based study

Zhang, Kai; Lin, Qiuxing; Zhang, Tianyu; Guo, Dandan; Cao, Li

doi:10.1080/00325481.2020.1788319

Cited by 9 publications

(12 citation statements)

References 37 publications

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“…This fact can be explained by more intensive hypolipidemic therapy with statins in the atherosclerosis groups. A long history of arterial hypertension (≥18 years) was associated with CAS, which is consistent with the data of other authors [ 10 , 11 , 13 ]. At the same time, we did not detect the significance of smoking among the risk factors, as was noted previously [ 14 ].…”

Section: Discussionsupporting

confidence: 92%

“…While the role of older age as a risk factor for CA is not questioned [ 14 , 32 ], the data on the relationship of CA with gender and body weight in patients with T2D are rather inconsistent. Some authors have identified male gender as a risk factor for CA and CAS in T2D subjects [ 10 , 13 ]; meanwhile, others have observed a higher prevalence of CA in T2D women [ 14 , 32 ]. In previous studies, visceral adiposity was linked to CA in subjects with T2D [ 14 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…The results of previous research linked CA with dyslipidemia [ 11 , 13 ]. In our patients, no connection was found between the levels of lipids and CA.…”

Section: Discussionmentioning

confidence: 99%

“…The role of hyperglycemia as a promoter of atherogenesis is discussed widely [ 36 , 37 ]. In mixed diabetic and non-diabetic populations, glycemic status has been recognized as a risk factor for CA [ 15 ] and CAS [ 13 , 15 , 16 , 38 ]. In our cohort, diabetes duration ≥ 11 and ≥13 years was associated with CA and CAS, respectively, in the ROC analysis; moreover, diabetes duration was an independent risk factor for CAS in the multivariate model.…”

Section: Discussionmentioning

confidence: 99%

“…It has been documented that the risk of CA is higher in diabetic patients than in the general population [ 8 , 9 ]. Accelerated CA in diabetes is usually attributed to the cumulative effect of traditional risk factors, such as age, smoking, hypertension, visceral obesity, dyslipidemia, and chronic kidney disease (CKD), although the contribution of each factor varies between studies [ 10 , 11 , 12 , 13 , 14 ]. Furthermore, the role of hyperglycemia as a promoter of CA has also been postulated [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Carotid Artery Disease in Subjects with Type 2 Diabetes: Risk Factors and Biomarkers

Климонтов

Koroleva

Khapaev

et al. 2021

JCM

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Carotid atherosclerosis (CA) and, especially, carotid artery stenosis (CAS), are associated with a high risk of cardiovascular events in subjects with type 2 diabetes (T2D). In this study, we aimed to identify risk factors and biomarkers of subclinical CA and CAS in T2D individuals. High-resolution ultrasonography of carotid arteries was performed in 389 patients. Ninety-five clinical parameters were evaluated, including diabetic complications and comorbidities; antihyperglycemic, hypolipidemic, and antihypertensive therapy; indices of glycemic control and glucose variability (GV); lipid panels; estimated glomerular filtration rate (eGFR); albuminuria; blood cell count; and coagulation. Additionally, serum levels of calponin-1, relaxin, L-citrulline, and matrix metalloproteinase-2 and -3 (MMP-2, -3) were measured by ELISA. In univariate analysis, older age, male sex, diabetes duration, GV, diabetic retinopathy, chronic kidney disease, coronary artery disease, peripheral artery disease, and MMP-3 were associated with subclinical CA. In addition to these factors, long-term arterial hypertension, high daily insulin doses, eGFR, and L-citrulline were associated with CAS. In multivariate logistic regression, age, male sex, BMI, GV, and eGFR predicted CA independently; male sex, BMI, diabetes duration, eGFR, and L-citrulline were predictors of CAS. These results can be used to develop screening and prevention programs for CA and CAS in T2D subjects.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

“…The results of previous research linked CA with dyslipidemia [ 11 , 13 ]. In our patients, no connection was found between the levels of lipids and CA.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Carotid Artery Disease in Subjects with Type 2 Diabetes: Risk Factors and Biomarkers

Климонтов

Koroleva

Khapaev

et al. 2021

JCM

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National and Provincial-Level Prevalence and Risk Factors of Carotid Atherosclerosis in Chinese Adults

Fu,

Deng,

et al. 2024

JAMA Netw Open

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ImportanceEpidemiologic studies on carotid atherosclerosis (CAS) based on nationwide ultrasonography measurements can contribute to understanding the future risk of cardiovascular diseases and identifying high-risk populations, thereby proposing more targeted prevention and treatment measures.ObjectivesTo estimate the prevalence of CAS within the general population of China and to investigate its distribution among populations with potential risk factors and variation across diverse geographic regions.Design, Setting, and ParticipantsThis multicenter, population-based cross-sectional study used China’s largest health check-up chain database to study 10 733 975 individuals aged 20 years or older from all 31 provinces in China who underwent check-ups from January 1, 2017, to June 30, 2022.Main Outcomes and MeasuresCarotid atherosclerosis was assessed and graded using ultrasonography as increased carotid intima-media thickness (cIMT), carotid plaque (CP), and carotid stenosis (CS). The overall and stratified prevalences were estimated among the general population and various subpopulations based on demographic characteristics, geographic regions, and cardiovascular disease risk factors. Mixed-effects regression models were used to analyze the risk factors for CAS.ResultsAmong 10 733 975 Chinese participants (mean [SD] age, 47.7 [13.4] years; 5 861 566 [54.6%] male), the estimated prevalences were 26.2% (95% CI, 25.0%-27.4%) for increased cIMT, 21.0% (95% CI, 19.8%-22.2%) for CP, and 0.56% (95% CI, 0.36%-0.76%) for CS. The prevalence of all CAS grades was higher among older adults (eg, increased cIMT: aged ≥80 years, 92.7%; 95% CI, 92.2%-93.3%), male participants (29.6%; 95% CI, 28.4%-30.7%), those residing in northern China (31.0%; 95% CI, 29.1%-32.9%), and those who had comorbid conditions, such as hypertension (50.8%; 95% CI, 49.7%-51.9%), diabetes (59.0%; 95% CI, 57.8%-60.1%), dyslipidemia (32.1%; 95% CI, 30.8%-33.3%), and metabolic syndrome (31.0%; 95% CI, 29.1%-32.9%). Most cardiovascular disease risk factors were independent risk factors for all CAS stages (eg, hypertension: 1.60 [95% CI, 1.60-1.61] for increased cIMT, 1.62 [95% CI, 1.62-1.63] for CP, and 1.48 [95% CI, 1.45-1.51] for CS). Moreover, the magnitude of the association between several cardiovascular disease risk factors and increased cIMT and CP differed between the sexes and geographic regions.Conclusions and RelevanceThese findings suggest that nearly one-quarter of Chinese adults have increased cIMT or CP. The burden of this disease is unevenly distributed across geographic regions and subpopulations and may require different levels of local planning, support, and management. Addressing these disparities is crucial for effectively preventing and managing cardiovascular and cerebrovascular diseases in China.

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Prevalence and associated risk factors of carotid plaque and artery stenosis in China: a population-based study

Zeng,

Zhang,

Liu

et al. 2024

Front. Med.

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Contemporary Prevalence and risk factors of carotid artery stenosis in asymptomatic low-income Chinese individuals: a population-based study

Cited by 9 publications

References 37 publications

Carotid Artery Disease in Subjects with Type 2 Diabetes: Risk Factors and Biomarkers

Carotid Artery Disease in Subjects with Type 2 Diabetes: Risk Factors and Biomarkers

National and Provincial-Level Prevalence and Risk Factors of Carotid Atherosclerosis in Chinese Adults

Prevalence and associated risk factors of carotid plaque and artery stenosis in China: a population-based study

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