Content of delta-sleep-inducing peptide in the brain of rats with different levels of alcohol motivation

Burov, Yu. V.; Yukhananov, R. Yu.; Maiskii, A. I.

doi:10.1007/bf00835633

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1984

1991

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Cited by 5 publications

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“…Ethanol injection leads to an increase in DSIP level in the brain. The animals predisposed to voluntary ethanol consumption have a lower DSIP concentration as compared with nonpredisposed ones (Burov et al, 1982). Ethanol and DSIP relieve the stress reaction, but the mechanisms of their action are opposite, e.g., ethanol increases the level of corticosterone in the blood plasma, whereas DSIP decreases its level under stress conditions .…”

Section: Introductionmentioning

confidence: 98%

Effect of Ethanol and DSIP on the36Cl− flux in synaptosomal vesicles

Yukhananov

Rebrov

Tennilä

et al. 1991

Molecular and Chemical Neuropathology

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Delta-sleep-inducing peptide (DSIP) is an endogenous substance that regulates the response of the organism to stress. It was found that DSIP, like diazepam and ethanol, activates muscimol-stimulated 36Cl- uptake in the rat brain cortex and partially counteracts the stimulatory action of ethanol on this process. The effect of peptide disappears at the lowering of the incubation temperature. We propose that DSIP is a concordant regulator partly mediating its action through the membrane phospholipids.

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Section: Introductionmentioning

confidence: 98%