1972
DOI: 10.1002/cpt1972133323
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Content analysis of speech samples to determine effect of lorazepam on anxiety

Abstract: A study is described illustrating the me, in neuropsychpharmacologic studies, of an objective measure of psychological states, such as anxiety, through the content analysis of 5 minute samples of speech. In this report, the psychoactive drug tested was a new benzodiazepine, lorazepam. It was found to exert significant antianxiety effects (p <0.05) as measured by the content analysis method when administered parenterally at a dosage of 5.0 mg. compared to anxiety changes occurring after no drug or 3.0 mg. of lo… Show more

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Cited by 13 publications
(1 citation statement)
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“…The affect scores of anxiety and hostility are very sensitive to many conditions, for example, the passage of time (see the generalizability studies of Gottschalk and Gleser, 1969, pp. 59-67); phases of the menstrual cycle (Gottschalk et al, 1962;Ivey and Bardwick, 1968;Sflbergeld et al, 1971); increases in serum dopamine beta-hydroxylase (Sflbergeld et al, 1975); different interviewers (Gottschalk and Gteser, 1969;Gottschalk, 1971;Schofer et al, 1978); various psychoactive drugs, such as perphenazine (Gottschalk et aL, 1960), amytal (Ross et al, 1963), chlordiazepoxide (Gleser et al, 1965;Gottschalk and Kaplan, 1972), and lorazepam (Gottschalk et al, 1972a); sex (Gottschalk and Gleser, 1969); and aging (Gottschalk and Gleser, 1969).…”
Section: Discussionmentioning
confidence: 97%
“…The affect scores of anxiety and hostility are very sensitive to many conditions, for example, the passage of time (see the generalizability studies of Gottschalk and Gleser, 1969, pp. 59-67); phases of the menstrual cycle (Gottschalk et al, 1962;Ivey and Bardwick, 1968;Sflbergeld et al, 1971); increases in serum dopamine beta-hydroxylase (Sflbergeld et al, 1975); different interviewers (Gottschalk and Gteser, 1969;Gottschalk, 1971;Schofer et al, 1978); various psychoactive drugs, such as perphenazine (Gottschalk et aL, 1960), amytal (Ross et al, 1963), chlordiazepoxide (Gleser et al, 1965;Gottschalk and Kaplan, 1972), and lorazepam (Gottschalk et al, 1972a); sex (Gottschalk and Gleser, 1969); and aging (Gottschalk and Gleser, 1969).…”
Section: Discussionmentioning
confidence: 97%