Content of Brain Aluminum Is Not Elevated in Alzheimer Disease

Bjertness, Espen; Candy, J.M.; Torvik, Ansgar; Ince, PG; McArthur, F.K.; Taylor, GeoffA; Johansen, Silje; Alexander, James L.; Grønnesby, J K; Bakketeig, Leiv S.; Edwardson, J. A.

doi:10.1097/00002093-199601030-00006

Cited by 84 publications

(31 citation statements)

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“…Aluminum (Al) has been suggested to accelerate or play a causal role in the pathogenesis of AD. The metal is found in the brain of patients with this disorder [10, 39,541. However, other studies have been unable to confirm these findings [5,23,31 ]. [2,32,36,42].…”

Section: Introductionmentioning

confidence: 88%

Aluminum and copper interact in the promotion of oxidative but not inflammatory events: Implications for Alzheimer's disease

Becaria

Bondy

Campbell

2003

JAD

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Abstract. The etiology of Alzheimer's Disease (AD) is multifactorial. It has been suggested that transition metals such as copper (Cu) and iron (Fe) as well as aluminum (Al) may be involved in the pathogenesis of the disorder. While Cu and Fe are redox-active, Al only exists in the trivalent form and is redox-inert. We previously demonstrated that Al exposure causes an increase in inflammatory parameters in human glioblastoma T98G cells. In the present study we further demonstrate that co-exposure with Cu exacerbates the oxidative but not inflammatory effects of Al in this cell line. While Cu-induced reactive oxygen species (ROS) production was greatly enhanced in the presence of Al, TNF-a secretion induced by either metal was not further potentiated by simultaneous exposure to Al and Cu. Furthermore, exposure to both metals reduced the individual Al and Cu-induced activation of the immune-related transcription factor NF-,,,;B. Therefore, while synergistic interaction between the two metals increases oxidative events, this does not lead to potentiation of Al-induced inflammation. Thus the ability of aluminum to promote inflammatory processes does not depend on an increase ROS production induced by interaction with transition metals.

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Section: Introductionmentioning

confidence: 88%

Aluminum and copper interact in the promotion of oxidative but not inflammatory events: Implications for Alzheimer's disease

Becaria

Bondy

Campbell

2003

JAD

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“…The original description of this connection (Perl and Brody, 1980) was disputed due to the problem of obtaining accurate Al analyses and the probability of sample contamination (Bjertness et al, 1996). However, a wide range of more sophisticated analytical procedures including laser microprobe mass analysis (Bouras et al, 1997), instrumental neutron activation (Andrasi et al, 2005), an improved graphite furnace atomic absorption method (Xu et al, 1992) or energy-dispersive X-ray spectroscopy combined with transmission electron microscopy (Yumoto et al, 2009), have all basically confirmed the original findings.…”

Section: Inflammation Is Pronounced In the Aging Brain And This Is Fmentioning

confidence: 96%

Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration

Bondy

2016

NeuroToxicology

208

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“…The extract was concentrated by distilling the solvent and preserved under refrigeration for further studies. The obtained dried extract was further subjected to various chemical tests to detect the presence of different phytoconstituents [9].…”

Section: Extraction Of Plant Materialsmentioning

confidence: 99%

Neuroprotective Effect of Anacardium Occidentale (Cashew Apple Fruit) Against Aluminum Toxicity: An Experimental Study on Cognitive Dysfunction and Biochemical Alterations in Rats

Kalyani

Bhagyasree²

2017

Asian J Pharm Clin Res

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Objective: To study the protective role of fruit extract of Anacardium occidentale (cashew apple) in aluminum-induced cognitive dysfunction and oxidative damage in albino rat, and to explore the neuroprotective effect of A. occidentale represented by behavior and memory tests. Methods:Male Wistar rats (30) were divided into 5 groups of 6 rats each. Group I received normal saline. Group II was administered orally with aluminum chloride (100 mg/kg). Group III received rivastigmine 0.3 mg/kg body orally. Groups IV and V were administered with A. occidentale 200 and 400 mg/kg along with aluminum chloride of 100 mg/kg orally after 1 hr interval. The study was carried out for 42 days (6 weeks). The behavioral assessment was performed using Rota-rod apparatus and Elevated plus maze and Biochemical parameters from brain homogenate such as acetylcholinesterase activity, total protein, lipid peroxidation malondialdehyde, superoxide dismutase (SOD), catalase, and glutathione reductase (GR) were estimated. All the data were analyzed using one-way analysis of variance followed by Tukey's multiple comparison test. Results:The % reduction of acetylcholinesterase, GR observed in A.O (400 mg/kg) dose as compared with that of standard drug was found to be 87.5% and 89%, respectively, whereas % reduction of catalase and SOD observed in A.O (400 mg/kg) dose as compared with that of standard drug was found to be 97% and 99%, respectively. Conclusion:This study demonstrates A. occidentale fruit has a neuroprotective effect against aluminum-induced behavioral changes.

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Content of Brain Aluminum Is Not Elevated in Alzheimer Disease

Cited by 84 publications

References 0 publications

Aluminum and copper interact in the promotion of oxidative but not inflammatory events: Implications for Alzheimer's disease

Aluminum and copper interact in the promotion of oxidative but not inflammatory events: Implications for Alzheimer's disease

Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration

Neuroprotective Effect of Anacardium Occidentale (Cashew Apple Fruit) Against Aluminum Toxicity: An Experimental Study on Cognitive Dysfunction and Biochemical Alterations in Rats

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